Top Research Papers on Hair Growth

This review seeks to comprehensively describe the hair cycle, anagen and telogen balance, factors that promote anagen to telogen transition and vice versa, and the clinical utility of a variety of lab testing and evaluations.

The structure, development, cycle and molecular regulation of hair follicles are reviewed in order to provide new ideas for solving diseases and forming functional hair follicle.

This review presents a molecular framework for how phytohormones regulate normal root hair development and how this is affected by changes in the rhizosphere, to enable greater understanding of the specialized functions of root hairs and their developmental and environmental plasticity.

This work uses single-cell RNA sequencing and single-molecule RNA FISH to provide a systematic molecular atlas of full-thickness skin, determining gene expression profiles and spatial locations that define 56 cell types and states during hair growth and rest.

This review discusses emerging paradigms of molecular signaling governing the dermal papilla-epithelial cellular interactions during hair growth and maintenance and the recent progress made towards tissue engineering of human hair follicles.

In Arabidopsis thaliana, the extracellular peptide RALF1 and its receptor, the FERONIA receptor kinase, promote root hair tip growth by modulating protein synthesis by promoting phosphorylation of eIF4E1 and regulating cell expansion in these growing polar cells.

This review includes results from many analyses and provides a comprehensive up-to-date understanding of the subject of the effects of hormonal changes on the hair follicle.

This review will also describe which scalp conditions are amenable to surgery and which are not, and guidelines are provided to help dermatologists better define good or bad candidates for hair transplantation.

It is emphasized that human greying invariably begins with the gradual decline in melanogenesis, including reduced tyrosinase activity, defective melanosome transfer and apoptosis of HFPU melanocytes, and is thus a primary event of the anagen hair bulb, not the bulge.

This work categorizes niche cells into 3 functional modules, including signaling, sensing and message-relaying, and describes the functions and pathological changes of the HFSC niche, which can provide new insight for the treatment of hair loss.

Across four studies, we demonstrate a bias against Black women with natural hairstyles in job recruitment. In Study 1, participants evaluated profiles of Black and White female job applicants across a variety of hairstyles. We found that Black women with natural hairstyles were perceived to be less professional, less competent, and less likely to be recommended for a job interview than Black women with straightened hairstyles and White women with either curly or straight hairstyles. We replicated these findings in a controlled experiment in Study 2. In Study 3A and 3B, we found Black women wit...

Key concepts behind immune-mediated hair regeneration are summarized, gaps in the literature are highlighted and the therapeutic potential of exploiting this relationship for treating various immune- mediated alopecias is discussed.

How the human HF may manage its microbiome via the regulated production of antimicrobial peptides by HF keratinocytes is explored, how the microbiome may impact on cytokine and chemokine release from the HF, and whether the microbiome affects hair growth in turn is explored.

Thanks to the release of the extraordinary EHT image of shadow attributed to\nthe M87* supermassive black hole (SMBH), we have a novel window to assess the\nvalidity of fundamental physics in the strong-field regime. Motivated by this,\nwe consider Johannsen \\& Psaltis metric parameterized by mass, spin, and an\nadditional dimensionless hair parameter $\\epsilon$. This parametric framework\nin the high rotation regimes provides a well-behaved bed to the strong-gravity\ntest of the no-hair theorem (NHT) using the EHT data. Incorporating the\n$\\epsilon$ into the standard Kerr spacetime enr...

The findings suggested that HCC can be considered as a biomarker of PB (though with caution, as 36.1 % of the parents in PB had HCC values equal to or below the mean of the control parents) and reinforce the view that H CC is a biomarkers of chronic stress conditions.

The ‘telescope model’ is described, a generalized model for the development of ectodermal organs in which 2D concentric zones in the placode telescope out to form 3D longitudinally aligned cylindrical compartments.

Given that hair formation and cycling rely on tightly coordinated epithelial–mesenchymal interactions, it is concluded that current bioengineering strategies for HF regeneration with functional restoration are inadequate.

The spacetime structure near nonextremal horizons in any spacetime dimension greater than two is explored and a wealth of novel results are discovered, including the first explicit near horizon realization of the Bondi-Metzner-Sachs algebra.

The proposed formulation of keratin-clay tubule nanocomposite represents a promising strategy for a sustainable medical coating on the hair, which remediates UV irradiation stress.

Searching for violations of the no-hair theorem (NHT) is a powerful way to test gravity, and more generally fundamental physics, particularly with regards to the existence of additional scalar fields. The first observation of a black hole (BH) shadow by the Event Horizon Telescope (EHT) has opened a new direct window onto tests of gravity in the strong-field regime, including probes of violations of the NHT. We consider two scenarios described by the Einstein-Maxwell equations of General Relativity and electromagnetism, to which we add a scalar field. In the first case we consider a minimally-...

Validating the black-hole no-hair theorem with gravitational-wave\nobservations of compact binary coalescences provides a compelling argument that\nthe remnant object is indeed a black hole as described by the general theory of\nrelativity. This requires performing a spectroscopic analysis of the\npost-merger signal and resolving the frequencies of either different angular\nmodes or overtones (of the same angular mode). For a nearly-equal mass binary\nblack-hole system, only the dominant angular mode ($l=m=2$) is sufficiently\nexcited and the overtones are instrumental to perform this test. He...

The first step is to obtain a good history and physical examination, and a prompt diagnosis is very important for the prognosis, while trichoscopy is fundamental for all hair diseases.

The structural and functional data suggest that prestin adopts a unique and complex set of states, tunable by the identity of bound anions (Cl− or SO42−), and how structural rearrangements in the voltage sensor are coupled to conformational transitions at the protein–membrane interface, suggesting a previously undescribed mechanism of area expansion.

The results indicate that exosomes are a previously undescribed mechanism of intercellular communication in the inner ear that can mediate non-autonomous hair cell survival and may represent a novel class of nano-carriers for delivery of therapeutics against hearing loss.

Oral minoxidil was found to be an effective and well-tolerated treatment alternative for healthy patients having difficulty with topical formulations and will be needed to clarify the best treatment protocol.

A key goal for effective AA management is the re‐establishment of a functional HF IP, which will also provide superior protection from disease relapse, and may confer increased susceptibility to AA for some individuals.

It is proposed that it is the adaptation to hot environments and not the type of coat (wool/hair) itself that determines the capacity of the resistance of the animal to HS, due to modifications in essential pathways such as energy metabolism, physiological responses and body size.

The amounts and their associations define the properties of these compositions with interest for hair cosmetic use, such as antioxidant, inflammatory, and antimicrobial activities.

A mini-review sheds light on the role of Wnt/β-catenin in promoting hair growth and the current progress in designing hair loss therapies by targeting this signaling pathway.

It is reported that obesity-induced stress, such as that induced by a high-fat diet (HFD), targets HFSCs to accelerate hair thinning and suggests the importance of daily prevention of organ dysfunction.

This work identifies corticosterone as a systemic inhibitor of HFSC activity through its effect on the niche, and demonstrates that the removal of such inhibition drives HFSCs into frequent regeneration cycles, with no observable defects in the long-term.

It is demonstrated that nearly complete skin can self-assemble in vitro and be used to reconstitute skin in vivo, and that the skin organoids generated in vitro from human pluripotent stem cells are equivalent to the facial skin of human fetuses in the second trimester of development.

The data indicate that the PI3K-Akt signaling pathway plays a crucial role in de novo hair follicle regeneration, and the finding may suggest potential therapeutic applications in enhancing hair regeneration.

3D printed scaffolds provide a suitable microenvironment for DPCs to regenerate entire HFs and could make a significant contribution in the medical management of hair loss and may also have broader applications in skin tissue (and appendage) engineering.

It is shown that cutimycin inhibited the growth of Staphylococcus in human skin hair follicles, helping to shape the composition of the hair follicle microbiota, and contributed to the ecology of the skinhair follicles microbiota.

The results reveal a reciprocal interdependence between a regenerative tissue and its niche at different stages and demonstrate sympathetic nerves can modulate stem cells through synapse-like connections and neurotransmitters to couple tissue production with demands.

TMIE is a subunit of the cochlear mechanotransduction channel and that channel function is regulated by a phospholipid-sensing domain in TMIE with similarity to those in other mechanically gated ion channels.

The potential mechanisms underlying the therapeutic targets involved in pathways associated with the treatment of hair loss and other disorders of skin and hair, including alopecia, skin cancer, skin inflammation, and skin wound healing are highlighted.

Thermoregulating textiles (or protective clothing) are highly demanded for both human health and labor productivity especially in hot working environments. It is challenging to balance wearability and thermal insulating property as they usually demand for opposite porosity. Here, learning from the porous structure of polar bear hair, we report a polyimide aerogel fiber obtained by a freeze-spinning technique. A textile woven with such polyimide fiber is thermally insulating, strong and highly stretchable, fire-retardant (or self-extinguishing), and temperature-resistant. Additionally, it can b...

LDOM has a good safety profile as a treatment for hair loss and systemic adverse effects were infrequent and only 1.7% of patients stopped the treatment due to adverse effects.