Top Research Papers on Genetics

The author's purpose was to give a simple account of a large amount of material with the hope of encouraging research on the infectious nature of cancer, which is clearly written and well organized, with schematic drawings and photographic illustrations which are an integral part of the text.

Although currently genetic testing is not likely to yield a diagnosis for most patients with GGEs, it can be of great importance in specific clinical situations and providers should consider the individual patient's history in determining the utility of genetic testing.

The white paper wants to incorporate genetics advances into everyday clinical practice and proposes a partnership model, in which primary care physicians and geneticists learn from each other, as envisaged by Burke and Emery.

Quantitative behavioral genetics and molecular genetics are the two methodological approaches within behavioral genetics that aim to address the origins of observed differences among individuals.

Genetics at the Level of the Individual: transmission genetics: the rules of inheritance and Prospects for genetic engineering in domestic animals.

It is argued that more comprehensive analysis and Bayesian reasoning are needed and can overcome some of these pitfalls, although not in every conceivable case.

It is argued that the Genetic code is a relation rather than a mapping, and a generalized genetic code is tentatively proposed, and this view is shown to be supported by the symmetry analysis.

It is argued, why this traditional approach to genetic research should be supplemented or even replaced by modeling approaches in accordance with the complexity of biological systems, if any reasonable hope is to understand the genetics behind any trait and bring genetics into practical use in medicine for common diseases.

Some of the common genetic issues that arise in general practice clinical consultations, and the clinical scenarios in which general practitioners (GPs) may suggest genetic testing for patients or referral to one of the various specialist genetics services are outlined.

The difference in linkage signals detected in Caucasian versus Chinese families suggests that different genes may be involved in the pathogenesis of generalized vitiligo in different ethnic populations.

Validity measures how well a string satisses the constraints and the structure of genetic algorithm is modiied to incorporate the validity of strings to show that this theory has promise.

The purpose of this article was to review the electroclinical spectrum of those epilepsies that would fall under this new designation of genetic epilepsy in the context of specific generalized epilepsy syndromes providing an update in the clinical, electroencephalographic, and genetic findings in these syndrome.

It is anticipated that the discovery of biological pathways of Vitiligo pathogenesis will provide novel therapeutic and prophylactic targets for future approaches to the treatment and prevention of vitiligo and its associated autoimmune diseases.

I shall, in general, follow the lead of many professionals in the field by interpreting "bacteria" to mean Escherichia coli K-12 and its close relatives.

Improvements to the use of genetic algorithms to compose music are examined, including adding a mechanism for generating files from the composition, expanding the complexity of a melody to include multiple simultaneous notes, and expanding the evolutionary processes used for the melody composition.

This work uses a physiologically inspired pulse-coupled neural network to find salient regions in an underlying image, and by subsequently introducing a motif function into the genetic programming system, is able to augment the paradigm to introduce thematic image regions.

This commentary starts by looking at those very rare children with either a complete inability to sense pain, or who suffer intermittent severe pain, who usually have Mendelian single gene disorders.

It is shown that it is possible to form a symbiosis between a directed specialization and a genetic generalization mechanism achieving a learning mechanism that evolves a complete, accurate, and compact description of a perceived environment.

The motivation for this work is to create personalized maps containing familiar information (well-known places) to the user in order to improve the map readability, thus leading to a spatial generalization problem.

This work presents a Generalized Crowding approach that allows selective pressure to be controlled in a simple way in the replacement phase of crowding, thus overcoming limitations of the other approaches.

The article focuses on the tragic fate of genetics in the Soviet Union during Staline's regime and on efforts of the Institute's founder – academician Nikolai Ivanovich Vavilov and his followers to promote an international level genetic studies within the Institute.

The introduction of genetics as part of the new Royal College of General Practitioners curriculum for general practice, which comes into force in August 2007, is a welcome move and reinforces the importance of genetics across the range of healthcare and the central role that primary care must play in this both now and in the future.

A complete generalization of the Vose genetic algorithm model from the binary to higher cardinality case is provided, with Boolean AND and EXCLUSIVE-OR operators replaced by multiplication and addition over rings of integers.

The pediatrician must be knowledgeable regarding the general principles of genetics and their application to common diseases and be aware of specific recommendations including newborn screening and carrier detection.

A general model is proposed for genetic recombination, which proposes the hypothesis that recombination is initiated by a single-strand (or asymmetric) transfer, which may, after isomerization, become a two-stranded exchange.

University of Minnesota Ph.D. dissertation. May 2013. Major: Psychology. Advisors: Matthew McGue, Niels Waller. 1 computer file (PDF); v, 140 pages.

Today many adults are offered genetic counseling to help them make reproductive decisions, either before they attempt to achieve a pregnancy or tohelp them decide whether to continue or terminate one.

My system uses an interactive genetic algorithm to learn a user's criteria for the task of generating musical rhythms, and develops an increasingly accurate model of the function which represents the user's criterion, so that the quality of the rhythms it produces improves to suit the users' taste.

It is necessary to realize the limitations of cytological data as criteria of the generations, since some workers have unconsciously tended to regard the two generations as separate entities rather than developmental phases of a single one.

Genome-wide studies examining common genetic risk factors identified common variants in SCN1A, indicating a convergence of shared pathophysiological pathways in various types of epilepsies, prompting a strong impetus for large collaborative investigations on an international level.

The remarkable advances in genetics and genomics that have occurred over the last few years are beginning to impact clinical care in cardiovascular medicine, including whole exome or genome sequencing.

The current understanding of SLE genetics is outlined, in particular summarising the results of recent association studies, and several candidate genes with diverse immunological function are identified.

The idiopathic generalized epilepsies (IGEs) are considered to be primarily genetic in origin and progress in understanding the non‐mendelian IGEs should lead to new approaches to diagnosis and treatment.

En este trabajo se presenta un método original para el ensamblado de acelerogramas compatibles con un espectro objetivo preestablecido. El procedimiento se basa en un generador de señales sísmicas, el cual toma en consideración las características del evento sísmico y las condiciones del subsuelo para hacer una representación realista de los movimientos del terreno. Se utilizan operadores genéticos para transformar en forma iterativa los acelerogramas, imitando los procesos de apareamiento, selección natural y mutación. El generador de señales sísmicas genéticas, modifica los componentes de ac...

Experimental results with typical problems showed that the genetic algorithms with competitive generation are superior to those without the competitive generation.

Learning concepts from traditional machine learning and a brief review of research on generalization in GP are presented and a method for promoting robustness/generalization of the solutions in simulating learning behaviors using GP is suggested.

New developments in Gray Box Optimization makes it possible to construct new forms of Genetic Algorithms that do not use random mutation or random recombination for certain classes of NP Hard problems.

A generic genetic algorithm expressed in the functional programming style, specifically the language Haskell, is presented that can encapsulate the functionality of almost any genetic algorithm, and is accompanied by a library of standard GA components.

The final author version and the galley proof are versions of the publication after peer review that features the final layout of the paper including the volume, issue and page numbers.

Ada itself provides both challenges and advantages: linked-lists must be well understood to be updated in an object-oriented context and hard-typing produces mixed reactions in students used to C++, but generics provide a powerful way to generalize the algorithm and incorporating different problem domains.

Typical EEG features of GGE significantly simplify the differential diagnosis of electroclinical syndromes and reveal the peculiarities of epileptiform discharges distribution.

GP consultations involving the new genetics will include diagnostic testing for patients with clinical problems, preconception and prenatal testing for couples in relation to pregnancy, predictive testing for families with some genetic conditions, and community genetic screening in some circumstances.

A model is proposed to characterize the means of a fixed set of varieties, variety crosses and other entries obtained from these varieties and variety crosses. The varieties can be pure-line varieties, inbred lines with any degree of inbreeding as well as open-pollinated or synthetic varieties as long as the varieties are in Hardy-Weinberg equilibrium. Parameters are defined for additive, dominance and additive by additive epistatic effects assuming diploid inheritance. Tests are available from the analysis of variance for deviations due to higher order epistasis (and/or linkage with additive ...

The final author version and the galley proof are versions of the publication after peer review that features the final layout of the paper including the volume, issue and page numbers.

Using dominant negative allele of a mismatch repair gene human to generate genetic diversity in a gene encoding a therapeutic agent is useful for the production of altered polypeptides with enhanced antigen and immunogenic activity.

The past 4 years have seen tremendous developments in human genetics of complex diseases, and single nucleotide polymorphism chips have been developed, which allows testing hundreds of thousands (or even millions) of polymorphisms (SNPs) in a single experiment in an individual.

The work of Moor House School deserves every encouragement, and it is to be hoped that it will extend its field of research to all branches of speech therapy.

The compositions and methods for using TALEN generating a genetically modified livestock may include selecting as progenitor cells or embryos for generating the founder animals reporter.

My role as a Dutch general practitioner in caring for patients with genetic disorders is analysed and this with some examples is described.

This "Deep Insight" is a detailed subchapter of a general review article and summary on Internet databases for cytogeneticists: Internet databases and resources for cytGenetics and cytogenomics.