cis-Acting DNA from Fission Yeast Centromeres Mediates Histone H3 Methylation and Recruitment of Silencing Factors and Cohesin to an Ectopic Site
Current BiologyPublished 1 October 2002Open access
Janet F. Partridge, Kristin S. Caruana Scott, Andrew J. Bannister, Tony Kouzarides, Robin C. Allshire
Citations178
SJR quartileQ1
SJR score2.71
SNIP1.83
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TL;DR
Recruitment of Rad21-cohesin underscores the link between heterochromatin and chromatid cohesion and indicates that these centromeric elements act independently of kinetochore activity to recruit cohesin.
Abstract
A short sequence, reiterated at fission yeast centromeres, can direct silent chromatin assembly and cohesin recruitment in a dominant manner. The heterochromatin formed at the euchromatic locus is indistinguishable from that found at endogenous centromeres. Recruitment of Rad21-cohesin underscores the link between heterochromatin and chromatid cohesion and indicates that these centromeric elements act independently of kinetochore activity to recruit cohesin.
Keywords
Agricultural and Biological SciencesBiochemistry, Genetics and Molecular Biology
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