Top Research Papers on Nanoparticles

This review explores and highlights the current state of nanotoxicology research with a focus on mechanistic understanding of nanoparticle toxicity at organ, tissue, cell, and biomolecular levels, and discusses nanotoxicity mechanisms, including generation of reactive oxygen species, nanoparticle disintegration, modulation of cell signaling pathways, and protein corona formation.

The research possibilities for these three lignocellulosic-derived nanoparticles are still wide and there is potential in drug delivery applications, especially for enhancing their characteristics with further surface modifications adjusted to the drugs.

This review discusses viral mechanisms of entry into host cells and then details the major and important types of nanomaterials that could be used as antiviral agents, including silver, gold, quantum dots, organic nanoparticles, liposomes, dendrimers and polymers.

It is hypothesized that robust quantitative assessment of whole-body pharmacokinetics of nanoparticles and development of mathematical models that can predict their disposition can improve the probability of successful clinical translation of these modalities.

A bibliographic review of the genotoxicity studies carried out with silver nanoparticles over the last six years showed that AgNPs produce genotoxic effects at all DNA damage levels evaluated, in both in vitro and in vivo assays.

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTIntroduction: Nanoparticles in CatalysisDidier AstrucDidier AstrucISM, UMR CNRS 5255, University of BordeauxMore by Didier AstrucView Biographyhttp://orcid.org/0000-0001-6446-8751Cite this: Chem. Rev. 2020, 120, 2, 461–463Publication Date (Web):January 22, 2020Publication History Published online22 January 2020Published inissue 22 January 2020https://pubs.acs.org/doi/10.1021/acs.chemrev.8b00696https://doi.org/10.1021/acs.chemrev.8b00696editorialACS PublicationsCopyright © 2020 American Chemical Society. This publication is available under these Terms o...

In this fast-pacing world of science and technology, nanotechnology is making its presence felt in everyday life.This multidisciplinary science is filling the gap and bridging all the major branches of science and providing a common platform for scientists and technologists.As a result, new innovative nanoproducts are being developed making our lives all the more easier.Synthesis and Applications of Nanomaterials provides a comprehensive introduction to nanomaterials, their properties, processing techniques, and applications.This book covers the basics of nanotechnology and provides a solid un...

The different nanolignin preparation methods are summarized, emphasizing anti-solvent precipitation, self-assembly and interfacial crosslinking, and advances in numerous potential high-value applications, such as use in food packaging, biomedical, chemical engineering and biorefineries are described.

Alkylcyanoacrylates can be polymerized in acidified aqueous media by a process of anionic polymerization. The small particles produced tend to be monodisperse and have sizes in the range of 20 to 3000 nm depending upon the polymerization conditions and the presence of additives in the form of surfactants and other stabilizers. The polyalkylcyanoacrylate nanoparticles so produced have been studied in recent years as a possible means of targeting drugs to specific sites in the body, with particular emphasis in cancer chemotherapy. The small colloidal carriers are biodegradable and drug substance...

This study produces Co3O4 nanoparticles (NPs) using ultrasonic wave grinding technology. The experimental results show that the average diameter of Co3O4-NPs is about 6 nm. Au nanoparticles are adsorbed onto the surface of Co3O4-NPs and integrated with a MEMS structure to form a Au/Co3O4-NPs/MEMS NO2 gas sensor. The diameter of Au nanoparticle is approximately 1 nm. For a 100-ppb NO2 gas concentration, an Au/Co3O4-NPs/MEMS gas sensor has the greatest sensor response and has a higher sensitivity to NO2 than other gases (SO2, NH3, CO, CO2) when NO2 gas is introduced at 10 ppm and at the optimal ...

In this study, the food-grade gelatin nanoparticles prepared by genipin cross-linking were applied to stabilize Pickering emulsion and showed that increasing GNPs concentration could obviously increase the π value of GNPs, thus enhancing GNPs adsorption at the oil-water interface and the formation of network structure (CLSM), consequently resulting in a smaller droplet size and FI of the PickeringEmulsion.

The synthesized FeONPs were screened for their cytotoxic activity on PBMCs using MTT assay and found to exhibit good biocompatibility, and the GS FeONP exhibited potential antibacterial activities and meanwhile showed less toxicity in brine shrimp lethality assay.

The state-of-the art of biosorption technology applying magnetically immobilized cells is presented in this review and provides insights into this research area.

This review provides a synthetic overview of the recent research advancements addressing the topic of catalysis with colloidal ruthenium metal nanoparticles through the last five years to enlighten the interest of rutenium metal at the nanoscale for a selection of catalytic reactions performed in solution condition.

Cuprous oxide (Cu2O) nanoparticles are synthesized by aqueous precipitation method for the production of low-cost conductive ink, which is suitable for a printed, electronic application. The major drawback of copper ink, such as rapid oxidation overcomes by the formation of Cu2O ink. Structural characterizations reveal that spherical, nano-sized, polycrystalline cubic structure of Cu2O nanoparticles synthesized in the present work. The studies on transmission electron microscopies show that the size of these nanoparticles is approximately 7.5 ± 1.8 nm. The Cu2O nanoparticles show an absorption...

The development and application of trimetallic nanoparticles continues to accelerate rapidly as a result of advances in materials design, synthetic control, and reaction characterization. Following the technological successes of multicomponent materials in automotive exhausts and photovoltaics, synergistic effects are now accessible through the careful preparation of multielement particles, presenting exciting opportunities in the field of catalysis. In this review, we explore the methods currently used in the design, synthesis, analysis, and application of trimetallic nanoparticles across bot...

An overview of copper nanoparticles and their applications in dentistry is provided to enhance the physical and chemical properties of various dental materials, such as dental amalgam, restorative cements, adhesives, resins, endodontic-irrigation solutions, obturation materials, dental implants, and orthodontics archwires and brackets.

The field of nanotechnology has grown over the last two decades and made the transition from the benchtop to applied technologies. Nanoscale-sized particles, or nanoparticles, have emerged as promising tools with broad applications in drug delivery, diagnostics, cosmetics and several other biological and non-biological areas. These advances lead to questions about nanoparticle safety. Despite considerable efforts to understand the toxicity and safety of these nanoparticles, many of these questions are not yet fully answered. Nevertheless, these efforts have identified several approaches to min...

A blueprint that involves the use of artificial intelligence-powered nanoparticles in cancer treatment applications is proposed, aiming to usher in a new era of precise and personalized cancer therapy, providing patients with individualized treatment options.

Different from organic dyes and semiconductor quantum dots that generally produce downshifting luminescence, upconversion nanoparticles (UCNPs) are a class of optical transducers that convert long-wavelength excitation to shorter-wavelength emission by taking advantage of long-lived intermediate energy states of lanthanide ions. A good number of strategies have become available to enhance optical emission in UCNPs, which has largely expanded the scope of upconversion research. UCNPs with intense and tunable emissions have enabled many advanced applications such as upconversion lasing, super-re...

This review will meticulously explore the current performance of polymeric nanoparticles against a myriad of diseases including cancer, viral and bacterial infections, before finally evaluating the advantages and crucial challenges that will determine their wider clinical potential in the decades to come.

This review provides a comprehensive summary of the recent progress in the synthesis and catalytic properties of the encapsulated metal nanoparticles, including their encapsulation in nanoshells of inorganic oxides and carbon, porous materials, and organic capsules.

A critical review of recent progress in microfluidic NPs for drug delivery with a focus on the synthesis of organic NPs usingmicrofluidics and their applications in making popular and clinically relevant NPs.

The high stability, controlled drug release makes nanoparticles the most suitable drug delivery system and they are suitable candidates for various marketable and local applications, which include imaging, catalysis medical applications and environmental applications.

This work focuses on Microencapsulation of Living Cells and Tissues, and on recent Advances in Artificial Cells with Emphasis on Biotechnological Approaches Based on Micro Encapsulation.

This review article surveys microfluidic methods for nanoparticle isolation and enrichment based on their underlying mechanisms, including acoustofluidics, dielectrophoresis, filtration, deterministic lateral displacement, inertial microfluids, optofluids, electrophoreses, and affinity-based methods.

Heterogeneous catalysis is a chemical process achieved at solid–gas or solid–liquid interfaces. Many factors including the particle size, shape and metal-support interfaces can have significant influences on the catalytic properties of metal catalysts. The recent progress in the synthesis techniques and advanced characterization tools allow to understand the catalytic mechanisms at molecular level. In this Review, the size and shape dependent catalytic chemistry of metal nanoparticles and their electronic properties will be discussed. Then the unique catalytic chemistry at the metal-support in...

Current challenges in drug delivery warrant future studies about structure-function correlations, large-scale production, and targeted delivery to realize the full potential of lipid nanoparticles for wider clinical and pharmaceutical applications in future.

Conventional cancer treatments, such as surgical resection, radiotherapy, and chemotherapy, have achieved significant progress in cancer therapy. Nevertheless, some limitations (such as toxic side effects) are still existing for conventional therapies, which motivate efforts toward developing novel theranostic avenues. Owning many merits such as easy surface modification, unique optical properties, and high biocompatibility, gold nanoparticles (AuNPs and GNPs) have been engineered to serve as targeted delivery vehicles, molecular probes, sensors, and so on. Their small size and surface charact...

Current evidence of alterations in cytosine DNA methylation and histone modifications in response to nanomaterials and nanoparticles exposures in vivo and in vitro is summarized.

Lipid nanoparticles have successfully entered the clinic for the delivery of mRNA and lipid nanoparticle–mRNA vaccines are now in clinical use against coronavirus disease 2019 (COVID-19), which marks a milestone for mRNA therapeutics.

The dominant mechanism of nanoparticle entry into solid tumours has now been shown to be an active trans- endothelial pathway rather than the currently established passive transport via inter-endothelial gaps.

Bimetallic nanostructures on graphene, zeolites, clays, fibers, polymers, as well as non-supported bimetallic nanoparticles are reviewed, their synthesis methods and resulting properties are illustrated, along with their antimicrobial activity and potential against different strains of microbes.

Preliminary results indicate the safety, efficacy and viability of silica nanoparticles under clinical scenarios, including oral drug delivery, diagnostics, plasmonic resonance and photothermal ablation therapy.

The current clinical landscape of therapeutic gold nanoconstructs is analyzed, the shared characteristics that allowed for their transition from bench to bedside are discussed, and existing hurdles that need to be overcome before they can be approved for clinical use are examined.

This review aims to establish factors affecting antibacterial and cytotoxic effects of silver nanoparticles, as well as to expose the advantages of using AgNPs as new antibacterial agents in combination with antibiotic, which will reduce the dosage needed and prevent secondary effects associated to both.

Nanozymes are defined as nanomaterials, which possess the intrinsic enzyme-like activities, and thorough understanding of rational regulation and manipulation of the activities of nanozymes through alloying or doping and proper choice of conditions, under which they are used are of great significance.

In this review, we summarize recent advances in mixing-, droplet-, and multiple field-based microfluidic reactors for fabrication of a variety of functional nanoparticles.

The research demonstrated the antimicrobial activity of ZrO2 nanoparticles at different concentrations comparable to standard antibiotics against gram-positive bacteria and gram-negative bacteria (Klebsiella pneumonia), respectively.

The role and importance of animal proteins in Nano medicine and the various benefits of these biomolecules for the preparation of drug delivery carriers and the characteristics of plant protein Nano carriers and protein Nano cages and their potentials in diagnosis and treatment are examined.