Top Research Papers on Heterocyclic Compounds PDF

It was discovered in the neoteric developments of heterocyclic compounds that these play a vital role in curative chemistry, and exert anticancer, anti-inflammatory, antifungal, antiallergic, antibacterial,anti-HIV, antiviral,Anti-convulsant, and other biological activities.

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Heterocyclic compounds represented by the general formula (I): (I) wherein X and Y are different from each other and are halo selected from among chloro, bromo and iodo, CF3SO3-, CH3SO3-, C6H5SO3-, or CH3C6H4SO3-; R1 is an optionally substituted monovalent aliphatic hydrocarbon group having two or more carbon atoms; one of A1 and A2 is-S-,-O-,-Se-or-Te-, while the other is-N=,-P=, or-Si(R2)= (wherein R2 is hydrogen, an optionally substituted monovalent hydrocarbon group, halogen, amino or carbonyl); and one of the two linkages each represented by a solid line and a broken line is a single bond...

The hit-to-lead optimization, which represents a crucial step in the early drug discovery process, aims at improving the drug-likeness by modifying physicochemical properties, improving pharmacokinetic/pharmacodynamic (PD) profiles, and reducing off-target activities.

Isatin (1H-indole-2,3-diones) and its derivatives are a unique structure of heterocyclic molecules with great synthetic versatility and enormous biological activities of interest. Isatins have been broadly used as building blocks for the formation of a wide range of N-heterocycles. These applicable compounds undergo various reactions to form new heterocyclic compounds. The focus of this review is to summarize the recent literature and key reactions published about Pfitzinger, ring-opening, and ring expansion reactions of isatin and its derivatives during the period from 2018 to 2020. We beli...

Abstract Heterocycles have maintained their popularity among researchers in all these years due to their important activities in pharmaceuticals. Several reports on the synthesis of heterocycles including coumarin, pyran, oxazole, and thiazole for drugs have been published. The O-heterocycles are present in drugs like rantidine, doxepin, and paclitaxel. Various diketones such as β-diketones, 1,3-diketones, 1,4-diketones and dicarbonyl compounds play a vital role in synthetic organic chemistry and are used in the synthesis of core heterocyclic compounds. This review article covers the syntheses...

Heterocyclic compounds with diverse structures can be synthesized using various methods, enabling the design of molecules with desired properties, underscoring their crucial role in medicinal chemistry.

Various synthetic procedures of thiadiazole derivatives along with their pharmacological activities are shown and also the recent studies on Antiviral targets for the discovery of new drugs to combat Covid19 like viruses are reviewed.

Heterocyclic compounds provide a fascinating research area for the design and development of anticancer drug(s) and efforts have been made towards the mechanism of action of selected heterocyClic anticancer compounds.

The chemistry of heterocyclic compounds such as Quinoxaline, Triazole, Pyrimidine, Pyridine, Oxadiazole, Thiazoles, Indole, and Azepine are discussed.

Naturally occurring heterocyclic scaffolds are key ingredients for the development of various therapeutics employed for biomedical applications and are displayed here along with their molecular level cytotoxic action and therapeutic applications.

A comprehensive review of synthetic tyrosinase inhibitors possessing heterocyclic moieties reported within the last five years is reported, which classified them as inhibitors of mushroom tyros inase (Agaricus bisporus) and human tyosinase.

Azomethine ylides are nitrogen-based three-atom components commonly used in [3+2]-cycloaddition reactions with various unsaturated 2π-electron components. These reactions are highly regio- and stereoselective and have attracted the attention of organic chemists with respect to the construction of diverse heterocycles potentially bearing four new contiguous stereogenic centers. This review article complies the most important [3+2]-cycloaddition reactions of azomethine ylides with various olefinic, unsaturated 2π-electron components (acyclic, alicyclic, heterocyclic, and exocyclic ones) reported...

This review is limited to the antitumor activity of xanthones and the chemistry ofxanthone core, which may help provide fundamental knowledge to the medicinal chemist for new and advanced research in drug development.

公开了一种由式1A表示的杂环化合物和一种包括该杂环化合物的有机发光装置：式1AR1至R13中的至少一个是由下面的式1B表示的基团：式1B其中，R1至R15、Ar1、Ar2、A、B、a和b如说明书中所定义。 该有机发光装置可包括包含该杂环化合物的有机层，因此可具有低驱动电压、高发射效率和长寿命特性。

This work includes preparing of some new derivatives of pyrimidine,pyrazolidine, and isoxazolidine from the reaction between tetraethyl and ammonia derivatives in dry ethanol to obtain six membered hetero rings.

This review is focused on sulphur containing heterocyclic compounds as anticancer agents, and azoles such as thiazole and thiadiazole structures have gained prominence in cancer research.

An extensive review of the antiviral activity of five-membered heterocyclic compounds reported from 2015 to date, containing the specified ring systems thiadiazole, triazoles, oxadiazoles, and thiazoles are discussed.

OIL organic matter is an essential component of fertility of soils, ..... especially the sandy ones. It also accounts for increasing the emission of the greenhouse gases (GHG). Efficient managements of applied organic amendments to soil are required to reduce GHG emission. The current research aimed at investigating the effects of farm yard manure and compost applied at two different rates, i.e., 24 and 48 Mg ha using shallow (0-10 cm) or deep (0-20 cm) tillage operations on improving the physical properties of the studied soil, carbon sequestration in soil and its relation to the wheat and ma...

In particular there is provided a compound of formula (I) as defined in the present specification p38 MAP kinase inhibitors for use as a medicament for the treatment of inflammatory diseases.

The mechanism, challenges, and applications of heterocyclic compounds as corrosion inhibitors in various industrial relevant corrosive environments such as acid pickling, descaling operation in the desalination plant, oil gas industry, etc., have also been highlighted in the review.

Proposed compounds are inhibitors of calcium channel function being especially inhibitor of K v 1 subfamily of potential-overlapping K + -channels and especially inhibitors ofK v 1.5 that associated with super-rapid activating delayed cleaning K +-flow of I kur and can be used in treatment of arrhythmia and IKur -associated diseases.

The present invention provides pharmaceutical compositions comprising compounds of Formula I and methods of treating or preventing one or more conditions that may be regulated or normalized via inhibition of dipeptidyl peptidase IV (DPP-IV).

New heterocyclic compounds of the formula (I) (wherein, R 1, D, W, T, and T has the meanings indicated in claim 1) is a SGK inhibitors, SGK may be used for the treatment of induced diseases and conditions.

The compound is useful as a medicinal ingredient having a CRF antagonistic activity for use in the prevention and/or treatment of a neurological/psychiatric disease, a disease in a terminal organ or the like.

The present invention provides a compound with the unexpected insecticidal activity. A compound of formula (I): [Formula 1] Preferred compounds are, How to spraying the compounds of formula (I), the composition consisting of optionally the second compound and the carrier and this if you are a pest.

Compounds of the present invention as depression, schizophrenia, Alzheimer's disease or attention deficit hyperactivity disorder (ADHD) and other drugs useful for the prophylaxis or treatment.

(57) Abstract: The present invention relates to a process for the production of intermediates useful for preparing the therapeutically active azacyclic or aza bicyclic compounds.

A selected from Formula 1 or Formula 1A compound, its N-oxides and salts, ** ** Formula wherein E is ** ** Formula Y1, Y2 and Y3 in formula 1 form a ring selected from ** ** formula wherein the bond projecting to the left, marked with a * in L-1, L-2 and L-9 is attached to E in formula 1 and the bond projecting to the right, marked with a T, it is connected to G in Formula 1; Y2, X1 and X2 in Formula 1A form a ring selected from ** ** Formula wherein the bond projecting to the left, marked with a * in L-60 and L-64, is attached to E in Formula 1A and the bond projecting to the right, marked wi...

A useful antidepressant compound showing inhibition of 5-HT reuptake is provided, and its application in clinical practice is still under investigation.

The patent application relates to new heterocyclic compounds of the general formula (I), in which R, R1, R2, Q, T, n and p have the definitions elucidated in more detail in the description, to a process for preparing them and to the use of these compounds as medicaments, particularly as aldosterone synthase inhibitors.

A compound represented by the formula (I) or a salt of the compound is a tyrosinkinase inhibitor or a preventive/therapeutic agent for cancers which each contains the compound or a prodrug thereof.

The present invention provides a PDE9 inhibitor compound of formula (I) and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing compounds of formula I and their use in the treatment of neurodegenerative and cognitive disorders such as Alzheimer's disease and schizophrenia.

PURPOSE: To obtain a new nitrogen heterocyclic compd. effective in treating hypertension, congestive heart failure, etc. CONSTITUTION: The nitrogen heterocyclic compd. is a compd. of formula I [where R 1 is H, alkyl, phenyl, etc.; R 2 is H, alkyl or cycloalkyl; R 3 is R 1 , a halogen, alkoxy, amino, etc.; R 4 is H, amino, OH, alkoxy, alkyl, carboxy, CN, NO 2 , phenyl, etc.; R 5 is H; R 6 is H or alkyl; R 7 is H, alkyl, alkoxy, halogen, CN, etc.; X is phenylene or a direct bond; Rz is H, alkyl, alkanoyl or benzoyl; and Z is 1H-tetrazol-5-yl, COOR 8 (R 8 is H, the residue of a physiologically ac...

THE INVENTION RELATES TO THE PREPARATION OF HETEROCYCLIC COMPOUNDS. IT RELATES TO A METHOD OF PREPARATION OF A COMPOUND OF THE GENERAL FORMULA (CF DRAWING IN BOPI) R REPRESENTS OR ATOM HYDROGEN OR GROUP MAY BE sUBSTITUTED alkyl or cycloalkyl, R REPRESENTS A GROUP MAY BE sUBSTITUTED alkyl or cycloalkyl, R EACH AND REGARDLESS R REPRESENTS A GROUP alkyl or cycloalkyl MAY SUBSTITUTE AND EACH R AND R REPRESENTS INDEPENDENT GROUP alkyl, cycloalkyl, alkenyl, alkynyl, aRYL OR optionally substituted aralkyl, INCLUDING THE REACTION OF hYDRAZONE APPROPRIATE WITH A SUITABLE DICARBOXYLATE. PRODUCTS ARE USE...

All that are described are novel heterocyclic compounds of general formulae and (values of radicals are given in invention formula), pharmaceutical compositions containing them and application of said heterocyClic compounds for treatment disorders mediated with MAP kinase cascade.

The compounds of the present invention is useful for diseases such as chronic obstructive pulmonary disease, cancer or the treatment and / or prevention of skin disorders.

All geometric and stereoisomers, tautomers, and the compounds of formula 1 is disclosed containing the N- oxides and salts, [Formula 1] In the formula, E, X, Y, G, Z and Q are as defined in the present disclosure. The compositions containing the compounds of formula 1, and, a method for controlling plant diseases caused by fungal pathogens comprising applying an effective amount of a compound or composition of the present invention is disclosed.

The present invention provides compounds of formula (I) and salts thereof, wherein Ring A is an optionally substituted 5 to 10 membered aromatic ring; R

A review of the literature on the synthesis of heterocycles revealed several that produced significant yields and could be modified for the organic laboratory.

The present invention is also a process for preparing the compounds described above, and pharmaceutical compositions containing them, as well as to the use of these.

The present application provides compounds of formula (I) that modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives.

PURPOSE: To provide a new sulfinylation process of a heterocyclic compound wherein the difficulty of oxidation and the toxicity of reactants are avoided. CONSTITUTION: A compound of the formula: RS(O)X [wherein R is a 1-4C, linear or branched alkyl substituted by one or more halogens; and X is a halogen, OH, NR 2 R 3 (wherein R 2 and R 3 are each a 1-4C alkyl or 1-4C haloalkyl) or aryloxy (wherein the aryl portion is preferably phenyl which is optionally substituted by one or more halogens, 1-4C alkyl or 1-4C haloalkyl)] is allowed to react with a heterocyclic compound chosen from the group co...

The present invention includes a method which comprises administering an effective amount of a compound (I) for the required certain mammals.

The configuration of the present invention is a compound of formula (I), its salts and solvates thereof, in the preparation of these compounds, pharmaceutical formulations containing these compounds and their use in medicine, particularly in the treatment of migraine applications. Structural formula (I) above.

本発明は、一般式（Ｉ）（式中、ＤおよびＧは、置換基を有していてもよい環状基、または置換基を有していてもよいアルキル基を表わし、ＷおよびＹは、結合手または主鎖の原子数１〜４のスペーサーを表わし、環Ａおよび環Ｂは、少なくとも１個の炭素原子および少なくとも１個の窒素原子を含有してなる、置換基を有していてもよい複素環を表わし、環Ａと環Ｂは１個のスピロ炭素原子を共有する。）で示される化合物、その塩、そのＮ−オキシド体、それらの溶媒和物、またはそれらのプロドラッグに関する。 一般式（Ｉ）で示される化合物はＭＢＲに親和性を有するため、ストレスに起因する疾患の予防および／または治療薬として有用である。

A fused heterocyclic compound having an enteropeptidase inhibitory action and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided.

A compound having the general formula (I), or a pharmacologically acceptable salt thereof, wherein each substituent has the following values: r and R, each optionally predstavlyayutatom hydrogen or a group selected from Substituent group α, or together form a substituents having regard for two provisions.

Methods for the synthesis of heterocyclic compounds including N-(3,5~dichloropyrid-4-yl)-4- difluoromethoxy-8-methanesulfonamido-dibenzo[b,d]furan-l-carboxamide and pharmaceutically acceptable salts thereof.

The IUPAC Gold Book describes heterocyclic compounds as: “Cyclic compounds having as ring members atoms of at least two different elements, e.g. quinoline, 1,2-thiazole, bicyclo[3.3.1]tetrasiloxane” [1]. Usually they are indicated as counterparts of carbocyclic compounds, which have only ring atoms from the same element. Another classical reference book, the Encyclopaedia Britannica, describes a heterocyclic compound, also called a heterocycle, as: “Any of a class of organic compounds whose molecules contain one or more rings of atoms with at least one atom (the heteroatom) being an element ot...