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Cell death

733 Citations2024
Kim Newton, Andreas Strasser, Nobuhiko Kayagaki

The signaling mechanisms underlying each cell-death pathway are reviewed, how impaired or excessive activation of the distinct cell-death processes can promote disease are discussed, and existing and potential therapies for redressing imbalances in cell death in cancer and other diseases are highlighted.

Abstract

Cell death supports morphogenesis during development and homeostasis after birth by removing damaged or obsolete cells. It also curtails the spread of pathogens by eliminating infected cells. Cell death can be induced by the genetically programmed suicide mechanisms of apoptosis, necroptosis, and pyroptosis, or it can be a consequence of dysregulated metabolism, as in ferroptosis. Here, we review the signaling mechanisms underlying each cell-death pathway, discuss how impaired or excessive activation of the distinct cell-death processes can promote disease, and highlight existing and potential therapies for redressing imbalances in cell death in cancer and other diseases.