Top Research Papers on Genetics PDF

Fuzzy Logic, as its name suggests, is the logic underlying modes of reasoning which are approximate rather than exact, and has been shown to be an important tool for modelling complex systems, in which classical tools are unsuccessful.

It is pointed out in this paper that the science of genetics is capable of furnishing further contributions to the cancer problem, and that the study of the occurrence of spontaneous tumors in diverse stocks of pedigreed and unpedigreed animals, especially mice, is made possible.

To one who has watched day by day the growth and transformations of many butterflies, such a collection in spite of its beauty seems like a gorgeous mausoleum, one misses the reactions of the graceful live creatures in response to sunlight and shadow.

The results showed that the history of parents asthma was one of risk factors about offsprings asthma, and the risk was 4.0-8.0 times higher (P < 0.01), and the airway responsiveness of parents did not relate to the one of offSprings.

High value of heritability percentage was noted in parameters like plant height, fruit diameter, fruit size and fruit weight and there is high difference between GCV and PCV for the parameters like Number fruit per clusters, Number of flowers per cluster and yield per plant.

The author's purpose was to give a simple account of a large amount of material with the hope of encouraging research on the infectious nature of cancer, which is clearly written and well organized, with schematic drawings and photographic illustrations which are an integral part of the text.

Rare variants are likely to be a critical piece of the puzzle that needs to be solved to understand the genetic basis of complex lung disease and to use this information to develop better therapies.

Through studies about IGEs /CAE susceptibility genes, the pathogenic model of epilepsy genetics is determined, and the way to diagnose accurately in molecular genetics, to identify types of epilepsies, to detect targets of antiepileptic drugs, and provide a basis for gene therapy is found.

The degree of exposure to politically motivated attacks differed for these two experts; they nevertheless faced similar threats to their professional credibility and personal integrity when they publicized links between thalidomide and birth defects.

It is concluded that, although there are similarities in bone mineral content between the three generations, genetic factors cannot be conclusively proven to be the major determinant of bone density.

The segregating populations of six crosses were studied in F3 and F4 generations by using intraclass correlation and regression methods, heritability and genetic correlations involving five quantitative characters were worked out.

Although currently genetic testing is not likely to yield a diagnosis for most patients with GGEs, it can be of great importance in specific clinical situations and providers should consider the individual patient's history in determining the utility of genetic testing.

The white paper wants to incorporate genetics advances into everyday clinical practice and proposes a partnership model, in which primary care physicians and geneticists learn from each other, as envisaged by Burke and Emery.

Quantitative behavioral genetics and molecular genetics are the two methodological approaches within behavioral genetics that aim to address the origins of observed differences among individuals.

Genetics at the Level of the Individual: transmission genetics: the rules of inheritance and Prospects for genetic engineering in domestic animals.

It is argued that more comprehensive analysis and Bayesian reasoning are needed and can overcome some of these pitfalls, although not in every conceivable case.

It is argued that the Genetic code is a relation rather than a mapping, and a generalized genetic code is tentatively proposed, and this view is shown to be supported by the symmetry analysis.

It is argued, why this traditional approach to genetic research should be supplemented or even replaced by modeling approaches in accordance with the complexity of biological systems, if any reasonable hope is to understand the genetics behind any trait and bring genetics into practical use in medicine for common diseases.

Some of the common genetic issues that arise in general practice clinical consultations, and the clinical scenarios in which general practitioners (GPs) may suggest genetic testing for patients or referral to one of the various specialist genetics services are outlined.

The difference in linkage signals detected in Caucasian versus Chinese families suggests that different genes may be involved in the pathogenesis of generalized vitiligo in different ethnic populations.

Validity measures how well a string satisses the constraints and the structure of genetic algorithm is modiied to incorporate the validity of strings to show that this theory has promise.

The purpose of this article was to review the electroclinical spectrum of those epilepsies that would fall under this new designation of genetic epilepsy in the context of specific generalized epilepsy syndromes providing an update in the clinical, electroencephalographic, and genetic findings in these syndrome.

It is anticipated that the discovery of biological pathways of Vitiligo pathogenesis will provide novel therapeutic and prophylactic targets for future approaches to the treatment and prevention of vitiligo and its associated autoimmune diseases.

I shall, in general, follow the lead of many professionals in the field by interpreting "bacteria" to mean Escherichia coli K-12 and its close relatives.

Improvements to the use of genetic algorithms to compose music are examined, including adding a mechanism for generating files from the composition, expanding the complexity of a melody to include multiple simultaneous notes, and expanding the evolutionary processes used for the melody composition.

It is found that AM inflates genetic correlation estimates between health traits and education by 14% on average, and a simple, general-purpose approach using polygenic indexes (PGIs) can estimate the fraction of genetic variance and genetic correlation that is driven by AM.

Various genetic models will be detailed and generalized by mixed linear model approaches and the features of the new computer tool GenMod will be described.

This paper develops the generalization of the Manabe standard form, tries to find out the SRFS (slow rise time and fast settling time) form, and designs a controller for a given plant so that the overall system has the performance that the rise time is faster and the settling time is slower than those of the Woman's standard form.

The whole series of studies demonstrate how NGS can be applied in studying the genetic basis of complex disorders and assisting in follow-up functional studies in model organisms.

The acute toxicity of the test item was investigated in rats after single oral, dermal and inhalation applications and metaphase chromosome aberration assay was performed on CHO cell line to check the structural chromosome aberrations.

The goal is to create a user-friendly, effective, and straightforward application that facilitates the process of creating and distributing timetables that avoids complex manual processes to set up and manage timetables.

In order to investigate the law of the unstability during the evolutionary process in genetic algorithms, two novel concepts of the truncated generation and the distribution of truncated generations are presented and their definitions are detailed.

Twenty‐six combinations of C57BL/10 congenic mice involving incompatibilities in the I region and the H‐2K or H-2D regions of the major histocompatibility complex were studied in a cell‐mediated lympholysis assay (CML); all combinations were positive; however, six were unidirectional.

This work uses a physiologically inspired pulse-coupled neural network to find salient regions in an underlying image, and by subsequently introducing a motif function into the genetic programming system, is able to augment the paradigm to introduce thematic image regions.

This commentary starts by looking at those very rare children with either a complete inability to sense pain, or who suffer intermittent severe pain, who usually have Mendelian single gene disorders.

This work surveyed and classified existing literature related to different techniques used by GP research community to deal with the issue of bloat, and combined two methods: double tournament and Tarpeian method to avoid bloated solutions and found that the results were improved with this combination of two methods.

High heritability coupled with high genetic advance was observed for flag leaf area, grain yield panicle-1, grain yielding plant-1 and secondary branches panicle -1 indicating that the expression of these characters is under the control of predominant additive gene actions and hence selection would be effective.

It is demonstrated that there is a marked difference in the survival function according to the formula assuming no familial effect and the empirical survival function estimated from the data; thus, indicating a strong familial component.

The algorithmic workflow is presented and the new algorithm is applied to automatically generate tests with the question database of the undergraduate English course at Zibo Vocational College to alleviate the problem of premature convergence significantly.

A new method of milling tool path generation for the shortest and least directional change based on a new algorithm similar to the Partially Mapped Crossover method in Genetic Algorithm is presented.

Already identified genes are described, which are a causative factor of idiopathic generalized epilepsies, and further prospects of using molecular genetic studies are discussed.

Findings from this thesis suggest that genetic susceptibility of childhood adiposity already has an effect in the early stages of life, and epigenetic mechanisms may play a role in mediating associations of intrauterine exposures and Childhood adiposity outcomes, but need further investigation.

The earlier Scarf and Newton Algorithm for CGE and typical algorithm in current model solution software tools as GAMS and GEMPACK are discussed, with strong and weak points.

It is suggested that the contrasting HLA findings between PGCE and partial epilepsy may reflect underlying differences in the etiology of these disorders.

The investigation of the relationship of loss of function variants in lipoprotein-associated phospholipase A2 and cardiovascular risk in more than 300,000 individuals concluded that Lp-PLA2 is unlikely to be a causal risk factor for atherosclerosis and questioned whether chemical inhibition would be a viable anti-atherosclerotic strategy.

A novel generalized quasi-likelihood score (GQLS) test that is suitable for a study with either a quantitative trait or a binary trait is presented and a logistic regression model is used to link the phenotypic value of the trait to the distribution of allelic frequencies.

The mapping of the genome is ``the end of the beginning'' of a much more detailed understanding of the epilepsies and psychiatric disorders and the analysis of single nucleotide polymorphisms will be useful in optimizing drug treatment with respect to ef®cacy and side effects.

These new mouse models are providing additional insights into aging processes and will be useful for developing intervention strategies and collaborative interactions.

Suggestive evidence indicates that galactosemia is a simple, recessively inherited abnormality; however, the genetics of this condition have not been studied.

It is shown that it is possible to form a symbiosis between a directed specialization and a genetic generalization mechanism achieving a learning mechanism that evolves a complete, accurate, and compact description of a perceived environment.