The creatine kinase conundrum: a reappraisal of the association of isotretinoin, creatine kinase, and rhabdomyolysis
18 Citations•2019•
Justin W. Marson, Hilary Baldwin
Isotretinoin has been reported to elevate creatine kinase, which may lead to fatal rhabdomyolysis.
Abstract
Evidence supports a tenuous correlation between isotretinoin, elevated creatine kinase, and exercise. Physicians should consider obtaining baseline creatine kinase on elite athletes and counseling patients on risk factors that may elevate creatine kinase. However, the potential for elevated CK is not a contraindication for isotretinoin therapy.