Top Research Papers on Rheumatoid Arthritis

Pro-inflammatory cytokines promote the development of systemic effects (anemia, car- diovascular disease, fatigue and depression).

The results of these studies indicate to the presence of subclinical myocardial involvement in RA, which can be ascribed to nonspecific myocarditis observed in this disease.

This study describes numerous genetic phenomena that may be implicated in the etiopathogenesis of RA i.e. antigens of major histocompatibility complex, genetic linkage analysis results of whole genome scan and polymorphism of several genes coding receptors, adhesion molecules and cytokines.

Almost one third of patients who received a diagnosis of seronegative rheumatoid arthritis have an alternative diagnosis than RA that can explain the arthritis, with paramalignant phenomenon, PMR and crystal arthritis being the most common.

The results of these studies indicate to the presence of subclinical myocardial involvement in RA, which can be ascribed to nonspecific myocarditis observed in this disease.

要旨 慢性関節 リウマチ(RA)は 自己免疫障害に起因 し,破 壊性の関節滑膜炎を主徴 とする全身 性疾患である.RAの 麻酔で留意すべ き点は,RAに 起因す る心,肺,腎,血 管系の機能低下,長 期の投薬な どに起因する虚血性心疾 患,癌,炎 症性疾患,貧 血,さ らに頸椎のRA性 変化 による 気道確保困難(difficult airway)な どがある.RAに 適する特別な麻酔薬はないが,鎮 痛,鎮 静薬 に対する感受性が高い点に注意が必要である.気 道確保困難 に対 し著者 らはラリンゲルマスクおよ び口マスクによるファイバー挿管法(口 マスク法)を 用いている.口 マスク法では全身麻酔下,筋 弛緩薬下に口マスクを用いて経口的換気を行 ないなが ら経鼻挿管を行なう.意 識下挿管 に伴 う患者 の苦痛がまった くないのが特長である. キーワー ド:慢 性関節 リウマチ;気 道確保困難;口 マスクファイバー挿管

The latest update of the EULAR recommendations for the treatment of RA maintain csDMARD (conventional systemic DMARDs) as the first line treatment, with methotrexate (MTX) still identified as the anchor drug.

Anticytokines are currently the most effective therapy for RA because of the rapid onset of action and the fact that they demonstratively lower the disease activity score and significantly slow the radiographic progression.

The presented article is concern with a brief idea about rheumatoid arthritis, which is most common disease in India as well as outside India.

The aim of this review is to describe the role of gene variants located in immune system genes associated with susceptibility to rheumatoid arthritis.

Sex hormones are implicated in immune response, with estrogens acting as enhancers, and metabolism of estrogen takes place primarily in the liver through Phase I (hydroxylation) and Phase II pathways with ultimate excretion in the urine and feces.

It has been revealed that the multi-organ dysfunction associated with AA amyloidosis causes the deterioration of RA prognosis.

The availability of T cell clones will clearly help in the near future to probe for the inducing antigen(s) in inflammatory rheumatic diseases thus rendering a basis for new immunotherapeutic approaches.

Pro-inflammatory cytokines promote the development of systemic effects (anemia, cardiovascular disease, fatigue and depression).

Germ-line TCR polymorphisms have now been extensively investigated in RA using the conventional approaches of genetic linkage analysis in affected sib pairs and also in case control studies of coding polymorphisms in variable gene segments, with varying results.

Fire needle therapy combined with cupping, ear pressure,embedding treatment of rheumatoid arthritis RA, a significant effect, non-toxic side effects, economic, convenient,worthy of promotion.

Assessment of serum CRP and RA factor as marker for rheumatoid arthritis found significant association between age group and CRP only and when the association between RA factor was determined, it was found highly significant (p<0.001).

Titers of LATEX and RAHA test showed a relative good correlation with clinical findings, but waaler-Rose test showed litle correlation.

The detection of anti-CCP in the diagnosis of patients with refractory rheumatoid arthritis and RA in remission showed higher sensitivity and specificity than RF assay.

It was showed that patients with RA may have indications to bronchodilator therapy and have a need in dynamic control of LF and there was no connection between the character and severity of ventilatory disorders and activity of RA.

It is important that rheumatology nurses, besides passing on medical treatment-related information, concentrate on RA patients' emotional well-being and avoid merely passing on information in a routine workmanlike way.

Anhand von 15 Schmerzparametern, die durch ein unterschiedliches Datenniveau charakterisiert sind, wurden 32 Patienten mit rheumatoider Arthritis (RA) unter Verwendung einer Clusteranalyse klassifiziert. Eine Untergruppe (n = 21) ist charakterisiert durch größere Schmerzintensität, ausgeprägtere sensorisch-diskriminative Schmerzqualität, durch Schmerzen in den Beinen, durch reduzierte thermische Aversionsschwellen und eine längere Erkrankungsdauer. Diese spezielle Untergruppe wurde anhand verschiedener klinisch-rheumatologischer Kriterien analysiert. Es zeigte sich dabei, daß kaum statistisch ...

The developed tool performs the pair wise alignment and analysis of the biological data of rheumatoid arthritis by calculating the mutability score and the obtained results may assist the doctors for improved diagnosis, treatment and prevention of the disease.

従 来RAに 続発性 ア ミロイ ドー シスを合 併 した もの と診断された.

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It was concluded that CYA was beneficial in management of RA patients and the main adverse effects were hypertrichosis, renal dysfunction and stomach pain.

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This article focuses on cellular metabolic alterations in RA, related signalling pathways and possible drugs targeting RA metabolic pathways, which have been extensively studied for their therapeutic effects.

Pain syndrome in patients with neuropathic pain with symptomatic (NSAIDs, GC) and basic cytostatic therapy (methotrexate) showed that, despite the decrease in the severity of the inflammatory process, the positive dynamics was partial.

A review was undertaken of pathogenic mechanisms in early rheumatoid arthritis and strategies for cost-effective management of RA in the developing world and the importance of aggressive measurable disease control is emphasised.

This medicine was most plain that improving stiffness in morning and articulation function, reducing speed of ESR and RF, the effects of Yunke were safe and good, but the observing to the long dated effects of Kunke was needed observe.

Iraarticular injection of endostatin can be useful to RA patients and 68% of patients acquired clinical remission at last.

Patients with signs and symptoms of early rheumatoid arthritis (RA) should be referred to a multidisciplinary r heumatology clinic and the ACR-EULAR criteria help in identification of patients with risk for erosive RA.

The inflammatory process from synovial inflammation to cartilage and bone destruction is described, which notices that there are many problems to be solved in rheumatoid arthritis from the point of inflammatory process.

Compared with the 1987 criteria, the 2010 criteria classify more patients with RA at an earlier phase of the disease although overdiagnosis is an important issue to consider.

Early diagnosis, adopting the right measures to promote good sleep quality, implementing pharmaceutical and non-pharmaceutical measures which will ease people’s pain and educational measures that will be offered to RA patients should be developed as strategies to minimize the negative impact caused by this disease.

This information is used to document the scholarly activities of professional staff and students, which is an essential component of Wilford Hall Ambulatory Surgical Center (WHASC) internship and residency programs.

IBD, type 1 diabetes, and VTE might predispose to RA development, while cardiovascular disease, VTE, and OSA may result from RA, have important implications for RA pathogenesis, early detection, and recommended screening.

MOI-RA is a simple and feasible index based on the ACR core data set of disease activity measures for assessment of diseaseactivity and treatment response in RA trials and clinical settings.

The Rheumatoids Arthritis Impact disease (RAID) was used for the evaluation of the impact of rheumatoid arthritis and the psychological status was evaluated using the Arabic validated version of the Hospital Anxiety and Depression scale (HADs).

The results confirm the hypothesis that the HLA-DRβ2 chain gene is closer related to the disease susceptibility of seropositive RA than the DRβ1 chain gene (DR4) and find a significant increase of Hla-DRw53 in patients with RF positive RA.

Inflammatory components of the DAS28 contribute minimally to fatigue and RA and OA fatigue levels do not differ, suggesting fatigue is not an inflammatory variable and has no unique association with RA or RA therapy.

The increased occurrence of inflammatory bowel disease and type 1 diabetes prior to RA suggests either a predisposition to RA development or a shared immunological defect, meriting further study.

Predictors of adherence to treatment of patients with RA are the young age patients, the onset of the disease before age of 39 years, and adherence to drug therapy and lifestyle modification.

There is high prevalence of PED in RA, it needs proper evaluation, treatment and urgent research is needed to know more about it.

The results showed that the ETN + MTX had the highest probability of being the most clinically efficacious intervention, with a surface under the cumulative ranking curve of 91.6, was significantly superior.

The vast majority of RA patients have low to medium adherence score, and advanced age, years of diagnosis and number of medication significantly affect disability score, however, there is no relationship between these factors and pain score.

Both intrinsic and extrinsic coagulation pathways, presumably triggered by the inflammatory process itself, are involved in articular fibrin deposition and it was shown that synovial fluids from RA patients stimulated the thromboplastin generation by normal human monocytes.

The respective diagnostic value each of diagnostic radiology and nuclear medicine in the detection of early rheumatoid arthritis is being demonstrated--with close correlation to its clinical presentation and course.

It is found that the sulphapyridine moiety penetrates the synovial membrane and also that it can modify immune function, and it is suggested that it should be used as an anchor drug in combination therapy to attempt to suppress disease activity further and limit joint damage.