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Associations of immunological proteins/traits with schizophrenia, major depression and bipolar disorder: A bi-directional two-sample mendelian randomization study
191 Citations•2021•
Benjamin I. Perry, Rachel Upthegrove, Nils Kappelmann
Evidence is reported in support of potential causal associations of several immunological proteins/traits with schizophrenia, and of IL-6 with depression, and from bidirectional MR did not support reverse causality.
Abstract
We report evidence in support of potential causal associations of several immunological proteins/traits with schizophrenia, and of IL-6 with depression. Some of the findings did not survive correction for multiple testing and so replication in larger samples is required. Experimental studies are also required to further examine causality, mechanisms, and treatment potential for these immunological proteins/pathways for schizophrenia and depression.