Top Research Papers on Novels

This paper describes the case of a 6-month-old infant admitted and diagnosed with classic Kawasaki disease, who also screened positive for COVID-19 in the setting of fever and minimal respiratory symptoms, and the indications for CO VID-19 testing in the febrile infant.

This review aims to asses the actual data from recent literature dealing with the novel Coronavirus (nCoV) isolated in the automn of 2019, finding that the collected data became useful for better understanding of virus replication, at description of virion structure as well as by interpretation of Coronvirus properties.

This post forms part of my '[aspects of the novel](/2022/01/04/aspects-of-the-novel/)' collection. Please do note that these entries, which may appear basic, are simply my own notes on the subject. They implicitly or explicitly describe a canon not of my own making or choosing and replicate this from various sources. The original encyclopaedia articles are far more comprehensive, nuanced and worth consulting.

The emergence of a new coronavirus in China raises global alarm and calls for urgent action to stop its spread.

This work addresses new insights into AD epidemiology, biomarkers, endotypes, prevention, and comorbidities, and hopes to broaden physicians' ability to diagnose and manage AD patients, and perhaps find a cure for this chronic condition.

The current state of RNA vaccines, recombinant adenovirus vector-based vaccines, and advances from biomaterials and engineering that address these important public health challenges are discussed.

A potential therapeutic strategy in which targeting necroptotic factors may improve the pathological changes and clinical symptoms of neuroinflammatory disorders is shown.

Comprehensive descriptions on data deposition, management, release and utility in 2019nCoVR are provided, laying important foundations in aid of studies on virus classification and origin, genome variation and evolution, fast detection, drug development and pneumonia precision prevention and therapy.

Propolis and its main flavonoids ingredients should not be overlooked and should be evaluated in clinical trials to better elucidate their potential application in various fields of medicine.

This review focuses on different generation of ethosomes and their comparison with other conventional liposomes.

In the early stages, COVID-19 has spread beyond the nation’s ability to detect it, and the removal of all federal limits on testing left many with questions about what had happened with testing and what should happen next.

The Metaverse is not a radical departure. It is an incremental evolution. Previous virtual worlds, like Second Life, have laid the groundwork for the development of the Metaverse by providing valuable insights into virtual environments and social interactions. Studies of these earlier platforms contribute to a more nuanced understanding of what the Metaverse is, and what it is not. Based on studies of virtual worlds and by applying inductive processes of reflection and abstraction, we propose a framework that supports the identification of attributes that help differentiate the Metaverse from ...

This work is one of the first solutions to produce a comprehensive SDN dataset to verify the performance of intrusion detection systems and the new dataset includes the benign and various attack categories that can occur in the different elements of the SDN platform.

Abstract 2D MBenes, early transition metal borides, are a very recent derivative of ternary or quaternary transition metal boride (MAB) phases and represent a new member in the flatland. Although holding great potential toward various applications, mainly theoretical knowledge about their potential properties is available. Theoretical calculations and preliminary experimental attempts demonstrate their rich chemistry, excellent reactivity, mechanical strength/stability, electrical conductivity, transition properties, and energy harvesting possibility. Compared to MXenes, MBenes’ structure appe...

To combat resistant bacteria and to stop the spread of resistant illnesses, regulations and public education regarding the use of antibiotics in hospitals and the agricultural sector should be combined with research and technological advancements.

Abstract Efferocytosis is a physiologic phagocytic clearance of apoptotic cells, which modulates inflammatory responses and the immune environment and subsequently facilitates immune escape of cancer cells, thus promoting tumor development and progression. Efferocytosis is an equilibrium formed by perfect coordination among “find-me”, “eat-me” and “don’t-eat-me” signals. These signaling pathways not only affect the proliferation, invasion, metastasis, and angiogenesis of tumor cells but also regulate adaptive responses and drug resistance to antitumor therapies. Therefore, efferocytosis-relate...

The performance of mRECIST during the last decade is reviewed, incorporating novel clarifications and refinements in light of emerging challenges in the study and management of HCC.

The timeline of a live forecasting exercise with massive potential implications for planning and decision making is described and objective forecasts for the confirmed cases of COVID-19 are provided.

The evolution of flight in bats seem to have selected for a unique set of antiviral immune responses that control virus propagation, while limiting self-damaging inflammatory responses.

Lignin, a major constituent of lignocellulosic biomass, is the largest natural source of aromatic molecules and thus is an attractive feedstock for renewable chemical production. Direct incorporation of isolated lignin into materials has long been researched due to the idea's simplicity and the scheme's potentially high atom economy. However, due to its high chemical reactivity lignin is difficult to isolate without having it undergo uncontrolled condensation and repolymerization, which greatly hinder its ease of incorporation into polymers and other materials. Therefore, controlled chemical m...

The purpose of the present review was to report recently published papers, which highlight the novel mechanisms and treatments of AR, as well as the role of immunotherapy and biologics in the treatment of AR.

The current status of 2019-nCoV, the response, and proposals for bringing the outbreak under control are described and offered.

Recent advances in novel diagnostic biomarkers for tumor tissue, blood and stool samples in CRC patients are discussed.

Olorofim is the first member of the orotomide class of antifungals to be evaluated clinically for the treatment of invasive mold infections and has activity against many molds and thermally dimorphic fungi, but lacks activity against yeasts and the Mucorales.

There is an increasing interest in preparing bioactive peptides using novel technologies such as high hydrostatic pressure, ultrasounds, ohmic heating, pulsed electric fields, microwave-assisted extractions, and subcritical water hydrolysis.

An overview of the currently available information on the pathogenesis, epidemiology, clinical presentation, diagnosis, and treatment of the 2019-nCoV virus is presented.

While research has produced valuable insights about digital innovation, we lack a comprehensive understanding about its core nature, and research across disciplinary boundaries lacks integration. To address these issues, we review 227 articles on digital innovation across eight disciplines. Based on our findings, we (1) inductively develop a new definition and propose a new framing of current conceptualizations of digital innovation, (2) organize central concepts of the literature on digital phenomena and show how they intersect with our conceptualization, and (3) develop a framework to organi...

In this paper, we study the problem of Novel Class Discovery (NCD). NCD aims at inferring novel object categories in an unlabeled set by leveraging from prior knowledge of a labeled set containing different, but related classes. Existing approaches tackle this problem by considering multiple objective functions, usually involving specialized loss terms for the labeled and the unlabeled samples respectively, and often requiring auxiliary regularization terms. In this paper we depart from this traditional scheme and introduce a UNified Objective function (UNO) for discovering novel classes, with...

The development of an effective targeted therapy for a target that does not have a driver role in cancer development provides a novel drug development paradigm and claudin 18.2 as a validated therapeutic target is described.

Current pre-clinical and clinical findings are appraised, emphasizing metformin’s anti-inflammatory properties under individual pathophysiological scenarios, and there are still clinical perplexities to be addressed in repurposing met formin to inflammation-driven chronic diseases.

Observational knowledge of the epidemic intensity, defined as the number of deaths divided by global population and epidemic duration, and of the rate of emergence of infectious disease outbreaks is necessary to test theory and models and to inform public health risk assessment by quantifying the probability of extreme pandemics such as COVID-19. Despite its significance, assembling and analyzing a comprehensive global historical record spanning a variety of diseases remains an unexplored task. A global dataset of historical epidemics from 1600 to present is here compiled and examined using no...

Novel techniques in the field of breast imaging may soon play a role in breast cancer screening: digital breast tomosynthesis, contrast material-enhanced spectral mammography, US (automated three-dimensional breast US, transmission tomography, elastography, optoacoustic imaging), MRI (abbreviated and ultrafast, diffusion-weighted imaging), and molecular breast imaging.

The newly discovered roles of asprosin in metabolic diseases including diabetes, obesity, polycystic ovarian syndrome (PCOS), and cardiovascular disease (CVD), which may contribute to future clinical diagnosis and treatment are summarized.

The structure and action modes of EZH2 are summarized, focusing on up-to-date findings regarding the role of E zeste homolog 2 in cancer initiation, progression, metastasis, metabolism, drug resistance, and immunity regulation.

Novel food technologies are important for food security, safety and sustainability. Consumers, however, are often hesitant to accept them. In this narrative Review, we organize the research describing how heuristics and individual differences among consumers influence the acceptance of agri-food technologies. Associations evoked by a food technology, its perceived naturalness and trust in the industry using it influence consumer acceptance. Food neophobia, disgust sensitivity and cultural values are crucial personality factors for explaining individual differences. Using gene technology, nanot...

The novel coronavirus (2019-nCoV, or COVID-19) epidemic first broke out in Wuhan and has been spreading in whole China and the world with the continuous efforts of both national and international multi-sectoral bodies.

Novel and unexpected properties of PHA granules are described with respect to their contribution to stress tolerance of various prokaryotes including common mesophilic heterotrophic bacteria, but also extremophiles or photo-autotrophic cyanobacteria.

Stacking can outperform other models when compared with the other reported techniques that were implemented using the PIMA Indian diabetes dataset.

The historical milestones and prospective for further PROTACs development in clinical use are introduced, and several similar light-controllable PROTAC's are developed, termed as the third generation controllable PROTacs.

Novel and emerging biological treatments for major depressive disorder are assessed, their putative brain and body mechanisms are evaluated, and how close each might be to clinical use are highlighted.