Dextran 40 and Thromboembolism in Total Hip Replacement Surgery
Archives of SurgeryPublished 1 February 1973
Joel E. Rothermel
Citations39
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TL;DR
No effect on morbidity from thromboembolic diseases was observed in patients selected randomly after total hip replacement as compared with control patients randomly selected in a similar fashion and not receiving dextran.
Abstract
Sixty patients selected randomly were given dextran 40 after total hip replacement, 500 ml each day for three days, and then on alternate days until the seventh to 14th day. No effect on morbidity from thromboembolic diseases was observed in them as compared with sixty control patients randomly selected in a similar fashion and not receiving dextran.
Keywords
Medicine
Journal of Bone and Joint SurgeryPrevention of Thromboembolic Disease after Elective Surgery of the Hip
165 Citations1971Charles M. Evarts, Edward J. Feil
The prophylactic administration of low molecular weight dextran is recommended for patients undergoing elective surgery of the hip and has a marked protective effect against the occurrence of thromboembolism.
Journal of Bone and Joint SurgeryThe Prevention of Thromboembolic Disease By Prophylactic Anticoagulation
89 Citations1967William H. Harris, Edwin W. Salzman +1 more
A statistically significant protective effect against the occurrence of thromboembolic disease has been demonstrated in a controlled series of 169 elective hip operations in 137 consecutive patients by the use of prophylactic anticoagulation with warfarin.
BMJDextran 70 in Prophylaxis of Postoperative Venous Thrombosis. A Controlled Trial
65 Citations1970James Lambie, D. C. Barber +2 more
A controlled prospective trial was carried out in a group of 80 women undergoing gynaecological surgery and thought to be at risk of developing postoperative venous thrombosis, finding the protective effect of dextran 70 is significantly better than that of warfarin (P<0·01).
Archives of SurgeryDextran 40 and Dextran 70
57 Citations1967M Atik
Two preparations of dextrans are suitable for clinical use: a medium molecular weight dextran preparation which is commercially available and a low molecular weight Swedish preparation (Rheomacrodex, with average molecular weight of 40,000) which is available for investigation only.