Top Research Papers on Biology

An Overview of the Biology of Trematodes, B.W. Haseeb and B.P. Thompson Host Recognition by Trematode Miracidia and Cercariae, W.M. Tielens Trem atode Neurobiology, D.G. Maule, and C.J. Shaw Immunobiology of Trem atodes in Vertebrate Hosts.

In this age of modern era, the use of internet must be maximized to get the on-line concepts in biology book, as the world window, as many people suggest.

Simulation tests show that when a strategic and representative selection of species for higher-level categories has been made for multigene sequencing, the addition of this multilocus backbone DNA data for as few as 5–10% of the specimens in the total data set can produce high-quality phylogenies, comparable to those resulting from 100% multigenes sampling.

This Element is an introduction to the metaphysics of biology, a very general account of the nature of the living world that argues throughout for a view of living systems as processes rather than things or, in the technical philosophical sense, substances.

It is found that shortly after the Omicron variant had begun spreading in Canada, the expected daily number of spillovers, infections spread to NL community members from travellers and their close contacts, was higher than any time previously in the pandemic.

Recently, prebiotic dietary fibers and sodium-glucose cotransporter 2 inhibitors have been proposed as promising new therapeutic pathways to treat hypomagnesemia.

An updated overview of the uromodulin's biology and its various roles is presented, and the interaction between uromodulin and sodium-sensitive hypertension is focused on.

The perspective of iron metabolism in the setting of CKD is broadened not just as a contributor to anaemia in CKD patients, but also as an important player with an impact on cell metabolism, renal fibrosis, and the cardiovascular system.

Examples of animals that have successfully altered their development to accommodate human-made changes to their environments are explored and the ability of global warming to disrupt the development of those organisms with temperature-dependent sex-determination or with phenologies coordinating that organism's development with those of other species is documented.

The fundamental aspects of DNA storage and recent advances in this field are discussed, with special emphasis on natural processes and solutions that can be exploited, and new ways of efficient DNA and nucleotide storage are pointed out.

SUMMARY Acidocalcisomes are organelles conserved during evolution and closely related to the so-called volutin granules of bacteria and archaea, to the acidocalcisome-like vacuoles of yeasts, and to the lysosome-related organelles of animal species. All these organelles have in common their acidity and high content of polyphosphate and calcium. They are characterized by a variety of functions from storage of phosphorus and calcium to roles in Ca2+ signaling, osmoregulation, blood coagulation, and inflammation. They interact with other organelles through membrane contact sites or by fusion, and...

The reported chemical biology and computational biology techniques for identifying different types of targets that can provide valuable insights for drug target discovery are reviewed.

This perspective sketches out how systems biological thinking might enrich the training of a new generation of scientists in different fields of scientific endeavor.

Growing knowledge of the central biological roles of vasopressin has enabled pharmacological advances to treat these conditions by targeting defective systemic or central pathways utilizing specific agonists and antagonists.

How cellular ferritin localization is tightly linked to its function in a tissue-specific manner, and how impairment of iron homeostasis is implicated in diseases including cancer and COVID-19 are discussed.

The discovery of PCSK9, its structure–function characteristics, and its presently known and proposed novel biological functions are reviewed, namely its implication in septic shock, vascular inflammation, viral infections, and immune checkpoint modulation in cancer via the regulation of the cell surface levels of the T-cell receptor and MHC-I.

AlphaFold is the most ground‐breaking application of AI in science so far; it will revolutionize structural biology, but caution is warranted.

An introduction to plant biology is one of the literary work in this world in suitable to be reading material and it will show you the amazing benefits of reading a book.

Abstrak. Desa Botubarani merupakan desa wisata dengan daya tarik utamanya yakni wisata hiu paus (Rhincodon typus) atau whale shark. Kegiatan wisata yang berlangsung diharapkan dan diupayakan terus berkembang serta memberikan manfaat bagi masyarakat setempat. Agar ekowisata ini tetap terjaga eksistensinya, diperlukan keterlibatan masyarakat dalam pengembangan ekowisata. Tujuan penelitian ini yaitu untuk melihat tingkat partisipasi dan bentuk-bentuk partisipasi masyarakat dalam pengembangan ekowisata Hiu Paus Desa Botubarani. Metode yang digunakan dalam penelitian ini adalah metode deskriptif da...

This narrative review portrays the lymphatic system, a poorly understood but important physiological system, and proposes that future studies should aim at investigating aspects that are related to fluid regulation, hemodynamic responses, and endothelial and/or vascular changes due to lymphedema and lyMPhedema therapy.

An overview of the involvement of ferroptosis in nephrology is provided to introduce this expanding field for clinically versed nephrologists in the hope of spurring future efforts to prevent ferroptosis in the pathophysiological processes of the kidney.

The current state of knowledge related to populations within the Chernobyl region of Ukraine and Belarus following the largest civil nuclear accident in history is reviewed.

A survey of fishes from the Saint Peter and Saint Paul Archipelago was barcoded using the COI marker, which allowed the identification of 21 species, paving the way to further investigate the fish biodiversity of the archipelago, transitioning from barcoding to metabarcoding analysis.

The clinical biology of pituitary adenomas, and particularly their benign nature, stands in marked contrast to other tumors of the endocrine system, such as thyroid and neuroendocrine tumors.

The role of the tick’s salivary glands in secreting a remarkably complex array of anti-hemostatic molecules that modulate the bite site in the host skin and how these salivARY molecules facilitate the lengthy blood-sucking process is highlighted.

The functional roles of inosine in biology and their connections to human health are reviewed.

A review of complement biology and its mechanisms of activation in hematological diseases focusing on paroxysmal nocturnal hemoglobinuria and atypical hemolytic and uremic syndrome.

A perspective summarizing current scientific and therapeutic challenges as well as practice-changing opportunities for the PDAC field at this major inflection point is provided.

Not a single expert could imagine that the global pandemic was just weeks away, and that the most critical weapon the authors would have in the fight against the spread of the coronavirus would be social distancing and mask wearing.

This paper provides a comprehensive review of the role of melanocytes in skin biology and in-depth analysis could open novel avenues for research aimed at the prevention and treatment of skin disorders.

The factors involved in the emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic are discussed, indicating what can be learned from this public health emergency, and what can be applied to the Brazilian scenario.

Thomas Südhof discusses the cell-biological principles underlying the assembly of specific synaptic connections with defined properties that control neural circuits.

The concept and development of collagen hybridization is described, the decades of chemical investigations on rules underlying the collagen triple-helix folding are summarized, and the growing biomedical evidence on collagen denaturation as a previously overlooked ECM signature for an array of conditions involving pathological tissue remodeling and mechanical injuries is discussed.

The potential role of AQPs during the development of genomic instability is discussed and modeling is performed to describe the integration of binding between AQPs with various SH3 domain binning adaptor molecules.

The diverse mechanisms and molecules based on induced proximity, including protein degraders, blockers, and stabilizers, inducers of protein post-translational modifications, and agents for cell therapy are outlined.

Crosslinking mass spectrometry (XL‐MS) is an emerging technique capable of capturing transient and dynamic information on protein interactions and assemblies in their native environment and holds potential for bridging the gap between structural biology and systems biology approaches.

The role of neutrophils as conduits for periodontal-systemic disease connections and for oxidative damage to act as a causal link between the two has only recently been realized.

Rx3 is the first ever public high-content screening dataset combining genome-scale CRISPR knockouts with multiple-concentration screening of small molecules (a set of FDA approved and commercially available bioactive compounds) and is one of the largest collections of cellular screening data.

This review/perspective attempts to connect molecular, cellular, and physiological pathways in circadian biology to clinical consequences in stroke and Accounting for the complex and multifactorial effects of circadian rhythm may improve translational opportunities for stroke diagnostics and therapeutics.

The hypothesis that endometriosis risk is driven by low prenatal testosterone, and involves extreme expression of some reproductive phenotypes, is supported by a suite of evidence from genetics, development, endocrinology, morphology and life history and provides insights into why these two diametric, fitness-reducing disorders are maintained at such high frequencies in human populations.

It is proposed that this dual functionality is pivotal to the evolution of fungal symbionts, enabling persistence in environments otherwise hostile to fungi while simultaneously imposing costs on growth.

Preliminary evidence is found that hippocampal-based pattern separation and prefrontal-based cognitive control functions protect against the development of pathological fears in the aftermath of singular, event-type stressors, including simpler forms of post-traumatic stress disorder, PTSD.

The relationships between pyroptosis, apoptosis, and necroptosis are described, the key molecules in PANoptosome formation and PANoptosis activation are highlighted, and the multifaceted roles of PANoptotic roles in diseases together with a potential for therapeutic targeting are outlined.

This review summarises the latest progress in quantum biology, including the areas of enzyme-catalysed reactions, photosynthesis, spin-dependent reactions, DNA, fluorescent proteins, and ion channels, including many of these results are expected to be fundamental building blocks towards understanding the rules of life.

This study compares a number of verification tools and software suites used to analyse biological systems and biochemical networks, and to verify a wide range of biological properties, and presents a novel methodology that allows users to easily apply formal verification techniques to analyse their biological or biochemical system of interest.

The structure-activity relationships were analyzed in order to pave the way for future development and utilization of piperine and its derivatives as potent drugs and pesticides for improving the local economic development.

By causing an increase in pro-inflammatory signaling events, cell lysis (generating antigens) and attraction and activation of antigen presenting cells, defensins could have a relevant role in activating the adaptive immune system and generating anti-tumor immunity, and could thus contribute to the success of immune therapy.

The numerous and various recent studies that address attempts to destroy an already-formed biofilm within the clinical context are summarized as a potential therapeutic strategy to avoid the removal of infected implant material, a critical event for patient convenience and health care costs.

How genome-scale metabolic models (GEMs) can advance the understanding of the microbe–microbe and microbe-host interactions and synergies between system biology approaches and synthetic biology can be harnessed in human microbiome studies to improve future therapeutics and diagnostics are evaluated.

All living things are related to one another [...], and theorems showing this connection are described.