2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a Neuroprotectant for Cerebral Ischemia
SciencePublished 2 February 1990
Malcolm J. Sheardown, Elsebet Ø. Nielsen, Anker Jón Hansen, Poul Jacobsen, Tage Honoré
Citations1,143
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
NBQX protects against global ischemia, even when administered 2 hours after an ischemic challenge, and is a potent and selective inhibitor of binding to the quisqualate subtype of the glutamate receptor, with no activity at the NMDA and glycine sites.
Abstract
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) is an analog of the quinoxalinedione antagonists to the non-N-methyl-D-aspartate (non-NMDA) glutamate receptor. NBQX is a potent and selective inhibitor of binding to the quisqualate subtype of the glutamate receptor, with no activity at the NMDA and glycine sites. NBQX protects against global ischemia, even when administered 2 hours after an ischemic challenge.
Keywords
ChemistryBiochemistry, Genetics and Molecular Biology
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