Top Research Papers on Heterocyclic Compounds PDF

The present report summarizes the construction of four to eight-membered heterocyclic compounds containing nitrogen, oxygen and sulphur atoms through phosphine-catalyzed intramolecular annulations and intermolecular Annulations of electron-deficient alkenes, allenes, alkynes and Morita-Baylis-Hillman carbonates.

The high demand for new and efficient routes toward synthesis of nitrogen-containing heterocyclic scaffolds has inspired organic chem-ists to discover several methodologies over recent years, which involves the use of pyri-dotriazoles and related compounds in denitrogenative transformations.

This review surveys recent progress in the chemistry of polycyclic heteroaromatic molecules with a focus on structural diversity and synthetic methodology, providing an update to the first review of this topic in 2017.

This mini-review explores cytotoxic, cytoprotective, antinociceptive, anti-inflammatory, and antidepressant activities of some pyrazole analogs to advance structure-related pharmacological profiles and rational design of new analogs.

Nitrogen based heterocyclic compounds are extensively used as corrosion inhibitors because of their ability to form strong coordination bonding with the metallic atoms. In the present review article anticorrosive effect of pyridine based compounds is surveyed. Generally, pyridine derivatives with electron withdrawing and electron donating substituents showed higher anticorrosion effect than that of the native pyridine. Pyridine derivatives containing polar substituents at 2nd and 6th positions form highly stable chelating complexes. The mono- (2nd position) and di- (2nd and 6th position) subst...

This review highlights recent pioneering studies in the biological assessment of nitrogen-containing compounds, namely: triazoles, tetrazoles, imidazole/benzimidazols, pyrimidines, and quinolines, which will benefit researchers in medicinal chemistry and pharmacology.

This study examined synthesized some 5- or 6-ring N-heterocyclic compounds that showed the antiviral activity in last 5 years, and investigation of these compounds structure-activity relationship studies will be useful to scientists in research fields of organic synthesis, medicinal chemistry, and pharmacology.

This review aims to bring and discuss the detailed information on the antibacterial activity of various nitrogen-based heterocyclic compounds with nitrogen moiety that will be helpful for the future evolution of diseases to synthesize new and effective drug molecules.

Heterocyclic compounds with excellent nonlinear optical (NLO) properties are highly significant and have many potentials uses in various fields such as nuclear science, optoelectronics etc. Herein, an organic dye JK-201 was used theoretically to design a series of novel D-π-A based NLO molecules (DTA1-DTA12). This novel series of NLO molecules was quantum chemically designed by structural tailoring at the 1st π-spacer and acceptors unit of the JK-201 molecule. To explore the effect of spacers and acceptors on the electronic, photophysical, and NLO properties of DTA1-DTA12, density functional t...

The chemistry of heterocyclic compounds has traditionally been and remains a bright area of chemical science in Russia. This is due to the fact that many heterocycles find the widest application. These compounds are the key structural fragments of most drugs, plant protection agents. Many natural compounds are also derivatives of heterocycles. At present, more than half of the hundreds of millions of known chemical compounds are heterocycles. This collective review is devoted to the achievements of Russian chemists in this field over the last 15–20 years. The review presents the achievements o...

This unconventional transformation is orthogonal to traditional ring contractions, challenging the paradigm for diversification of heterocycles including piperidine, morpholine, thiane, Tetrahydropyran, and tetrahydroisoquinoline derivatives.

Bioinspired heterocyclic organic molecules have high significance as potential substitutes to the existing inhibitor chemistries, which are considered toxic and costly. Here, we provided a detailed review of the different kinds of heterocyclic macrocyclic compounds and biomolecules and their various chemically modified derivatives and composites as corrosion inhibitors. An account of typically used five, and six-membered heterocyclic compounds (basic constituents of biomolecules, drugs, etc.) is also provided. The review starts with a background of the different corrosion issues commonly encou...

Medicinal chemistry continues to be impacted by new synthetic methods. Particularly sought after, especially at the drug discovery stage, is the ability to enact the desired chemical transformations in a concise and chemospecific fashion. To this end, the field of organic synthesis has become captivated by the idea of 'molecular editing'-to rapidly build onto, change or prune molecules one atom at a time using transformations that are mild and selective enough to be employed at the late stages of a synthetic sequence. In this Review, the definition and categorization of a particularly promisin...

Efficient amination strategies for synthesis of N-heterocycles from functional molecules (bottom-up) or from biomass (top-down) via sustainable C–N/C–X bond chemistry.

A versatile method of N-atom excision from N-heterocycles is reported, which proceeds by N-sulfonylazidonation followed by the rearrangement of sulfamoyl azide intermediates, providing various cyclic products.

An overview of N-heterocyclic carbene catalyzed radical reactions via different synthetic techniques is given to provide a conceptual understanding of this emerging area.

A review article summarizes the results obtained with the isolated aNHCs, which successfully accomplished the metal-free catalytic formylation of amides using CO2 and the catalytic reduction of carbon dioxide, including atmospheric CO2, into methanol, under ambient conditions.

This review tries to present a comprehensive overview of top prescribed drugs containing nitrogen heterocycles, describing their pharmacological properties, medical applications and their selected synthetic pathways.

Modifications of different fatty acids with existing anticancer drugs and heterocyclic moieties by condensation reactions increased the tissue selectivity and made chemotherapy potentially more effective and less toxic in in vivo and in vitro studies.

The present article summarizes the recent development of both natural and synthetic spirooxindole-containing compounds prepared from isatin or its derivatives reported in the last five years.

Bulk-heterojunction polymer solar cells fabricated from M34 and a wide bandgap polymer as the donor showed a best power conversion efficiency (PCE) of 15.24% with an open circuit voltage (V OC) of 0.91 V, much higher than a PCE of 4.21% and a V OC of0.83 V for the counterparts based on M8:PM6.

This review highlights recent synthesis and reactions of user-friendly NHC-boryl radicals, which has contributed to radical chemistry, organoboron chemistry and polymer science, is comprehensively described.

This review focuses on the important progress of 3,4-heterocycle-fused coumarins providing better insight for medicinal chemists on the design and preparation of biologically active heterocycle/coumarins with a significant therapeutic effect in the future.

The effect of NHC structure, surface coverage, and substrate temperature on mobility, thermal stability, NHC surface geometry, and self-assembly is described.

N-heterocyclic carbenes (NHCs) represent one of the most important organic ligands in coordination chemistry, and have been recently attracting increasing attention in nanoscience. This review aims to provide an overview on recent research advances on the use of NHCs as stabilizing agents and functionality modifiers for metal nanoparticles (NPs) and nanoclusters (NCs). The review begins with the general introduction of NHCs and the initial discovery of NHC ligation on metal NPs. With the development of several effective strategies to decorate metal NPs with NHCs, the research enthusiasm for NH...

This review has highlighted the recent developments in designing and synthesis of various heterocyclic anti-inflammatory molecules along with detailed SAR studies and believes that lead compounds mentioned in the report will help to design and develop novel anti- inflammatory drug molecules targeting various factors involved in the progression of inflammation.

An electrochemical dehydrogenative method in which ammonia is inserted directly into alkenes to build aromatic N -heterocycles in a single step without the use of any external oxidant is shown, achieving 98–99.2% atom economy with hydrogen as the only byproduct.

N-Heterocyclic carbenes, despite being isolated and characterized three decades ago, still capture scientists' interest as versatile, modular and strongly coordinating moieties. In the last decade, driven by the increasingly refined fundamental understanding of their behaviour, the emergence of new carbene frameworks and cogent sustainability issues, N-heterocyclic carbenes have experienced a tremendous increase in utilization across several disparate fields. In this Review, a concise overview of N-heterocyclic carbenes encompassing their history, properties and applications in transition meta...

The authors show a method to generate aryl radicals from halides using only an NHC organocatalyst, and it is shown that the enolate form of the Breslow intermediate derived from an aldehyde and thiazolium-type NHC in the presence of a base undergoes single electron transfer to an aries iodide, providing an aryL radical.

A review article surveys the recent literature on Fe-NHC-catalyzed chemical reactions, including C-C bond formation, reduction, and oxidation reactions.

Fused heterocycles are unique building blocks for the synthesis of a wide range of high-performance energetic materials.

This feature article will mainly focus on heterocycle syntheses involving CO surrogates, including formic acid, formates, molybdenum hexacarbonyl, etc.

A number of elegant visible-light-induced, NHC-catalyzed transformations were developed for accessing valuable organic compounds and this minireview will highlight the recent advances in this field.

Abstract Phosphorus‐substituted heterocycles represent an important class of organophosphorus compounds, which not only widely exist in biologically active pharmaceuticals, agrochemicals, but also have widespread applications in material science and organic synthesis as ligands for transition metal complexes. The synthesis of such compounds integrates the development of new synthetic methods and exploration of efficient catalytic systems, reflects the latest achievements in organic, transition metal, photo and even electrochemical catalysis, and facilitates the synthesis of sufficient quantiti...

The results underline the importance of often overlooked steric interactions (Pauli repulsion) in conformational control of σ hole interactions and underlines the dispersion energies of the examined tellurium‐containing aromatics are far less important for the net attractive forces compared to the energies in the corresponding sulfur and selenium compounds.

Through discussing the role of NHC ligands in promoting challenging C-H activation methods, the reader is provided with an overview of this important area and its crucial role in forging carbon-carbon and carbon-heteroatom bonds by directly engaging ubiquitous C- H bonds.

This minireview highlights the recent progress and developments in NHC-based radical catalysis and is categorized according to the reaction types; oxidation type reaction and carbon–carbon bond formation through single electron transfer/radical–radical coupling.

The achievements made during the last 4 years toward broadening the applications of planar extended π-conjugated NHC ligands for the preparation of organometallic-based supramolecular structures are described, including their use as hosts for some selected organic and inorganic guests, together with the catalytic properties displayed by some selected host-guest inclusion complexes.

This work reviews the application of microwave irradiation for organic synthesis, organic synthesis in water and solvent-free synthesis in a combined manner and presents the synthesis of complex heterocyclic molecules using nanoparticles as catalysts, emphasizing green aspects of synthetic procedures.

In the present scenario, there has been a lot of consideration toward the field of free radical chemistry. Free radicals responsive oxygen species are produced by different endogenous frameworks, exposure to various physicochemical conditions, radiation, toxins, metabolized drug by-product, and pathological states. On the off chance that free radical overpowers the body's capacity, it generates a condition known as oxidative stress, which can alter physiological conditions of the body and results in several diseases. For appropriate physiological function, it is necessary to have a proper bala...