Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold
101 Citations•2023•
Siva S. Panda, Adel S. Girgis, Marian N. Aziz
The present article summarizes the recent development of both natural and synthetic spirooxindole-containing compounds prepared from isatin or its derivatives reported in the last five years.
Abstract
<jats:p>Spirooxindoles occupy an important place in heterocyclic chemistry. Many natural spirooxindole-containing compounds have been identified as bio-promising agents. Synthetic analogs have also been synthesized utilizing different pathways. The present article summarizes the recent development of both natural and synthetic spirooxindole-containing compounds prepared from isatin or its derivatives reported in the last five years. The spirooxindoles are categorized based on their mentioned biological properties.</jats:p>