Ontologies for proteomics: towards a systematic definition of structure and function that scales to the genome level
Current Opinion in Chemical BiologyPublished 30 January 2003
Ning Lan, G.T. Montelione, Mark Gerstein
Citations52
SJR quartileQ1
SJR score2.06
SNIP1.23
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TL;DR
A principal aim of post-genomic biology is elucidating the structures, functions and biochemical properties of all gene products in a genome, but to adequately comprehend such a large amount of information the authors need new descriptions of proteins that scale to the genomic level, and a unified ontology for proteomics is needed.
Abstract
A principal aim of post-genomic biology is elucidating the structures, functions and biochemical properties of all gene products in a genome. However, to adequately comprehend such a large amount of information we need new descriptions of proteins that scale to the genomic level. In short, we need a unified ontology for proteomics. Much progress has been made towards this end, including a variety of approaches to systematic structural and functional classification and initial work towards developing standardized, unified descriptions for protein properties. In relation to function, there is a particularly great diversity of approaches, involving placing a protein in structured hierarchies or more-generalized networks and a recent approach based on circumscribing a protein's function through systematic enumeration of molecular interactions.
Keywords
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