Microcapsules and Nanoparticles in Medicine and Pharmacy
This work focuses on Microencapsulation of Living Cells and Tissues, and on recent Advances in Artificial Cells with Emphasis on Biotechnological Approaches Based on Micro Encapsulation.
Abstract
Introduction and Overview. PART I: ADVANCES IN PRODUCTION TECHNOLOGY AND CHARACTERIZATION OF MICROCAPSULES, MICROSPHERES, AND NANOPARTICLES. Developments in Phase Separation Methods, Aggregation Control, and Mechanisms of Microencapsulation (Max Donbrow). Formation of Degradable Drug-Loaded Microparticles by In-Liquid Drying Processes (Curt Thies). Fluid-Bed Spray Coating (K. Lehmann). Polyanhydride Microspheres as Drug Delivery Systems (Edith Mathiowitz and Robert Langer). Nanoparticles - Preparation and Applications (J. Kreuter). Recent Advances Using Microencapsulation for Taste Masking of Bitter Drugs (J.A. Bakan, T.C. Powell, R.W. Roark, and P.S. Szotak). PART II: BIOLOGICAL TRANSIT AND INTERACTIONS, RELEASE KINETICS, PHARMACOKINETICS AND BIOAVAILABILITY. Gastrointestinal Transit of Microcapsules (John T. Fell). Interaction of Microcapsules with Blood Components (Tamotsu Kondo). Recent Advances in Microencapsulation of Drugs to Obtain Reduced Gastric Irritation (J.A. Bakan, T.C. Powell, R.W. Roark, and P.S. Szotak). In Vitro Release from Microcapsules and Microspheres (Ivan Jalsenjak). The Relation of Release Profiles from Ensembles to Those of Individual Microcapsules and the Influence of Types of Batch Heterogeneity on Release Kinetics (Max Donbrow). Pharmacokinetic Considerations Related to Bioavailability of Sustained-Release Microencapsulated Drugs for Oral Use - Assessment of Absorption Rates (Shigeru Goto and Takahiro Uchida). PART III: CLINICAL APPLICATIONS, TARGETING, AND LIVING AND ARTIFICIAL ENCAPSULATED CELLS. Clinical Uses of Microcapsules and Microspheres (Kazuhiko Juni and Masahiro Nakano). Chemo-Embolization and Passive Targeting with Degradable Starch Microspheres (Peter Edman and Ingvar Sj holm). Active Targeting of Microcapsules and Microspheres to Specific Regions (Julia J. Wright and Lisbeth Illum). Erythrocytes as Microvesicles (David A. Lewis and H. Oya Alpar). Microencapsulation of Living Cells and Tissues. (Anthony M. Sun , Ivan Vacek, and Isaballa Tai). Recent Advances in Artificial Cells with Emphasis on Biotechnological Approaches Based on Microencapsulation (Thomas Ming Swi Chang).