Top Research Papers on Hypertension

Evidence is still waiting for evidence from randomized clinical trials to prove that out-of-office BP monitoring is superior to office BP in adjusting antihypertensive drug treatment and in the prevention of cardiovascular complications.

In older patients with hypertension, intensive treatment with a systolic blood-pressure target of 110 to less than 130 mm Hg resulted in a lower incidence of cardiovascular events than standard treatment withA target of 130 to less less than 150mm Hg.

HSIH could be transferred by fecal microbiota transplantation, indicating the pivotal roles of intestinal flora in hSIH development, and a novel mechanism different from inflammation/immunity by which intestinal flora regulated BP is revealed.

A step-wedged cluster randomized trial demonstrates population-wide reductions in blood pressure, which appear to be higher in individuals with hypertension, as well as reductions in risk of hypertension by around 50% for those without hypertension at baseline, after community-wide replacement of regular salt with a potassium-enriched alternative.

The blood pressure response of 48 hypertensive persons and 32 normotensive persons to elemental calcium (as the carbonate or citrate salt), 1000 mg/d for 8 weeks, was assessed in a random fashion.

For adults with prehypertension to established hypertension, high‐quality evidence indicated that the Dietary Approach to Stop Hypertension (DASH) was superior to usual care and all other nonpharmacologic interventions in lowering systolic BP.

Cuffless BP devices have considerable potential for changing the diagnosis and management of hypertension, however, fundamental questions regarding their accuracy, performance, and implementation need to be carefully addressed before they can be recommended for clinical use.

A 12-week aerobic exercise program reduced 24-hour and daytime ambulatory BP as well as office systolic BP in patients with resistant hypertension, providing clinicians with evidence to embrace moderate-intensity aerobic exercise as a standard coadjutant therapy targeting this patient population.

It is suggested that from 1999-2002 to 2015-2018, mean systolic blood pressure decreased among adolescents aged 13 to 17 years and mean DBP decreased among children and adolescents aged 8 to 12 and 13 to 13 years, respectively, in the US.

Time in systolic blood pressure target range independently predicts major adverse cardiovascular event risk, and participants with greater time in target range were younger, had lower 10-year cardiovascular risk and lower baseline systolics blood pressure.

Population-level measures, such as increasing the availability and affordability of fresh fruits and vegetables and lowering the sodium content of packaged and prepared foods, can lower blood pressure in the entire population.

The barriers and opportunities associated with racial and ethnic disparities in blood pressure (BP) control are characterized along with the unique genetic, social, economic, and cultural diversity within these groups that contribute to ongoing BP management inequalities.

This narrative review focused on recent reports on hypertensive disorders of pregnancy, including those related to blood pressure measurement and classification, as well as guidelines for the use of antihypertensive drugs.

It is reported that most countries failed to show sufficient improvements in BP control rates over the past three decades, with greater improvements mainly seen in some high-income countries, also reflected in substantial reductions in the burden of cardiovascular disease and deaths.

High blood pressure is a leading modifiable cause of premature death and one of WHO's global targets for the prevention of non-communicable diseases. Monitoring high blood pressure globally while understanding what is happening at a country level is important to identify tangible and customised solutions for local, national, and global polices to address high blood pressure. As reported in The Lancet by the NCD Risk Factor Collaboration (NCD-RisC), 1 NCD Risk Factor Collaboration (NCD-RisC)Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a po...

In this randomized clinical trial of 297 adults with uncontrolled hypertension, participants randomized to a smartphone coaching app did not have lower blood pressure at 6 months compared with those receiving a blood pressure tracking app.

Whether BP control among US adults with hypertension changed from 1999-2000 through 2017-2018 was determined to be a cross-sectional analysis of National Health and Nutrition Examination Survey data, weighted to be representative of US adults.

The use of machine learning techniques in medicine has increased in recent years due to a rise in publicly available datasets. These techniques have been applied in high blood pressure studies following two approaches: hypertension stage classification based on clinical data and blood pressure estimation based on related physiological signals. This paper presents a literature review on such studies. We aimed to identify the best practices, challenges, and opportunities in developing machine learning models to detect hypertension or estimate blood pressure using clinical data and physiological ...

This exhibition aims to provide a platform for future generations of filmmakers to develop and exhibit their visions of the future through the medium of photography.

This Consensus Statement by the European Society of Hypertension Working Group on BP Monitoring and Cardiovascular Variability provides a review of the evidence on the seasonal BP variation regarding its epidemiology, pathophysiology, relevance, magnitude, and the findings using different measurement methods.

Observational and genetic analyses demonstrate a concordant, positive and potentially causal relationship of lymphocyte count with systolic BP and diastolic BP.

The probiotics LC40 and BFM prevent dysbiosis and the development of endothelial dysfunction and high blood pressure in genetic hypertension and seems to be related to endotoxemia reduction and to increase Treg accumulation in the vasculature.

This update has taken into account new evidence in this field, including a recent statement by the American Heart association, as well as technological developments, which have occurred over the past 20 years.

Hypertensive disorders of pregnancy (HDP) remain one of the major causes of pregnancy-related maternal and fetal morbidity and mortality worldwide. Affected women are also at increased risk for cardiovascular disease later in life, independently of traditional cardiovascular disease risks. Despite the immediate and long-term cardiovascular disease risks, recommendations for diagnosis and treatment of HDP in the United States have changed little, if at all, over past decades, unlike hypertension guidelines for the general population. The reasons for this approach include the question of benefit...

The risk estimates of poor BP control were comparable between patients receiving ARB drugs and those not receiving ARBs, with the only exception of a high risk of heart failure in the non-ARB group.

Recent evidence supports a role for the gut microbiota in hypertension, but whether ambulatory blood pressure is associated with gut microbiota and their metabolites remains unclear. We characterized the function of the gut microbiota, their metabolites and receptors in untreated human hypertensive participants in Australian metropolitan and regional areas. Ambulatory blood pressure, fecal microbiome predicted from 16S rRNA gene sequencing, plasma and fecal metabolites called short-chain fatty acid, and expression of their receptors were analyzed in 70 untreated and otherwise healthy participa...

The adoption of the DASH diet was accompanied by significant BP reduction in adults with and without hypertension, although higher daily sodium intake and younger age enhanced the BP-lowering effect of the intervention.

Weighted estimates for prevalence of IDH in US adults and prevalence of US adults recommended BP pharmacotherapy by the 2017 ACC/AHA guideline based solely on the presence ofIDH are presented.

Aerobic exercise is an effective coadjuvant treatment for reducing ABP in medicated patients with hypertension based on evidence from randomized controlled trials.

There is substantial concordance in the recommendations provided by the 2 guideline-writing committees, with greater congruity between them than their predecessors.

Intraoperative hypotension is common during noncardiac surgery and associated with myocardial injury, acute kidney injury, and death, and largely missed by conventional monitoring.

This review describes the principles of conventional BP measurement, outstanding hypertension/hypotension problems that could be addressed with cuffless methods, and recent technological advances, including smartphone proliferation and wearable sensing, that are driving the field.

The acute effects of different doses of alcohol over time on blood pressure and heart rate in an adult population of healthy and hypertensive adults over 18 years of age were quantified to determine short-term dose-related effects of alcohol versus placebo.

Little robust evidence exists regarding the optimal blood pressure target for patients with heart failure, but a value near 130/80 mmHg seems to be adequate according to the current guidelines.

The information provided by this paper should contribute to a better standardization of future studies on BPV, but should also provide clinicians with some indications on how BPV can be managed based on currently available data.

The information presented includes basic concepts on the role of ET-1 in the pathogenesis of HTN without going into detailed analyses, which allows it to be used by a wide range of specialists for better understanding.

BACKGROUND: The effect of vitamin D supplementation on blood pressure has been explored in previous meta-analyses, but whether the association is causal in the general population is still unknown. We evaluated the association comprehensively and quantitatively. METHODS: We searched PubMed and Embase for relevant cohort studies and randomized controlled trials (RCTs). We used a 2-step generalized least-squares method to assess the dose–response association of circulating 25-hydroxyvitamin D (25[OH]D) and hypertension and a fixed-effects model to pool the weighted mean differences (WMDs) and cor...

Mendelian randomization analysis using data from UK Biobank, Million Veterans Program and genome-wide association study consortia and meta-analysis of randomized controlled trials support an effect of higher serum urate on increasing blood pressure, which may mediate a consequent effect on cardiovascular disease risk.

Clinicians treating depressive patients should carefully consider their blood pressure status and cardiovascular comorbidities because of the effects of antidepressant drugs on blood pressure profiles and potential interactions with antihypertensive treatments.

Dietary sodium reduction significantly lowered BP in the majority of middle-aged to elderly adults, and the decline in BP from a high- to low-sodium diet was independent of hypertension status and antihypertensive medication use, was generally consistent across subgroups, and did not result in excess adverse events.