Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns
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Abstract
Nicotinamide adenine dinucleotide (NAD<sup>+</sup>) levels in the body deplete with aging and it is associated with downregulation of energy production in mitochondria, oxidative stress, DNA damage, cognitive impairment and inflammatory conditions. However, NMN, as the precursor of NAD<sup>+</sup>, can slow down this process by elevating NAD<sup>+</sup> levels in the body. A number of <i>in vivo</i> studies have indicated affirmative results of therapeutic effects for various age-induced complications with NMN supplementation. One preclinical and one clinical study have been conducted to investigate the safety concerns of NMN administration while a few more human clinical trials are being conducted. As there is a large influx of NMN based anti-aging products on the market, proper clinical investigations are urgently needed to find out the effectiveness and safety of NMN supplementation.