Top Research Papers on Dopamine

A large body of research on dopamine as a mediator of antipsychotic drug action and putative roles for this transmitter in the pathophysiology of schizophrenia is studied.

Ingrid Wickelgren's Special News Report “Getting the brain's attention” presents the views of those who question the current orthodoxy that dopamine acts in the nucleus accumbens as a key neurotransmitter underlying the behavioral effects of positive reinforcement.

The main roles of dopamine, a neuromodulator that originates from small groups of neurons in the mesencephalic dopamine centers, are summarizes with respect to recent modeling approaches.

This article traces the career of a scholarly reference point in political and administrative fields in an attempt to explain the processes that enable the use of an “idea” for political ends. It is important to study the circulation and appropriation dynamics that make a scientific concept available to political and/or administrative actors, and to understand how it can be referenced to a political issue, an advocacy, or a public policy. This case-study shows how dopamine (considered as the neurotransmitter of addictions) contributed to an important shift in French drug policies at the end of...

As Parkinson's disease progresses, nerve cells compensate for the death of neurones by increasing the number of connections they make, but Malcolm Horne has found that an accompanying tenfold increase in the production of the neurotransmitter dopamine sends the disease spiralling out of control.

Application of homology screening approaches has revolutionised the search for novel G protein-coupled receptors and there is a need for the development of antagonists specific to the new dopamine receptors.

Other psychiatrists seem less reticent about offer ing explanations for this strange symptom. Arieti (1974) summarises thus a case originally reported by another investigator: “¿ Reitman (1951) reported a patient who thought that as a private in the army he had a dog's life. While on parade he disclosed his manifest outbreak of schizophrenia. He suddenly went on all fours and started to bark. His thought †̃¿ I am treated like a dog' became †̃¿ I am a dog', and consequently he acted as a dog.― Arieti, thus, discusses the symptom as the behav ioural manifestation of concreteness of think...

This chapter will focus on the mesencephalic do14 pamine centers because they are the most studied, and are thought to be involved in diseases such as Tourette's syndrome, schizophrenia, Parkinson's disease, Huntington’s disease, drug ad17 diction, and depression.

Her Parkinson's symptoms initially worsened but improved in response to adjuvant low-dose levodopa/carbidopa treatment, and her interest in gambling decreased.

The neurotransmitter dopamine (DA) is generally associated with Parkinson's disease (PD) [...].

This work suggests that DA cells multiplex information about reward bonuses, including Sutton's exploration bonuses and Ng et al's non-distorting shaping bonuses, having the computational role of guiding exploration.

An alternative interpretation is allowed, namely that the drug-induced increase in dopamine is part of an aversive reaction to toxic substances, and this interaction could be a basis for economic decision-making by weighing costs vs. benefits.

Steady-state analysis of the factors involved in hormonal control of plasma cakium shows the effect of plasma calcium concentration on hormone secretion and bone transfer functions on the net transfer of calcium out of bone.

It is proposed that HVA in the QMP mixture may interact directly with dopamine receptors in the bee nervous system, perhaps decreasing the expression of dopamine receptors, thus altering the response of the neurons to endogenous dopamine.

The Dopamine Control of Sleep and Arousal and a Circuit Dynamics Theory of Complex Dopaminergic Modulation of Prefrontal Cortical Activity and its Relevance to Schizophrenia are studied.

Evidence increasingly suggests that dopaminergic neurons play a more sophisticated role in predicting rewards than previously thought, and this work has implications for how reward-seeking behaviour is understood and punished.

By virtue of its dual role as a neurotransmitter and a hormone, DA provides perhaps the best example of neuroendocrine interactions and it also possesses a more universal property.

The aim of the present chapter is to summarize data on the contribution of DA in the pathogenesis of many conditions such as Parkinson’s disease, Schizophrenia, Attention Deficit Hyperactivity Disorder and addiction.

Rezultati brojnih pretklinickih, „post-mortem“, te “imaging” studija ukazuju na tri osnovna patofizioloska mehanizma u shizofreniji: dopaminsku disfunkciju, poremecenu transmisiju u glutamatnom sustavu, te upalniproces u mozgu. Ova tri sustava se nalaze u stalnoj međusobnoj interakciji. Dopamin ima kljucnu ulogu u brojnim funkcijama sredisnjeg živcanog sustava, poput voljnih pokreta, spavanja, dnevnog ritma, aktivnosti, ponasanja, uzimanja hrane, doživljaja nagrade, donosenja odluka, radne memorije, ucenja, motivacije, pozornosti, afekta, te hormonalne regulacije. Dopaminska hipoteza shizofren...

New findings are revealed revealing a gradual increase in the firing rate of midbrain dopamine neurons in anticipation of uncertain rewards, which may serve to heighten attention during uncertainty, thus promoting the learning of better predictors of reward.