Top Research Papers on Molecular Biology

A survey of fishes from the Saint Peter and Saint Paul Archipelago was barcoded using the COI marker, which allowed the identification of 21 species, paving the way to further investigate the fish biodiversity of the archipelago, transitioning from barcoding to metabarcoding analysis.

The factors involved in the emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic are discussed, indicating what can be learned from this public health emergency, and what can be applied to the Brazilian scenario.

It is shown that niclosamide at sub-micromolar concentrations inhibits proliferation and migration, and induces apoptosis in both parental and chemo-resistant osteosarcoma cells, with much less toxicity in normal osteoblastic cells.

Its mechanism of control and the stressors which activate it, the diversity of regulated genes in different species, its role in mutagenesis and evolution including the development of antimicrobial resistance, and its relationship with mobile genetic elements are focused on.

This review of current and ongoing studies on bat evolution highlights key aspects of studies that have used bats as a model for morphological adaptations, diversification during adaptive radiations, and morphological novelty and investigates morphological specialization by reviewing current knowledge about wing and face evolution.

The role of the tick’s salivary glands in secreting a remarkably complex array of anti-hemostatic molecules that modulate the bite site in the host skin and how these salivARY molecules facilitate the lengthy blood-sucking process is highlighted.

Downregulated miR-181b serves as a diagnosis and prognosis biomarker for SCAP, which may be useful biological information for the early detection and risk estimation of SCAP.

This article has focused on molecules that are produced by osteoblasts, osteocytes, and osteoclasts and their mechanism of action on these cells and their mechanisms of action target different molecular aspects of these bone cells to minimize osteoporosis.

The diagnostic challenges, molecular biology and genetics of malignant melanoma, as well as the current therapeutic options for patients with this diagnosis are presented.

This work discusses how quantum computation may advance the practical usefulness of the quantum foundations of molecular biology by offering computational advantages for simulations of biomolecules and considers the dominating classical problems as well as data‐driven approaches of bioinformatics and the degree to which they might become amenable to quantum simulation and quantum computation.

SUMMARY Acidocalcisomes are organelles conserved during evolution and closely related to the so-called volutin granules of bacteria and archaea, to the acidocalcisome-like vacuoles of yeasts, and to the lysosome-related organelles of animal species. All these organelles have in common their acidity and high content of polyphosphate and calcium. They are characterized by a variety of functions from storage of phosphorus and calcium to roles in Ca2+ signaling, osmoregulation, blood coagulation, and inflammation. They interact with other organelles through membrane contact sites or by fusion, and...

Hypotheses about the origin and early evolution of the genetic code are reviewed, showing that populations of open biological systems named progenotes were capable of accumulating and exchanging genetic material, producing the first genomes.

The data suggest variants in the 3'UTR of BTD do not explain the genotype–phenotype discrepancies found in Brazilian individuals with reduced biotinidase, and miRNAs and regulatory elements found in the region may present relevance in understanding the genotypes-phenotype association.

Quasispecies coronavirus evolution in spillovers follows the virus life cycle, starting with the evolution of the receptor binding proteins, followed by the replicase and then proteins involved in virion assembly, keeping the general fitness of the mutant spectrum stable.

Review of available evidence does not at present favor the idea that WGS analyses are sufficiently developed to allow reliable predictions of the risk components for monogenic and polygenic hereditary diseases in healthy individuals, and it is still better for WGS to remain reserved for the diagnosis of pathogenic variants of Mendelian diseases.

The label-free quantification-mass spectrometry and bioinformatics approaches were applied and revealed an interesting set of proteins, which were mainly involved in cancer biology, which provide a relevant data source for the MBC research that can help the therapeutic strategies for its management.

Pseudocercospora ulei is the causal agent of South American Leaf Blight, the main disease affecting Hevea brasiliensis rubber tree, a native species to the Amazon, and has the largest genome size among Mycosphaerellaceae, with the highest TE content.

Plant biologists have begun to unravel the molecular mechanisms behind grafting, yielding insights into plant evolution and expanding the scope of this technique.

The results of the present study indicated karyotypic differences in comparison with the other populations of H. multifasciatus studied previously, reinforcing the need for further research to identify isolated populations or the potential existence of cryptic Hollandichthys species.

Causing variants of classes I and II, which are related to a major severity of the illness, were identified in 135 of 184 alleles and more than 2/3 of the patients were candidates for the use of CFTR modulators therapy.

It is shown that the frequency of red blood cell polymorphisms in two Native American groups is very different from that of blood donors, when it is evaluated blood groups different from ABO and Rh systems, suggesting that a better ethnic characterization of blood unit receptors is necessary.

The long term goal of the research is to elucidate the molecular mechanisms by which proteins are targeted to specific and distinct compartments in membrane traffic.

It is shown that PMD should be regarded as a distinct disease entity, that requires tailored treatment strategies, and the critical role of the peritoneal immune system is discussed.

Molecular biologists must reincorporate ideas from classical biochemistry and absorb modern concepts from molecular evolution, to craft a new lens through which they can evaluate the functionality of transcriptional units, and make sense of the authors' messy, intricate, and complicated genome.

This review examines extant research on the metastatic cascade of BM through the molecular events that create and sustain BM to reveal clues that can assist the development of effective targeted therapies that treat established BMs and prevent BM recurrence.

An overview of the molecular foundation and classification of childhood leukemias is provided, focusing on recent scientific advances, and potential therapeutic implications are discussed.

The latest findings on genetic abnormalities, with the presentation of the molecular pathology of vascular anomalies, are summarized.

The great efficacy and productivity of the reductionist approach of preand post-genomic Molecular Biology has yielded an overwhelming accumulation of detailed biological data at molecular level, leading to an accumulation of new data at higher rates than those required for their processing to transform these data in new information and finally in actual new knowledge.

Activity and safety of cabozantinib in osteosarcoma were studied, as well as sorafenib and pazopanib, and novel bifunctional molecules, of potential imaging and osteosARcoma targeting applications may be used in the future.

Ch Chromosome-level assembly of the ancient tetraploid genome of miscanthus chromosomes is reported to provide resources that can link its chromosomes to related diploid sorghum and complex polyploid sugarcane.

Urothelial carcinoma has distinctive molecular pathways involved in sustained proliferative signaling, evasion of growth suppressors, resistance to cell death, promotion of replicative immortality, induction of angiogenesis, activation of invasion and metastasis, genome instability and mutation, tumor-promoting inflammation, reprogramming of energy metabolism, and evasion of immune destruction.

This work considers anomalous transport in the context of microrheology and the heterogeneous viscoelasticity of complex fluids and HAT in the wavefronts of reaction–diffusion systems is considered since it plays an important role in morphogenesis and signalling.

It is argued that, even at the very low level of biological complexity represented by the structures and functions of individual proteins, the predictive capacity of molecular biology remains too weak to form a reliable basis for industrial research strategy, even when coupled with almost unlimited computing power.

Some of the most important aspects of the use of archaea as a model system for genetic evolution, the development of genetic tools, and their application for the elucidation of the basal molecular mechanisms in this domain of life are reported.

Enzymes and genes are described, whose control minimizes the rate of production of entropy and could explain selective pressures in biological evolution and the rapid proliferation of cancer cells.

This guide will provide resources to students majoring and/or taking classes in Biochemistry & Molecular Biology within the Department of Biology and Earth Science and theDepartment of Chemistry.

The Origin of Species provided a theoretical framework necessary to nudge biology from natural history to scientific discipline, and since Darwin biology seems to have undergone a spiraling fragmentation, a splintering that appears especially acute during the later decades of this century.

A synthesis of the lyophilization process is presented, describing the events of each step of the procedure, and providing general information about the technique, to preserve and prolong the useful life of the reaction components, in cases of temperature variation.

Glioblastoma (GBM, grade IV astrocytoma), the most frequently occurring primary brain tumor, presents unique challenges to therapy due to its location, aggressive biological behavior, and diffuse infiltrative growth, thus contributing to having disproportionately high morbidity and mortality.

This chapter aims to molecular biology techniques and concepts in the study, development and production of various compounds of industrial pharmaceutical interest, to better understand this cascade of events that might influence the druggability of therapeutic targets.

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Recent progress in the study of ToV molecular biology including reverse genetics is reviewed, focusing on the similarities and differences between ToVs and CoVs.

A guide to resources on the history of molecular biology and biotechnology, including thehistory of the Human Genome Project (HGP).

The textbook presents the main range of issues in molecular biology — the most rapidly developing area of biological science, and will be useful for teachers of biology and chemistry of high school.

An overview of recent advances in the understanding of the interplay of the genetic, epigenetic, and transcriptomic landscape in the development of midgut NENs is provided, a topic that is critical to understanding their biology and improving treatment options and outcomes for patients.

Molecular biology: different facets , Molecular biology: different facets , کتابخانه‌های دانشگاه کردستان

This work aims to summarize the main features, milestones, and results provided by the application of FFF in the field of molecular biology and biotechnology, with a focus on the years from 2000 to 2022.

Current insights on disparities in the replication of pathogenic human retroviruses are examined, with a particular focus on the determinants of structural and genetic diversity amongst HIVs and HTLV.

Homocysteine is a non-proteinogenic sulfhydryl-containing amino acid derived from methionine and is a homologue of cysteine [...].

A comprehensive review of existing studies is performed and discussed how etiology, genetics and epigenetic characteristics, together with the tumor microenvironment, contribute to the malignant behavior and dismal prognosis of EAC.