Top Research Papers on Genetics PDF

COGA was designed during the linkage era to identify genes affecting the risk for alcohol use disorder (AUD) and related problems, and was among the first AUD‐focused studies to subsequently adopt a genome‐wide association (GWAS) approach.

A systematic review of the PubMed medical literature published since 2003 found 74 studies in which self-reported race alone or in combination with admixture mapping was used to define the study population, but none of these studies provided a genetic explanation for the use of the self-identified race as a genetic category and only seven proffer evolutionary explanations of their data.

Overall, this study presents that the “Psychiatric Genetic Counseling for Genetic Counselors” workshop fulfilled its proposed aims and outcomes.

The use of genetic algorithms in many fields is demonstrated in this study along with how they may be integrated with a number of other approaches to arrive at the best possible solution and speed up information retrieval systems.

In 2013, the ALzheimer's and FAmilies (ALFA) project was established to investigate pathophysiological changes in preclinical Alzheimer's disease (AD), and to foster research on early detection and preventive interventions.

It is indicated that genetic factors are the most common cause of hearing loss regardless of ethnic background and saliva-based genetic testing is a useful tool for multi-center studies seeking to clarify the genetic causes of hearing loss in CI or EAS patients between countries separated by distance.

It is shown that Fagaceae offers exceptional opportunities for evolutionary investigations because of its diversity at both the phenotypic and genetic levels and existing documented genome sequences.

Approximately half the total participants possessed an inadequate understanding of cancer genetics and of the importance of genetic testing among the general population in Saudi Arabia’s Makkah Province, indicating the need for awareness campaigns and programs to improve the generalpopulation's understanding of the genetic predisposition to cancer.

The Genetics of Glaucoma Study (GOGS) is established to identify disease genes and improve genetic prediction of glaucomA risk and response to treatment, and to develop or validate genetic risk prediction models to stratify glAUcoma risk and to predict clinical outcomes.

The existence of moral distress in the genetic counseling field is established and the need for coping strategies and recommendations in order to alleviate future genetic counselor moral distress is supported.

This article focuses on the recent development in maintaining the diversity of genetic resources, their conservation, and their sustainable utilization to secure global food security.

The DGAs are robust, have a high degree of consistency and perform better, sometimes almost twice as well, than the HGAs, but are slower due to the high number of operations to be performed, caused by the duplication of the genetic information.

This research presents a novel probabilistic approach to estimating the response of the immune system to laser-spot assisted, 3D image recognition technology.

This work studied how human life depends on the genes, i.e., the genetic-dependence, which was classified as genetic-dependent nature (GDN, vital consequence of abolishing a gene), genetic- dependence quantity (GDQ, quantitative genetic function required for normal life), and genetic- dependent stage (GDS, temporal expression pattern).

A group of expert stroke and rehabilitation clinicians and researchers with knowledge in genetics of stroke recovery here present recommendations for harmonizing phenotype data with focus on measures suitable for multicenter genetic studies of ischemic stroke brain injury and recovery.

It was found that the shrimp from Mono Lake and from Sete were reproductively isolated from each other and from the other seven populations, however, there was no barrier to gene exchange among these populations.

This study presents a comprehensive survey of the GA and provides and discusses genetic algorithms for new researchers and illustrates which components build up the GAs and view the main results on complexity time.

This overview provides the framework for the development of COGA as a scientific resource in the past three decades, with individual reviews providing in‐depth descriptions of data on and discoveries from behavioral and clinical, brain function, genetic and functional genomics data.

A patient who had suffered from severe ankyloblepharon that reached the central cornea in both eyes and underwent repeated superficial keratectomy and symblepharon lysis surgeries with amniotic membrane transplantation, and received B-VEC for his cutaneous wounds as well as ocular conditions showed durable wound healing.

The populations of the Belgorod region are characterized by high migration activity, which leads to a decrease in the level of endogamy among the population.

High heritability coupled with high genetic advance observed for number of branches plant indicating that they are governed by additive gene action and could be improved through simple selection.

Assessment of the pathogenicity of the genetic variants of PCD in indigenous patients with significant clinical respiratory problems in the United Arab Emirates defined potentially damaging PCD variants in the region.

The GCV, heritability and genetic advance as per cent of mean were high for fruit length, fruit girth and 10-fruits weight indicating additive gene action which contributed maximum divergence and played major role in improvement of brinjal yield.

This work analyzes two population genetic models that allow for a spatially structured population in a continuous habitat and suggests that the optimal choice of genetic distance is based upon splitting a DNA sequence into segments and counting the number of segments at which two sequences differ.

This study attempts to collect, organize, and present in a unified way some of the most representative publications on parallel genetic algorithms, including a categorization of the techniques used to parallelize GAs.

Identification of the genes located in candidate regions will pinpoint the genetic risk factors, will lead to a better understanding of the syndrome, and will provide clues for its prevention and treatment.

Clinical studies show that a family history of suicide is associated with a raised risk of both attempts at suicide and completed suicide, and molecular genetic studies report that polymorphisms of the tryptophan hydroxylase gene are associated with suicidal behavior.

Banana is an important food security crop for millions of people in the tropics but it faces challenges from diseases and pests. Traditional breeding methods have limitations, prompting the exploration of precision genetic tools like genetic modification and genome editing. Extensive efforts using transgenic approaches have been made to develop improved banana varieties with resistance to banana Xanthomonas wilt, Fusarium wilt, and nematodes. However, these efforts should be extended for other pests, diseases, and abiotic stresses. The commercialization of transgenic crops still faces continuo...

The present study was carried out on data of 3,425 Frieswal cattle (Holstein Friesian × Sahiwal cattle) maintained at Military Farm, Pimpri, Pune, Maharashtra. Total 9,094 lactation records were collected from 3,425 cows born to 239 sires. The data were analyzed using SAS software. The collected data were normalized and utilized for studying effect of genetic and non-genetic factors on milk yield. The PROC GLM procedures of SAS were used to quantify the effect of non-genetic factors on milk yield. The non-genetic factors considered for the present study were period of calving, season of calvin...

The clinical severity of acute pancreatitis is unpredictable, ranging from self‐limiting disease to life‐threatening inflammation, and single nucleotide polymorphisms (SNP) associated with SAP are identified.

Abstract Background Gaming is a popular past‐time activity among children and adolescents, but it there is also a possible link to negative consequences such as psychological distress and lowered academic achievement. However, there are fundamental knowledge gaps remaining regarding central characteristics of gaming such as heritability, stability over time, and sex differences. We examined the genetic and environmental contribution to gaming behavior, including sex differences, continuity and change, in a longitudinal cohort of twins. Methods This is the first longitudinal twin study on gamin...

It is argued that these terms are imprecise and potentially misleading and that, for most applications, simple statements of genetic similarity represent a more accurate description.

Investigating the receptor gene expressions of the sex hormones and FGFR2, HOXA13, and TGFB1 suggested that sex hormone receptors andFGFR2 may play an essential role in developing male external genital structures at the gene level.

Tomato is one of the most significant vegetable crops, which provides several important dietary components. Pakistan has a significant low tomato yield compared to other countries because of low genetic diversity and the absence of improved cultivars. The present study aimed to investigate the genetic variability, heritability, and genetic advance for yield and yield-related traits in tomato. For this purpose, eight tomato parents and their 15 crosses or hybrids were evaluated to study the relevant traits. Significant variation was observed for all studied traits. Higher values of the genotypi...

An improved ridge approach for the genome regression modeling is developed and the good properties of generalized cross validation (GCV) are used to choose the optimum value of the ridge parameter.

In two distinct environments (E1 and E2), the current experiment was set up using a randomized block design with the goal of determining the extent of genetic diversity, heritability, and genetic advancement among 15 yield-related variables in brinjal. The analysis of variance results revealed that there were significant genetic variances across brinjal genotypes, indicating a significant degree of variability and boosting the opportunity for selection to improve the essential traits. There was a noticeable variance in mean values between the genotypes for several traits, from modest to wide. ...

LDSC analysis revealed significant genetic correlations between several autoimmune diseases and BE, and further MVMR analysis showed that RA is an independent risk factor for BE, whereas mediator MR analysis did not identify any mediating factors.

The risk to develop spondylarthropathy in HLA-B27+ relatives of patients decreased very rapidly in respect to the genetic distance, suggesting the genetic contribution of at least one other important gene distinct from the HLA region.

High heritability coupled with high genetic advance observed for the traits viz., Pods per plant, plant height, yield per plants, branches per plant and trypsin inhibitor content and 100 seed weight which indicates presence of additive gene action and demands for population improvement by selection.

While genetic screening tests do not provide a conclusive answer, they can help guide next steps, such as whether additional, diagnostic testing is needed.

The paucity of research on cancer genomics on African populations is highlighted, gaps in understanding the underlying genetic causes of, and genomic alterations associated with, cancer among black Africans are identified, and the need for concerted efforts to encourage more research in Africa is discussed.

Hundreds of genes whose variations contribute to human diseases, or patients’ responses to drug treatments or even to vaccination have been discovered, laying the foundation for a paradigm shift in healthcare.

Development of high yielding genotypes under such conditions require a thorough knowledge of genetic variation and yield contributing characters to exploit complete genetic variability to exercise selection for development of yield contributing traits.

Findings suggest that diapausing eggs in cyclical parthenogenetic Daphnia populations are produced by sexual reproduction and means and genetic variances for life history traits change significantly upon SR in the opposite direction to that promoted by the previous selection.

The epidemiology of FH is summarized based on numerous genetic studies, including its pathogenic variants, genotype–phenotype correlation, prognostic factors, screening, and usefulness of genetic counseling and genetic testing.

The Brisbane Systems Genetics Study (BSGS) is described, a family-based study that will be used to elucidate the genetic factors affecting gene expression and the role of gene regulation in mediating endophenotypes and complex diseases.

The fourth edition of this popular textbook retains its focus on the fundamental principles of gene manipulation, providing an accessible and broad-based introduction to the subject for beginning undergraduate students. It has been brought thoroughly up to date with new chapters on the story of DNA and genome editing, and new sections on bioethics, significant developments in sequencing technology and structural, functional and comparative genomics and proteomics, and the impact of transgenic plants. In addition to chapter summaries, learning objectives, concept maps, glossary and key word lis...

A meta-analysis of all available genetic association studies of Autism spectrum disorder (ASD) found 28 genetic polymorphisms have been shown to be associated with ASDs, that are harbored in 19 genes.

High heritability coupled with moderate genetic gain was observed for number of fruits per cluster, harvest duration and ascorbic acid content, therefore, these characters also show some scope for improvement in yield through selection in tomato.

This study examines a variety of selection strategies typically employed in contemporary genetic algorithms and their merits and downsides.