Denitrogenative Transformations of Pyridotriazoles and Related Compounds: Synthesis of <i>N</i>-Containing Heterocyclic Compounds and Beyond
The high demand for new and efficient routes toward synthesis of nitrogen-containing heterocyclic scaffolds has inspired organic chem-ists to discover several methodologies over recent years, which involves the use of pyri-dotriazoles and related compounds in denitrogenative transformations.
Abstract
The high demand for new and efficient routes toward synthesis of nitrogen-containing heterocyclic scaffolds has inspired organic chemists to discover several methodologies over recent years. This Perspective highlights one standout approach, which involves the use of pyridotriazoles and related compounds in denitrogenative transformations. Readily available pyridotriazoles undergo ring-chain isomerization to produce uniquely reactive α-diazoimines. Such reactivity, enabled by metal catalysts, additives, or visible-light irradiation, can be applied in transannulation, insertion, cyclopropanation, and many other transformations.