Top Research Papers on Novels

Novel immunotherapies and cellular therapies should further improve the prognosis of patients with multiple myeloma and should further improve the prognosis of patients with RR MM.

It is argued that the recognition of the novelty of human‐modified ecosystems logically leads to novel pathways of how wolves can influence ecosystem functioning and that these novel interactions may be the true ecological and societal value of having wolves returning to human‐modified landscapes.

Ecologists, particularly restoration ecologists, were early to recognise the challenges of historically unprecedented combinations of species and abiotic conditions brought about by human intervention. However, to date, this ecological understanding has paid limited attention to sociocultural considerations. We propose the concept of novel natures to combine ecological and social dimensions in the perception and evaluation of novelty in nature, and to assist conservation and restoration decision-making in a time of rapid environmental change.

The latest progress and challenges of multi-omics for designing new treatments for human diseases are summarized, focusing on how to integrate and analyze multiple proteome data and examples of how to use multi-proteomics data to identify new drug targets.

One of the central images conjured up by the gothic novel is that of a shadowy spectre slowly rising from a mysterious abyss. In The Rise of the Gothic Novel, Maggie Kilgour argues that the ghost of the gothic is now resurrected in the critical methodologies which investigate it for the revelation of buried cultural secrets. In this cogent analysis of the rise and fall of the gothic as a popular form, Kilgour juxtaposes the writings of William Godwin with Mary Wollstonecraft, and Ann Radcliffe with Matthew Lewis. She concludes with a close reading of the quintessential gothic novel, Mary Shell...

Beverages have been part of human nutrition for millennia and are still a major source of energy for humans today.

3DiM, a diffusion model for 3D novel view synthesis, is presented, which is able to translate a single input view into consistent and sharp completions across many views, and a new evaluation methodology, 3D consistency scoring, is introduced to measure the3D consistency of a generated object by training a neural field on the model's output views.

This unusual monkeypox outbreak should prompt all clinicians to be attuned to the possibility of this infectious disease and to contact their state or local health department immediately.

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The nanomaterials used to address liver diseases nanozymes, Nano-based oligonucleotide, Lipid-based nanostructures and nanoemulsions and Extracellular Vesicles are first discussed in this study and the ways in which nanomaterials target liver illness are examined.

Because accurate wave functions can be very complex, an important new functionality in GAMESS is the quasi-atomic orbital analysis, an unbiased approach to the understanding of covalent bonds embedded in the wave function.

This work proposes a neural rendering approach: Visually-Guided Acoustic Synthesis (ViGAS) network that learns to synthesize the sound of an arbitrary point in space by analyzing the input audio-visual cues.

The OS tumor microenvironment is reviewed and the promising immunotherapies available in the management of OS are appraised to help overcome the drawbacks of conventional treatments.

This essay examines the phenomenon of typicality as a horizon of the novel's activity. The novel's manner of representing seems to require a certain belief in the existence of types. Yet how the novel goes about demonstrating this belief does not sit easily with usual ideas about what classification looks like or how it proceeds. Novels seem to manifest typicality while pulling away from taxonomic endeavors in the empirical world. If taxonomy aims at systematically arranging things in order to express how they are related to each other, typicality in the novel proceeds differently. Instead o...

Advances in the immunology and pathogenesis of MG have ushered in an era of newer therapies which are more specific and efficacious, and complement inhibitors and neonatal Fc receptor blockers target disease-specific pathogenic mechanisms linked to myasthenia.

A receiver-by-receiver-based imaging algorithm that relaxes the requirement for the sub-block width and is successfully avoided by ghost targets, which are successfully avoided by presented method with the same wide sub-block.

This review provides the most up-to-date survey to the authors' knowledge regarding emerging diagnostic and therapeutic strategies for lung cancer to provide clinicians with a comprehensive reference of the options for treatment available now and those which are soon to come.

The slow decay of probability with epidemic intensity implies that extreme epidemics are relatively likely, a property previously undetected due to short observational records and stationary analysis methods.

The insight gained from clinical use of liposome drug delivery systems can now be integrated to design liposomes that can be targeted on tissues, cells or intracellular compartments with or without expression of target recognition molecules onliposome membranes.

A diffusion-based model for 3D-aware generative novel view synthesis from as few as a single input image that incorporates geometry priors in the form of a 3D feature volume and has the ability to autoregressively synthesize 3D-consistent sequences.

The Twentieth Century NovelAn Introduction to the English Novel: To George EliotThe Modernist NovelThe English NovelTelling ComplexionsThe English Novel in History, 1950-1995Nation and NovelWork in the English NovelElizabeth Singer Rowe and the Development of the English NovelThe English NovelThe Fallen Woman in the Nineteenth-Century English NovelThe Novel in EnglishThe Graphic NovelAn Introduction to the English Novel: Henry James to the present dayLate Modern EnglishThe Cambridge History of the English NovelThe English NovelThe Nineteenth-Century English NovelRisk and the English NovelHabit...

To combat resistant bacteria and to stop the spread of resistant illnesses, regulations and public education regarding the use of antibiotics in hospitals and the agricultural sector should be combined with research and technological advancements.

This ISCA 2016 paper serves as an excellent illustrative example of three out of five directions: emerging memory technology, domain-specific accelerators, and machine learning workloads.

A patient with COG6‐CDG with novel variants and a novel clinical feature namely a congenital recto‐vaginal fistula is described.

A novel gene, Novel Seed Size (NSS), involved in seed development, is identified by analyzing a T-DNA mutant, a random mutant of the GmFTL4pro:GUS transgenic line, with phenotypes with small and brown seed coats.

Many natural disturbances have a strong climate forcing, and concern is rising about how ecosystems will respond to disturbance regimes to which they are not adapted. Novelty can arise either as attributes of the disturbance regime (e.g., frequency, severity, duration) shift beyond their historical ranges of variation or as new disturbance agents not present historically emerge. How much novelty ecological systems can absorb and whether changing disturbance regimes will lead to novel outcomes is determined by the ecological responses of communities, which are also subject to change. Powerful c...

This work proposes LLM2LLM, a targeted and iterative data augmentation strategy that uses a teacher LLM to enhance a small seed dataset by augmenting additional data that can be used for fine-tuning on a specific task.

O artigo faz uma análise da categoria da infância marginalizada na Amazônia paraense por meio das imagens e palavras contidas na graphic novel intitulada Castanha do Pará (2018), de Gidalti Moura Jr., sob o viés metodológico da Literatura Comparada. A narrativa é inspirada no conto Adolescendo solar (2009) e narra o cotidiano da personagem Castanha, um menino descrito com uma cabeça de urubu que vive na feira do Ver-o-Peso nos anos de 1990, na cidade de Belém do Pará.

This review focuses on the breakthroughs in taxifolin for the treatment of diseases from 2019 to 2022 according to various systems of the human body, such as the nervous system, immune system, and digestive system.

With the energy crisis and environmental pollution, the development of sustainable new energy has become an urgent priority. These considerations make society aware that green energy technologies are critical to...

Recent advances in novel diagnostic biomarkers for tumor tissue, blood and stool samples in CRC patients are discussed.

A potential therapeutic strategy in which targeting necroptotic factors may improve the pathological changes and clinical symptoms of neuroinflammatory disorders is shown.

Silicon carbide (SiC) is emerging rapidly in novel photonic applications thanks to its unique photonic properties facilitated by the advances of nanotechnologies such as nanofabrication and nanofilm transfer. This review paper will start with the introduction of exceptional optical properties of silicon carbide. Then, a key structure, i.e., silicon carbide on insulator stack (SiCOI), is discussed which lays solid fundament for tight light confinement and strong light-SiC interaction in high quality factor and low volume optical cavities. As examples, microring resonator, microdisk and photonic...

Endometrial diseases are the most common gynecological pathologies in Western Countries and have become one of the leading causes of cancer in women in Western countries.

It is submitted that the safe operating space of the planetary boundary of novel entities is exceeded since annual production and releases are increasing at a pace that outstrips the global capacity for assessment and monitoring.

HIPK2 regulates several pro-fibrotic pathways such as Wnt/β-catenin, TGF-β and Notch involved in renal, pulmonary, liver and cardiac fibrosis and is highlighted as a promising target for therapeutic purposes in fibrosis.

This paper presents YOLOv8, a novel object detection algorithm that builds upon the advancements of previous iterations, aiming to further enhance performance and robustness, and is poised to address the evolving needs of computer vision systems.

The minimally invasive nature of liquid biopsies, allowing frequent collection, can be used in the monitoring of therapy response in real time, allowing the development of novel approaches in the therapeutic management of cancer patients.

Kehidupan manusia selalu dibayang-bayangi oleh bencana. Diperlukan upaya untuk meminimalisasi dampak bencana, baik yang berupa bencana alam, non-alam, maupun bencana sosial. Karya sastra sebagai karya kreatif (ekspresif) dan cerminan alam (mimetik), menjadi salah satu objek yang layak dikaji untuk memberikan sumbangsih dalam kemitigasian bencana. Penelitian ini menganalisis struktur novel yang mengangkat cerita kebencanaan. Metode yang digunakan dalam penelitian ini adalah penelitian kualitatif dengan pendekatan struktural sebagai alat analisis. Temuan dari analisis intrinsik menunjukkan bahwa...

The editorial highlights the mental health initiative of the Government of Assam, India through the Monon: Assam Cares programme to deal with the coronavirus disease 2019 (COVID-19) pandemic and trained mental health professionals proactively reached to people with COVID- 19 to provide psychological aid.

This review summarizes the available information on the pathophysiological implications of atherosclerosis, focusing on endothelium dysfunction, inflammatory factors, aging, and uric acid, vitamin D, and miRNA expression as recent evidence of interactions of the molecular and cellular elements.

Experimental results on two diverse datasets of real-world scenes validate that the proposed point cloud-based method generates consistent stylized novel view synthesis results against other alternative approaches.

This study introduces the theoretical framework of scenarios engineering (SE) for building accessible and reliable foundation models in metaverse, namely, “SE-enabled foundation modelsInMetaverse,” which comprises a six-layer architecture that creates closed-loop, virtual–real, and human–machine environments that provides the best indices and goals for the foundation models.

2D GaSe is a semiconductor belonging to the group of post‐transition metal chalcogenides with great potential for advanced optoelectronic applications. The weak interlayer interaction in multilayer 2D materials allows the formation of several polymorphs. Here, the first structural observation of a new GaSe polymorph is reported, characterized by a distinct atomic configuration with a centrosymmetric monolayer (D3d point group). The atomic structure of this new GaSe polymorph is determined by aberration‐corrected scanning transmission electron microscopy. Density‐functional theory calculations ...

The role of SIRT1 in endocrine and metabolic diseases such as hyperuricemia, diabetes, hypertension, hyperlipidemia, osteoporosis, and polycystic ovarian syndrome is outlined and the Sirt1 agonists and inhibitors are summarized.

An LLM-based recommender simulator called RecAgent is introduced, which provides new opportunities to overcome the short-comings of simulation-based studies and thus highlight their advantages, such as much more application scenarios and cheaper data acquisition strategies.

Worldwide, a huge amount of agricultural food wastes and byproducts containing valuable bioactive compounds are generated, especially throughout the entire supply chain. Minimizing food wastes and byproducts is the first option to avoid environmental problems, and to help the economy and the society. Although many countries implement policies to reduce food wastes and byproducts, and different management methods are available to utilize agricultural food wastes, they are still produced annually. Nanotechnological and biotechnological approaches are recently used as novel and green applications...

A UNified Objective function (UNO) for discovering novel classes, with the explicit purpose of favoring synergy between supervised and unsupervised learning, and outperforms the state of the art on several benchmarks.

Safety and feasibility of transulnar catheterization when ipsilateral radial access is not available and the randomized comparison of percutaneous transluminal coronary angioplasty by the radial, brachial and femoral approaches is studied.

Current therapies as well as novel targets and therapeutics against malaria are focused on, resulting in more than 10 unique potential anti-malaria drugs added to the pipeline for clinical development.