Top Research Papers on Genetics

This article focuses on the recent development in maintaining the diversity of genetic resources, their conservation, and their sustainable utilization to secure global food security.

It was found that the shrimp from Mono Lake and from Sete were reproductively isolated from each other and from the other seven populations, however, there was no barrier to gene exchange among these populations.

A comparison between four Genetic Programming techniques is presented, revealing that Multi-Expression Programming has the best overall behavior for the considered test problems, closely followed by Linear Genetic Programming.

The fourth edition of this popular textbook retains its focus on the fundamental principles of gene manipulation, providing an accessible and broad-based introduction to the subject for beginning undergraduate students. It has been brought thoroughly up to date with new chapters on the story of DNA and genome editing, and new sections on bioethics, significant developments in sequencing technology and structural, functional and comparative genomics and proteomics, and the impact of transgenic plants. In addition to chapter summaries, learning objectives, concept maps, glossary and key word lis...

COGA was designed during the linkage era to identify genes affecting the risk for alcohol use disorder (AUD) and related problems, and was among the first AUD‐focused studies to subsequently adopt a genome‐wide association (GWAS) approach.

This work studied how human life depends on the genes, i.e., the genetic-dependence, which was classified as genetic-dependent nature (GDN, vital consequence of abolishing a gene), genetic- dependence quantity (GDQ, quantitative genetic function required for normal life), and genetic- dependent stage (GDS, temporal expression pattern).

An innovative model is proposed to improve the accuracy of lost of life transfomer prediction using stacking ensembles enhanced with genetic algorithm (GA), and the developed framework presents a promising solution for accurate and reliable transformer life prediction.

While genetic screening tests do not provide a conclusive answer, they can help guide next steps, such as whether additional, diagnostic testing is needed.

Banana is an important food security crop for millions of people in the tropics but it faces challenges from diseases and pests. Traditional breeding methods have limitations, prompting the exploration of precision genetic tools like genetic modification and genome editing. Extensive efforts using transgenic approaches have been made to develop improved banana varieties with resistance to banana Xanthomonas wilt, Fusarium wilt, and nematodes. However, these efforts should be extended for other pests, diseases, and abiotic stresses. The commercialization of transgenic crops still faces continuo...

The epidemiological trends and risk factors of HCC are evaluated, the genetics of H CC are discussed including monogenic diseases, single-nucleotide polymorphisms, gut microbiome, and somatic mutations, and the transition from viral to non-viral causes is discussed.

1. Genetics and Ecotoxicology - Insights from the Interface Valery Forbes 2. The Evolution of Heavy Metal Tolerance in Plants: Adpatations, Limits, and Costs A. Johnathan Forbes 3. Mercury Tolerance, Population Effects, and Population Genetics in the Mummichog, Fundulus heteroclitus Judith Weis, Nicolay Mugue, Peddrick Weis 4. Chemical-Induced Changes in the Genetic Structure of Populations - Effects on Allozymes Robert Gillespie and Sheldon Guttman 5. Adaptation to Metals in the Midge, Chironomus riparius - a Case Study in the River Dommel Jaap Postma and Dick Groenendijk 6. The Influence of ...

Interestingly, approximately 37% of candidate genes are shared in human male and female gonadal failure, implying that genetic counselling should be extended also to female family members of NOA patients, and of potential clinical relevance for future gene panel-based screening.

This work permuted the rules by which genetic information is encoded in DNA and thereby created genetically isolated organisms that cannot exchange functional genetic information with other organisms, providing a new paradigm that both protects valuable engineered organisms from natural invaders and safeguards the natural world from engineered genetic material.

Here, it is synthesized how considering the effects of these adaptive loci in the context of cellular environments, genomes, organisms, and populations has provided new insights to the genetic architecture of adaptation.

A systematic review of the PubMed medical literature published since 2003 found 74 studies in which self-reported race alone or in combination with admixture mapping was used to define the study population, but none of these studies provided a genetic explanation for the use of the self-identified race as a genetic category and only seven proffer evolutionary explanations of their data.

It is argued that these terms are imprecise and potentially misleading and that, for most applications, simple statements of genetic similarity represent a more accurate description.

New additions are described that make MEGA a more comprehensive tool for building timetrees of species, pathogens, and gene families using rapid relaxed-clock methods and a Bayesian method for estimating neutral evolutionary probabilities of alleles in a species using multispecies sequence alignments.

It is argued that in depth understanding of cancer progression from the evolutionary perspective may allow the prediction and direction of the evolutionary path of cancer populations towards drug sensitive phenotypes and thus facilitate the development of more effective anti-cancer approaches.

Examining AI's potential significance in advancing precision genetic disease treatment is examined, a peek at its use in genetic clinical care is provided, a clinician primer on critical aspects of these technologies is provided, and predictions about AI's potential future applications in genetic illnesses are made.

The use of genetic algorithms in many fields is demonstrated in this study along with how they may be integrated with a number of other approaches to arrive at the best possible solution and speed up information retrieval systems.

The epidemiology of FH is summarized based on numerous genetic studies, including its pathogenic variants, genotype–phenotype correlation, prognostic factors, screening, and usefulness of genetic counseling and genetic testing.

Various aspects of human infertility are reviewed, including etiology, mechanisms, and treatments, with a particular emphasis on genetics, including gamete production and gamete quality, which is the core of successful reproduction.

This review explores the causes of the rapid spread of C. auris and highlights its genome organization and drug resistance mechanisms and proposes future research directions that should be undertaken to curb the spread of this multidrug-resistant pathogen.

Despite its complex architecture, insights from experimental genetic dissection coalesce to reveal unifying biological themes, including synaptic, lysosomal, mitochondrial, and immune-mediated mechanisms of pathogenesis.

Current knowledge of genetic and epigenetic mechanisms leading to ABCB1 upregulation and P-gp-enhanced ATPase activity in the setting of chemotherapy resistance across a variety of cancers is summarized.

WIC-eligible women with unintended pregnancies and fewer social supports tend to participate in WIC, but those who experience more structural barriers are less likely to participate, while A/PI women may face specific challenges to WIC participation.

This review was conducted to provide guidance to clinicians caring for patients with dementia regarding clinically relevant genetics.

The latest efforts and advances in identifying and decoding asthma susceptibility are focused on epigenetics, heritable characteristics that affect gene expression without altering DNA sequence, with DNA methylation being the most described mechanism.

Evidence suggests an important role for adaptive cell plasticity and non‐genetic mechanisms in the development of therapy resistance, and a broader characterization of the genetic and non‐genetic mechanisms of drug resistance may pave the way for more precise and effective therapeutic strategies to overcome resistance.

The “Nosology of genetic skeletal disorders” has undergone its 11th revision and now contains 771 entries associated with 552 genes reflecting advances in molecular delineation of new disorders thanks to advances in DNA sequencing technology. The most significant change as compared to previous versions is the adoption of the dyadic naming system, systematically associating a phenotypic entity with the gene it arises from. We consider this a significant step forward as dyadic naming is more informative and less prone to errors than the traditional use of list numberings and eponyms. Despite the...

GC involvement was associated with increased documentation of most pre‐ and post‐test genetic counseling variables, and with increased emphasis placed on transparency, accurateness, and access for patients of the EMR, documentation should reflect the content of counseling provided.

If one could rationally expand the set of amino acid building blocks, one could add new chemistries to proteins—both as biological probes, as well as to create proteins with novel functions, to explore the chemistry–biology interface.

A perspective summarizing current scientific and therapeutic challenges as well as practice-changing opportunities for the PDAC field at this major inflection point is provided.

This review aims to analyze the new genetic findings that are closely related to the pathophysiology of AD and analyzes the multiple mutations identified to date through GWAS that are associated with a high or low risk of developing this neurodegeneration.

Recent progress in the genetics and molecular pathogenesis of PGLs are reviewed and new prospects for advancing research with new disease models and ongoing clinical trials presented at the recent International Symposium of Pheochromocytomas and Paragangliomas are discussed.

Various developments in genetic diagnostic technologies and strategies are discussed, which highlight the revolutionizing shift in clinical practice from a phenotype-first into genotype-first approach in the field of ID.

A comprehensive overview of the fundamental principles and delivery methods of cytosine base editors (CBE), adenine base editors (ABE), and RNA base editors, with a particular focus on their applications and recent research advances in the treatment of genetic diseases.

A survey of fishes from the Saint Peter and Saint Paul Archipelago was barcoded using the COI marker, which allowed the identification of 21 species, paving the way to further investigate the fish biodiversity of the archipelago, transitioning from barcoding to metabarcoding analysis.

The current understanding of disparities in genetic testing for people with ovarian cancer, the role of population-based genetic testing, and innovative strategies to overcome the critical inequities present in current cancer genetic medicine are reviewed.

Different forms of dystonia can be molecularly grouped, which may facilitate treatment development in the future and help understand shared pathophysiological pathways and molecular mechanisms.

Family, population, and twin studies all support a role of genetics in the development of strabismus, and the recent advances that have been made in the genetics of comitant strabistismus are reviewed.

To establish a foundation for a better understanding of the genetics and epigenetics of keloids, current studies which are mostly related to heredity, genetic polymorphisms, predisposing gene, DNA methylation and non‐coding RNA are evaluated and summarized.

In 2013, the ALzheimer's and FAmilies (ALFA) project was established to investigate pathophysiological changes in preclinical Alzheimer's disease (AD), and to foster research on early detection and preventive interventions.

Empirically defensible xenotransplantation should entail the use of genetic disenhancement if it becomes possible to do so and if that pain and suffering cannot be eliminated by other means.

Mood disorders are highly heritable psychiatric disorders. Over the years, many genetic polymorphisms have been identified to pose a higher risk for the development of mood disorders. To overview the literature on the genetics of mood disorders, a scientometric analysis was performed on a sample of 5342 documents downloaded from Scopus. The most active countries and the most impactful documents in the field were identified. Furthermore, a total of 13 main thematic clusters emerged in the literature. From the qualitative inspection of clusters, it emerged that the research interest moved from a...

Population genetic parameters and genetic trends for 67 traits evaluated on heifers and first-lactation Canadian Holstein cows collected from 1980 to 2019 are estimated using bivariate linear animal models under a Bayesian approach.

Three hypotheses are drawn from social psychological research to formulate three hypotheses that build on each other in order to introduce the “Nurtured Genetics” effect along with the psychosocial implications it entails.

The main molecular alterations found in pancreatic neoplasms and GEMMs developed based on these alterations are summarized and the categorization of altered driver genes according to the most updated findings are modified.

The factors involved in the emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic are discussed, indicating what can be learned from this public health emergency, and what can be applied to the Brazilian scenario.

Genome-wide association studies (GWAS) or genetic data analysis is used to discover common genetic factors which influence the health of human beings and become a part of a disease. The concept of using genomics has increased in recent years, especially in e-healthcare. Today there is huge improvement required in this field or genomics. Note that the terms genomics and genetics are not similar terms here. Basically, the human genome is made up of DNA, which consists of four different chemical building blocks (called bases and abbreviated A, T, C, and G). Based on this, we differentiate each an...