Novel Fecal Biomarkers That Precede Clinical Diagnosis of Ulcerative Colitis
172 Citations•2020•
Heather J. Galipeau, Alberto Caminero, Williams Turpin
Increased fecal proteolytic activity that precedes the clinical diagnosis of UC and associates with gut microbiota changes is identified and may constitute a non-invasive biomarker of inflammation to monitor at-risk populations that can be targeted therapeutically with anti-proteases.
Abstract
We have identified increased fecal proteolytic activity that precedes the clinical diagnosis of UC and associates with gut microbiota changes. This proteolytic signature may constitute a noninvasive biomarker of inflammation to monitor at-risk populations that can be targeted therapeutically with antiproteases.