Patterned Activity, Synaptic Convergence, and the NMDA Receptor in Developing Visual Pathways
Annual Review of NeurosciencePublished 1 March 1990
Martha Constantine‐Paton, Hollis T. Cline, E.A Debski
Citations781
SJR quartileQ1
SJR score7.11
SNIP3.24
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Article de synthese a propos de l'existence d'une association entre la transmission par l'activation des recepteurs NMDA and les contacts explorateurs entre les neurones en developpement, pour definir une plasticite plus prononcee au niveau de certaines regions du cerveau.
Abstract
The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Keywords
Neuroscience
NatureMagnesium gates glutamate-activated channels in mouse central neurones
4,022 Citations1984Linda M. Nowak, Pìotr Bregestovski +3 more
The voltage dependence of the NMDA receptor-linked conductance appears to be a consequence of the voltage dependenceof the Mg2+ block and its interpretation does not require the implication of an intramembrane voltage-dependent ‘gate’.
NatureVoltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones
2,881 Citations1984Mark L. Mayer, Gary L. Westbrook +1 more
Using voltage-clamp experiments on mouse spinal cord neurones, it is shown that the voltage-sensitivity of NMDA action is greatly reduced on the withdrawal of physiological concentrations (∼1 mM) of Mg2+ from the extracellular fluid, providing further evidence that Mg 2+ blocks inward current flow through ion channels linked to NMDA receptors.
Philosophical transactions of the Royal Society of London. Series B, Biological sciencesPlasticity of ocular dominance columns in monkey striate cortex
1,659 Citations1977David H. Hubel, Torsten N. Wiesel +3 more
Preliminary experiments suggest that the layer IVC columns in juvenile macaque monkeys are not fully developed until some weeks after birth, which explains the critical period for deprivation effects in the layerIV columns.
NatureSelective stabilisation of developing synapses as a mechanism for the specification of neuronal networks
1,441 Citations1976Jean‐Pierre Changeux, Antoine Danchin
The alternative proposed in this article is that connections are genetically specified between classes of cells, but the final wiring pattern depends on the refinement of those collections by selective stabilisation during neuronal activity.
The Journal of Comparative NeurologyThe development of ocular dominance columns in normal and visually deprived monkeys
1,133 Citations1980Simon Le Vay, Torsten N. Wiesel +1 more
The main purpose of this study was to examine the normal postnatal development of ocular dominance columns in the striate cortex of the macaque monkey and to determine how this developmental process is influenced by monocular lid‐suture.
ScienceThe Biochemistry of Memory: A New and Specific Hypothesis
1,045 Citations1984Gary Lynch, M Baudry
A synaptic process with properties required for an intermediate step in memory storage is uncovered and hypothesized to be responsible for those forms of memory localized in the telencephalon.
NatureLong-term potentiation and NMDA receptors in rat visual cortex
966 Citations1987Alain Artola, Wolf Singer
ScienceBlockade of "NMDA" Receptors Disrupts Experience-Dependent Plasticity of Kitten Striate Cortex
911 Citations1987Andreas Kleinschmidt, Mark F. Bear +1 more
Data support the hypothesis that crucial variables for the expression of activity-dependent synaptic modifications are a critical level of postsynaptic activation and calcium entry through ion channels linked to NMDA receptors.
NatureModulation of visual cortical plasticity by acetylcholine and noradrenaline
865 Citations1986Mark F. Bear, Wolf Singer
The results suggest that intracortical 6-OHDA disrupts plasticity by interfering with both cholinergic and noradrenergic transmission and raise the possibility that ACh and NA facilitate synaptic modifications in the striate cortex by a common molecular mechanism.
Annual Review of NeuroscienceLong-Term Potentiation
802 Citations1987Timothy J. Teyler, Pascal DiScenna
The available evidence suggests that L TP does occur in conjunction with behavioral learning-although whether it is necessary and sufficient is far from certain.
The Journal of PhysiologyOcular dominance in layer IV of the cat's visual cortex and the effects of monocular deprivation.
701 Citations1978Carla J. Shatz, Michael P. Stryker
The findings suggest that the thalamocortical projection is physically rearranged as a consequence of monocular deprivation, as has been demonstrated for layer IVc of the monkey's visual cortex.
Journal of NeuroscienceBinocular impulse blockade prevents the formation of ocular dominance columns in cat visual cortex
692 Citations1986Michael P. Stryker, WA Harris
Assays indicated that retinal blockade completely blocked the formation of ocular dominance columns, unlike any of the control procedures, suggesting that the spontaneous maintained discharge of retinal ganglion cells may have an important role in the normal development of binocular connections in the visual cortex.
ScienceVisual Experience Modifies Distribution of Horizontally and Vertically Oriented Receptive Fields in Cats
594 Citations1970Helmut V. B. Hirsch, Donatella Spinelli
Elongated receptive fields of cells in the visual cortex were horizontally or vertically oriented—no oblique fields were found and units with horizontal fields were activated only by the eye exposed to horizontal lines; units with vertical fieldsonly by the eyes exposed to vertical lines.
ScienceA Physiological Basis for a Theory of Synapse Modification
537 Citations1987Mark F. Bear, Leon N. Cooper +1 more
The question of how synapses modify according to experience has been approached by determining theoretically what is required of a modification mechanism to account for the available experimental data in the developing visual cortex, and the resulting theory states precisely how certain variables might influence synaptic modifications.
Proceedings of the National Academy of SciencesN-methyl-D-aspartate receptor antagonist desegregates eye-specific stripes.
531 Citations1987Hollis T. Cline, E.A Debski +1 more
Exposure of the optic tectum to NMDA results in stripes with sharper borders and fewer forks and fusions than untreated animals, suggesting that the NMDA receptor/channel plays a role in eye-specific segregation in the three-eyed tadpole.
Annual Review of NeuroscienceMotor Nerve Sprouting
529 Citations1981Michael C. Brown, R. L. Holland +1 more
The Journal of PhysiologyReversal of the physiological effects of monocular deprivation in kittens: further evidence for a sensitive period
459 Citations1974Colin Blakemore, Richard C. Van Sluyters
It was confirmed that suturing the lids of one eye (monocular deprivation), until only 5 weeks of age, leaves virtually every neurone in the kitten's visual cortex entirely dominated by the other eye.
NatureNMDA receptors in the visual cortex of young kittens are more effective than those of adult cats
443 Citations1987Tadaharu Tsumoto, Kenta M. Hagihara +2 more
It is reported that during the critical period in young kittens, a selective NMDA-receptor antagonist blocks visual responses of cortical neurons much more effectively than it does in the adult cat, suggesting that NMDA receptors may be involved in establishing synaptic plasticity in the kitten visual cortex.
Annual Review of PsychologyVisual Neural Development
414 Citations1981J. Anthony Movshon, Richard C. Van Sluyters
The results show clear trends in normal development and effects of deprivation, which are related to species isolation, rearing, and electrophysiology.
The Journal of Comparative NeurologyBinocular competition in the control of geniculate cell growth
336 Citations1972R. W. Guillery
This work has shown that geniculate laminae that are visually deprived by a unilateral lid‐suture grow less than normal, but the most lateral part of lamina A, which is innervated from the monocular crescent of the visual field and which extends beyond the edge ofLamina A1, is not affected by lid‐Suture.
The Journal of Comparative NeurologyThe differential effects of unilateral lid closure upon the monocular and binocular segments of the dorsal lateral geniculate nucleus in the cat
315 Citations1970R. W. Guillery, Dennis J. Stelzner
The observations are consistent with the view that during normal development geniculate cell axons from adjacent laminae compete with each other for synaptic surfaces upon binocular cortical neurons: that unilateral lid suture upsets the balance of this competition and that the reduced perikaryal growth in the lateral geniculated nucleus is secondary to the unbalanced axonal development.
Journal of NeuroscienceThe location and function of NMDA receptors in cat and kitten visual cortex
308 Citations1989Kevin Fox, Hiromichi Sato +1 more
The rapid change in the functional effect of NMDA receptors over the third and fourth week in granular and deep layers suggests a role in development and there was a reasonable age correlation between the change in effect and the period of geniculocortical afferent segregation.
Annual Review of NeuroscienceFormation of Topographic Maps
307 Citations1988Susan B. Udin, J W Fawcett
The catalogue of data presented here form many systems demonstrates that multiple mechanisms are involved in the formation of topographic maps and that at least some form of chemospecificity can be invoked to help explain connectivity in all of the experiments.
NeuronNMDA receptor antagonists disrupt the retinotectal topographic map
290 Citations1989Hollis T. Cline, Martha Constantine‐Paton
Neither treatment with L-APV nor with NMDA disrupts the fidelity of the retinotectal projection, and data support a role for the NDMA receptor in visual system development.
SciencePharmacological Induction of Use-Dependent Receptive Field Modifications in the Visual Cortex
278 Citations1988Joachim M. Greuel, Heiko J. Luhmann +1 more
ScienceSuppression of Neurite Elongation and Growth Cone Motility by Electrical Activity
276 Citations1986Christopher S. Cohan, Stanley B. Kater
It is demonstrated that growth cone advance, and thus neurite elongation, is reversibly stopped during periods when action potentials are experimentally evoked.
NeuroscienceLong-term potentiation in the dentate gyrus: induction and increased glutamate release are blocked by d(−)aminophosphonovalerate
270 Citations1987M.L. Er̀rington, Marina A. Lynch +1 more
D(-)Aminophosphonovalerate, a specific antagonist of the N-methyl-D-aspartate subtype of glutamate receptor, was perfused through a push-pull cannula into the dentate gyrus of rats anaesthetized with urethan in order to observe its effect on the induction and maintenance of long-term potentiation and on the increase in release of endogenous glutamate associated with long- term potentiation.
Proceedings of the National Academy of SciencesNeural plasticity without postsynaptic action potentials: less-active inputs become dominant when kitten visual cortical cells are pharmacologically inhibited.
269 Citations1988Holger O. Reiter, Michael P. Stryker
Results indicate that the post Synaptic cell is crucially involved in plasticity of the visual cortex, that the direction of cortical plasticity depends on postsynaptic membrane conductance or polarization, and that plasticity can occur in the absence of post synapse spike activity.
ScienceEye-Specific Termination Bands in Tecta of Three-Eyed Frogs
263 Citations1978Martha Constantine‐Paton, Margaret I. Law
An extra eye primordium was implanted into the forebrain region of embryonic Rana pipiens, during development both normal and supernumerary optic tracts terminated within a single, previously uninnervated tectal lobe.
Journal of NeurophysiologyCorrelated firing of cat retinal ganglion cells. I. Spontaneously active inputs to X- and Y-cells
257 Citations1983David N. Mastronarde
These correlations in maintained firing appear to be principally or entirely caused by shared inputs to the ganglion cells from more distal retinal neurons, which appear to have strong, brief, well-defined effects on ganglions, which are observed even in the absence of a visual stimulus.
Brain ResearchActivity sharpens the map during the regeneration of the retinotectal projection in goldfish
250 Citations1983John T. Schmidt, D. Louise Edwards
The Journal of PhysiologyThe physiological effects of monocular deprivation and their reversal in the monkey's visual cortex.
234 Citations1978Colin Blakemore, L.J. Garey +1 more
Even within layer IV c there was evidence for re‐expansion of physiologically determined ocular dominance stripes, and in all animals most cells outsidelayer IV c were orientation‐selective, and preferred orientation usually shifted from cell to cell in a regular progressive sequence.
The Journal of PhysiologyThe effects of early visual experience on the cat's visual cortex and their possible explanation by Hebb synapses.
222 Citations1981Josef P. Rauschecker, Wolf Singer
It was confirmed that most cortical neurones prefer vertical stimulus orientations when experience is restricted to vertical contours in both eyes, and that, if the experienced orientations are different in the two eyes, each eye dominates over those neurones whose orientation preference corresponds to the orientation this eye has experienced.
The Journal of Comparative NeurologyChanges in the postsynaptic density with long‐term potentiation in the dentate gyrus
207 Citations1986Nancy L. Desmond, William B. Levy
Changes in the size of the postsynaptic density (PSD) of synapses formed by entorhinal afferents with granule cell dendritic spines with long‐term potentiation with LTP are documents.
NatureKetamine—xylazine anaesthesia blocks consolidation of ocular dominance changes in kitten visual cortex
205 Citations1987Josef P. Rauschecker, Sabine Hahn
It is reported here that an ocular dominance shift is prevented in alert kittens that receive repeated brief monocular exposures when these are followed by ketamine–xylazine anaesthesia, suggesting that the process by which synaptic activity is converted into structural changes has been disturbed.
Developmental Brain ResearchTetrodotoxin inhibits the formation of refined retinotopography in goldfish
191 Citations1983Ronald L. Meyer
One optic nerve of mature goldfish was crushed in the orbit and allowed to regenerate, and TTX had no effect on the time-course and quality of the regeneration of gross topography seen with half retina mapping, but indefinitely inhibited higher order retinotopography normally seen by 2 months with retina sector mapping.
ScienceTetrodotoxin Blocks the Formation of Ocular Dominance Columns in Goldfish
188 Citations1982Ronald L. Meyer
Optic fibers from both eyes were made to regenerate simultaneously into one tectum in goldfish and regenerating left and right fibers overlapped extensively for up to 4 weeks and subsequently segregated into eye dominance columns by 8 weeks.
The Journal of PhysiologyCentral gating of developmental plasticity in kitten visual cortex
184 Citations1982Wolf Singer, Felix Tretter +1 more
In nine 4‐week‐old, dark‐reared kittens the authors sutured one eye closed and rotated the other surgically and the kittens then grew up in a normally lighted animal colony with adequate room to play.
Journal of NeuroscienceA role for action-potential activity in the development of neuronal connections in the kitten retinogeniculate pathway
179 Citations1986MW Dubin, Louisa A. Stark +1 more
The basic finding is that there is improper segregation of retinal inputs onto LGN cells after prolonged retinal action-potential blockade, which is consistent with the idea that normally synchronous activity of neighboring ganglion cells of like center-type may be used in the refinement of retinogeniculate synaptic connections.
Journal of NeurophysiologyPostcritical-period reversal of effects of monocular deprivation on striate cortex cells in the cat
172 Citations1976Kenneth E. Kratz, P. D. Spear
Removal of the normal eye after the critical period in monocularly drprived kittens results in a rapid increase in the percent of striate cortex cells that can be driven by visual stimulation of the deprived eye, and there is no further increase in responsiveness over a period of more than a year.
Journal of NeuroscienceAn evaluation of the hypothesis of shifting terminals in goldfish optic tectum
167 Citations1984SS Easter, CA Stuermer
A detailed anatomical model of the terminal arbors of retinal ganglion cells continually shift positions in the optic tectum supports the hypothesis of shifting terminals in larval amphibians and teleost fish.
Behavioral and Neural BiologyThe function of dendritic spines: A review of theoretical issues
132 Citations1985Richard G. Coss, Donald H. Perkel
T theoretical findings are described that examine the effects of voltage-dependent inward-current channels in the spine head and their ability to amplify the charge transfer due to transmitter-dependent synaptic conductances.
ScienceAbnormal Development of Kitten Retino-Geniculate Connectivity in the Absence of Action Potentials
123 Citations1982Steven M. Archer, Mark W. Dubin +1 more
Lack of action potential activity in one eye of neonatal kittens was concluded to lead to abnormal development in the central nervous system.
Experimental Brain ResearchStatistical dependence between neighboring retinal ganglion cells in goldfish
121 Citations1978David W. Arnett
Simultaneous recordings were made of the spontaneous discharge of neighboring retinal ganglion cells in goldfish and crosscorrelation analysis indicates two types of correlation.
Brain ResearchA critical period for long-term potentiation in the developing rat visual cortex
117 Citations1988Amanda Perkins, Timothy J. Teyler
Experimental Brain ResearchCortical activity blockade prevents ocular dominance plasticity in the kitten visual cortex
107 Citations1986Holger O. Reiter, D.M. Waitzman +1 more
Previous work suggesting involvement of electrical activity at the level of the cortex in the phenomenon of cortical plasticity is extended by demonstrating an absolute requirement for discharge activities in the primary visual cortex.
The Journal of PhysiologyCross‐correlation analysis of the maintained discharge of rabbit retinal ganglion cells.
99 Citations1981D. Arnett, T E Spraker
Bipolar and photoreceptors are the most likely sources of noise responsible for the statistical dependency between retinal ganglion cells and the results are consistent with the hypothesis that a noise source provides shared input to two or more retinal gangs cells.
Journal of NeuroscienceAnatomy and physiology of experimentally produced striped tecta
94 Citations1981M I Law, Martha Constantine‐Paton
It is proposed that differential affinities between retinal and tecta loci which normally align the projection by bringing together appropriate pre- and postsynaptic areas and interactions among retinal ganglion cell fibers may be responsible for the afferent segregation found in diverse regions of many vertebrate brains.
NatureOcular dominance shift in kitten visual cortex caused by imbalance in retinal electrical activity
90 Citations1986Barbara Chapman, Michael D. Jacobson +2 more
It is indicated that patterned vision is not necessary for visual cortical plasticity, and that an imbalance in spontaneous retinal activity alone can produce a significant ocular dominance shift.
Experimental Brain ResearchCentral core control of developmental plasticity in the kitten visual cortex: II. Electrical activation of mesencephalic and diencephalic projections
88 Citations1982Wolf Singer, Josef P. Rauschecker
It is concluded that central core projections which modulate cortical excitability gate experience-dependent modifications of connections in the kitten visual cortex are responsible for ocular dominance changes.
Brain ResearchDiscontinuous mapping of retina onto tectum innervated by both eyes
88 Citations1975Robert L. Levine, Marcus Jacobson
Preliminary results are published because they allow us to reconsider the significance of results obtained when the optic nerve fibers from both eyes share the same tectal space.
Journal of NeuroscienceActivity and the formation of ocular dominance patches in dually innervated tectum of goldfish
86 Citations1984VC Boss, John T. Schmidt
The results support a hypothesis for an activity-dependent mechanism of segregation of ocular dominance patches in single tectal fish, and there was a significant tendency for high density areas in one projection to receive a lower density projection from the other eye, and vice versa.
PubMedEffects of 6-hydroxydopamine on visual deprivation in the kitten striate cortex.
75 Citations1983N. W. Daw, Ryan K. Rader +2 more
NatureDisruption of cortical activity prevents ocular dominance changes in monocularly deprived kittens
74 Citations1984C. Shaw, M. Cynader
It is reported that chronic intracortical administration of L-glutamate during a period of monocular vision imposed on young kittens largely prevents the ocular dominance shift which normally occurs under these circumstances.
Experimental Brain ResearchActions of excitatory amino acid antagonists on geniculo-cortical transmission in the cat's visual cortex
71 Citations1988Kenta M. Hagihara, Tadaharu Tsumoto +2 more
Previous suggestions that EAAs may be excitatory transmitters in the cerebral cortex, at least at geniculo-cortical synapses, are supported and indicate further that EAA receptors of the “non-NMDA type” may be involved in afferent synaptic transmission in the cat's visual cortex.
Journal of NeuroscienceEvidence for shifting connections during development of the chick retinotectal projection
65 Citations1985SC McLoon
Electron microscopic examination showed that at least some of the labeled axons in rostral tectum formed synapses with tectal cells by E7, and there is no delay between the time the retinal axons enter theTectum and the time they penetrate into synaptic layers of the tector, which shows two things which contrast with results from previous studies.
Journal of NeurosciencePharmacology of retinotectal transmission in the goldfish: effects of nicotinic ligands, strychnine, and kynurenic acid
61 Citations1987RB Langdon, JA Freeman
The failure of these cholinergic ligands to prevent postsynaptic responses indicates that excitatory retinotectal transmission does not depend on an intact nicotinic system, as previously proposed.
Journal of NeuroscienceDSP-4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine) depletes noradrenaline in kitten visual cortex without altering the effects of monocular deprivation
59 Citations1985N. W. Daw, TO Videen +2 more
It is concluded that depletion of cortical NA by itself does not prevent the cortical effects of monocular deprivation and that, where such an effect has been found, it may be due to some other factor.
NatureAbnormal visual input leads to development of abnormal axon trajectories in frogs
58 Citations1983Susan B. Udin
Anterograde horseradish peroxidase labelling of isthmo-tectal fibres is used to show the trajectories of such axons and to compare them with the routes which axons take when allowed to develop normally.
The Journal of Comparative NeurologyRole of visual experience in promoting segregation of eye dominance patches in the visual cortex of the cat
57 Citations1988Nicholas V. Swindale
Transneuronal autoradiography was used to study the role of visual experience in the development of ocular dominance patches in the cat and to assess quantitatively the effects of visual deprivation.
Proceedings of the Royal Society of London. Series B, Biological sciencesVisual deprivation and intertectal neuronal connexions in <i>Xenopus laevis</i>
50 Citations1975Michael J. Keating, Joan D. Feldman
It was concluded that visual function was necessary for the reorganization of intertectal connexions that follows larval eye rotation.
NatureCompound eyes project stripes on the optic tectum in Xenopus
50 Citations1982James W. Fawcett, David Willshaw
The observation that a single eye can produce a striped projection rules out many hypotheses of how stripes are formed, and provides evidence that the formation of an ordered projection on the optic tectum requires the operation of two separate mechanisms.
ScienceEye Dominance Columns from an Isogenic Double-Nasal Frog Eye
40 Citations1983Charles F. Ide, Scott E. Fraser +1 more
Electrophysiological and anatomical analyses showed that each of the two halves of this eye projected across the entire optic tectum in mirror image (double-nasal) fashion, and that fibers from each half-eye sorted out to form eye dominance stripes on the tectums.
Brain ResearchIntraocular injection of tetrodotoxin in goldfish decreases fast axonal transport of [3H]glucosamine-labeled materials in optic axons
35 Citations1984D. Louise Edwards, Bernice Grafstein
Brain Behavior and EvolutionDevelopment and Plasticity of Retinal X and Y Axon Terminations in the Cat's Lateral Geniculate Nucleus
30 Citations2008Mriganka Sur
These experiments suggest quite specific sequences and mechanisms for the development of individual X and Y retinogeniculate axons within the cat's lateral geniculate nucleus following a variety of manipulations that perturb normal development.
Brain ResearchLong-term potentiation in the goldfish optic tectum
25 Citations1986Deborah Lewis, Timothy J. Teyler
These results demonstrate a significant LTP with a slow time course and restricted low-frequency dependence in an in vitro goldfish optic tectum preparation.
NatureSpecificity of regenerating optic fibres for left and right optic tecta in goldfish
18 Citations1974J Cronly‐Dillon, B. Glaizner
This work has shown that during development the optic nerve fibres cross the midline and terminate on the opposite side where they “mirror” the topographical disposition of their retinal ganglion cells.
