A happy medium: the synthesis of medicinally important medium-sized rings <i>via</i> ring expansion
202 Citations•2020•
Aimee K. Clarke, William P. Unsworth
This minireview has drawn on recent progress to highlight the key reaction design features that enable successful ‘normal-to-medium’ ring expansion for the synthesis of these medicinally important molecular frameworks.
Abstract
<p>Ring expansion strategies are ideally suited to make synthetically challenging, medium-sized rings with much potential in medicinal chemistry.</p>