Genome-wide Association Study of Smoking Initiation and Current Smoking
The American Journal of Human GeneticsPublished 1 March 2009Open access
Jacqueline M. Vink, August B. Smit, Eco J. C. de Geus, Patrick F. Sullivan, Gonneke Willemsen, Jouke‐Jan Hottenga
Citations133
SJR quartileQ1
SJR score4.53
SNIP2.47
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TL;DR
It is concluded that a network-based genome-wide association approach can identify genes influencing smoking behavior.
Abstract
For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples (n = 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior.
Keywords
Biochemistry, Genetics and Molecular BiologyMedicineNursing
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