The JAK/STAT signaling pathway: from bench to clinic
In this review, the current knowledge about the composition, activation, and regulation of the JAK/STAT pathway is discussed and the role of this signaling pathway and its inhibitors in various diseases is highlighted.
Abstract
<jats:title>Abstract</jats:title><jats:p>The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of various critical mediators of cancer and inflammation. Growing evidence suggests that dysregulation of the JAK/STAT pathway is associated with various cancers and autoimmune diseases. In this review, we discuss the current knowledge about the composition, activation, and regulation of the JAK/STAT pathway. Moreover, we highlight the role of the JAK/STAT pathway and its inhibitors in various diseases.</jats:p>