Top Research Papers on Rheumatoid Arthritis

Almost one third of patients who received a diagnosis of seronegative rheumatoid arthritis have an alternative diagnosis than RA that can explain the arthritis, with paramalignant phenomenon, PMR and crystal arthritis being the most common.

Pro-inflammatory cytokines promote the development of systemic effects (anemia, car- diovascular disease, fatigue and depression).

The results of these studies indicate to the presence of subclinical myocardial involvement in RA, which can be ascribed to nonspecific myocarditis observed in this disease.

This study describes numerous genetic phenomena that may be implicated in the etiopathogenesis of RA i.e. antigens of major histocompatibility complex, genetic linkage analysis results of whole genome scan and polymorphism of several genes coding receptors, adhesion molecules and cytokines.

The results of these studies indicate to the presence of subclinical myocardial involvement in RA, which can be ascribed to nonspecific myocarditis observed in this disease.

The latest update of the EULAR recommendations for the treatment of RA maintain csDMARD (conventional systemic DMARDs) as the first line treatment, with methotrexate (MTX) still identified as the anchor drug.

The presented article is concern with a brief idea about rheumatoid arthritis, which is most common disease in India as well as outside India.

要旨 慢性関節 リウマチ(RA)は 自己免疫障害に起因 し,破 壊性の関節滑膜炎を主徴 とする全身 性疾患である.RAの 麻酔で留意すべ き点は,RAに 起因す る心,肺,腎,血 管系の機能低下,長 期の投薬な どに起因する虚血性心疾 患,癌,炎 症性疾患,貧 血,さ らに頸椎のRA性 変化 による 気道確保困難(difficult airway)な どがある.RAに 適する特別な麻酔薬はないが,鎮 痛,鎮 静薬 に対する感受性が高い点に注意が必要である.気 道確保困難 に対 し著者 らはラリンゲルマスクおよ び口マスクによるファイバー挿管法(口 マスク法)を 用いている.口 マスク法では全身麻酔下,筋 弛緩薬下に口マスクを用いて経口的換気を行 ないなが ら経鼻挿管を行なう.意 識下挿管 に伴 う患者 の苦痛がまった くないのが特長である. キーワー ド:慢 性関節 リウマチ;気 道確保困難;口 マスクファイバー挿管

Anticytokines are currently the most effective therapy for RA because of the rapid onset of action and the fact that they demonstratively lower the disease activity score and significantly slow the radiographic progression.

Patients who have not received the expected results after treatment with pharmacological preparations successfully use herbal remedies as a means of body restoring and healing as a means of body restoring and healing.

The levels of all markers were decreased significantly in RA patients after exposure to AuNPs or AuNps-PEG-Res, however, the levels of IgE, RF, ANA, dsDNA, C3, C4, and IL-33 showed significantly higher reduction in the presence of AuN Ps as compared to Au NPs-P EG-Res.

The aim of this review is to describe the role of gene variants located in immune system genes associated with susceptibility to rheumatoid arthritis.

There is high prevalence of PED in RA, it needs proper evaluation, treatment and urgent research is needed to know more about it.

Pro-inflammatory cytokines promote the development of systemic effects (anemia, cardiovascular disease, fatigue and depression).

The results showed that the ETN + MTX had the highest probability of being the most clinically efficacious intervention, with a surface under the cumulative ranking curve of 91.6, was significantly superior.

Sex hormones are implicated in immune response, with estrogens acting as enhancers, and metabolism of estrogen takes place primarily in the liver through Phase I (hydroxylation) and Phase II pathways with ultimate excretion in the urine and feces.

It has been revealed that the multi-organ dysfunction associated with AA amyloidosis causes the deterioration of RA prognosis.

The availability of T cell clones will clearly help in the near future to probe for the inducing antigen(s) in inflammatory rheumatic diseases thus rendering a basis for new immunotherapeutic approaches.

Germ-line TCR polymorphisms have now been extensively investigated in RA using the conventional approaches of genetic linkage analysis in affected sib pairs and also in case control studies of coding polymorphisms in variable gene segments, with varying results.

Fire needle therapy combined with cupping, ear pressure,embedding treatment of rheumatoid arthritis RA, a significant effect, non-toxic side effects, economic, convenient,worthy of promotion.

Assessment of serum CRP and RA factor as marker for rheumatoid arthritis found significant association between age group and CRP only and when the association between RA factor was determined, it was found highly significant (p<0.001).

This descriptive review aims to highlight the specific role of miRNAs in autoimmune processes, explicitly on their regulatory roles in the pathogenesis of RA, and its CV consequences, their main role as novel biomarkers, and their possible role as therapeutic targets.

Overall, this review shows consistent, supportive evidence that psychological interventions can significantly contribute to the standard medical care of RA patients, however, more high-quality, large-sample RCTs still need to confirm these findings.

Different European initiatives in the field and the successful effort to build a European Registry of at-risk people to facilitate observational and interventional research are described.

A static magnetic field may be more effective in reducing morning stiffness, whereas a pulsed magnetic field may, to a greater extent, improve function and reduce swelling in the rheumatoid hand.

Titers of LATEX and RAHA test showed a relative good correlation with clinical findings, but waaler-Rose test showed litle correlation.

This article focuses on cellular metabolic alterations in RA, related signalling pathways and possible drugs targeting RA metabolic pathways, which have been extensively studied for their therapeutic effects.

It is indicated that AKI developed in RA patients and suggested that renal function decline and prednisolone administration may be implicated.

The detection of anti-CCP in the diagnosis of patients with refractory rheumatoid arthritis and RA in remission showed higher sensitivity and specificity than RF assay.

Challenges in RA treatment and the advances in applications of CNTs for RA management are reported, consequently reflecting the CNTs as advanced drug delivery vehicles for arthritis treatment.

Pain syndrome in patients with neuropathic pain with symptomatic (NSAIDs, GC) and basic cytostatic therapy (methotrexate) showed that, despite the decrease in the severity of the inflammatory process, the positive dynamics was partial.

IBD, type 1 diabetes, and VTE might predispose to RA development, while cardiovascular disease, VTE, and OSA may result from RA, have important implications for RA pathogenesis, early detection, and recommended screening.

This information is used to document the scholarly activities of professional staff and students, which is an essential component of Wilford Hall Ambulatory Surgical Center (WHASC) internship and residency programs.

It was showed that patients with RA may have indications to bronchodilator therapy and have a need in dynamic control of LF and there was no connection between the character and severity of ventilatory disorders and activity of RA.

A review was undertaken of pathogenic mechanisms in early rheumatoid arthritis and strategies for cost-effective management of RA in the developing world and the importance of aggressive measurable disease control is emphasised.

Early diagnosis, adopting the right measures to promote good sleep quality, implementing pharmaceutical and non-pharmaceutical measures which will ease people’s pain and educational measures that will be offered to RA patients should be developed as strategies to minimize the negative impact caused by this disease.

The developed tool performs the pair wise alignment and analysis of the biological data of rheumatoid arthritis by calculating the mutability score and the obtained results may assist the doctors for improved diagnosis, treatment and prevention of the disease.

Anhand von 15 Schmerzparametern, die durch ein unterschiedliches Datenniveau charakterisiert sind, wurden 32 Patienten mit rheumatoider Arthritis (RA) unter Verwendung einer Clusteranalyse klassifiziert. Eine Untergruppe (n = 21) ist charakterisiert durch größere Schmerzintensität, ausgeprägtere sensorisch-diskriminative Schmerzqualität, durch Schmerzen in den Beinen, durch reduzierte thermische Aversionsschwellen und eine längere Erkrankungsdauer. Diese spezielle Untergruppe wurde anhand verschiedener klinisch-rheumatologischer Kriterien analysiert. Es zeigte sich dabei, daß kaum statistisch ...

It is important that rheumatology nurses, besides passing on medical treatment-related information, concentrate on RA patients' emotional well-being and avoid merely passing on information in a routine workmanlike way.

It was concluded that CYA was beneficial in management of RA patients and the main adverse effects were hypertrichosis, renal dysfunction and stomach pain.

従 来RAに 続発性 ア ミロイ ドー シスを合 併 した もの と診断された.

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This medicine was most plain that improving stiffness in morning and articulation function, reducing speed of ESR and RF, the effects of Yunke were safe and good, but the observing to the long dated effects of Kunke was needed observe.

Iraarticular injection of endostatin can be useful to RA patients and 68% of patients acquired clinical remission at last.

Patients with signs and symptoms of early rheumatoid arthritis (RA) should be referred to a multidisciplinary r heumatology clinic and the ACR-EULAR criteria help in identification of patients with risk for erosive RA.

The inflammatory process from synovial inflammation to cartilage and bone destruction is described, which notices that there are many problems to be solved in rheumatoid arthritis from the point of inflammatory process.

Compared with the 1987 criteria, the 2010 criteria classify more patients with RA at an earlier phase of the disease although overdiagnosis is an important issue to consider.

The Rheumatoids Arthritis Impact disease (RAID) was used for the evaluation of the impact of rheumatoid arthritis and the psychological status was evaluated using the Arabic validated version of the Hospital Anxiety and Depression scale (HADs).

MOI-RA is a simple and feasible index based on the ACR core data set of disease activity measures for assessment of diseaseactivity and treatment response in RA trials and clinical settings.