Transporters and xenobiotic disposition

This review will outline relevant background information regarding drug transporters and the role of suchtransporters in the drug disposition process and suggest transport and metabolism must be considered together to better predict drug disposition in vivo.

Abstract

Metabolism alone does not adequately account for the observed intersubject variability in drug disposition or response. Carrier-mediated processes, or transporters, are increasingly recognized to be importantly involved in drug absorption, distribution, and excretion. Thus for many drugs, transport and metabolism must be considered together to better predict drug disposition in vivo. Accordingly, this review will outline relevant background information regarding drug transporters and the role of such transporters in the drug disposition process.