Computer-aided Detection of Peripheral Lung Cancers Missed at CT: ROC Analyses without and with Localization
RadiologyPublished 1 November 2005
Li Feng, Hidetaka Arimura, Kenji Suzuki, Junji Shiraishi, Qiang Li, Hiroyuki Abé
Citations119
SJR quartileQ1
SJR score3.86
SNIP3.55
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Lung cancers missed at low-dose CT were very difficult to detect, even in an observer study, and the use of CAD can improve radiologists' performance in the detection of these subtle cancers.
Abstract
Lung cancers missed at low-dose CT were very difficult to detect, even in an observer study. The use of CAD, however, can improve radiologists' performance in the detection of these subtle cancers.
Keywords
Medicine
The LancetEarly Lung Cancer Action Project: overall design and findings from baseline screening
2,512 Citations1999Claudia I. Henschke, Dorothy I. McCauley +9 more
Low-dose CT can greatly improve the likelihood of detection of small non-calcified nodules, and thus of lung cancer at an earlier and potentially more curable stage, although false-positive CT results are common.
The LancetMass screening for lung cancer with mobile spiral computed tomography scanner
933 Citations1998Shusuke Sone, Shodayu Takashima +9 more
American Journal of RoentgenologyCT Screening for Lung Cancer
895 Citations2002Claudia I. Henschke, David F. Yankelevitz +4 more
In CT screening for lung cancer, the detected nodule commonly is either only part-solid or nonsolid, but such a nodule is more likely to be malignant than a solid one, even when nodule size is taken into account.
RadiologyPeripheral lung cancer: screening and detection with low-dose spiral CT versus radiography.
839 Citations1996Masahiro Kaneko, K. Eguchi +5 more
Low-dose spiral CT was superior to chest radiography in the screening and detection of peripheral lung cancer in high-risk individuals, and further large-scale studies are warranted, however, to clarify the efficacy and cost-effectiveness of low- dose spiral CT in a randomized, controlled population.
Statistics in MedicineMaximum likelihood estimation of receiver operating characteristic (ROC) curves from continuously-distributed data
786 Citations1998Charles E. Metz, B. Herman +1 more
Two new algorithms for fitting binormal ROC curves to continuously-distributed data are developed: a true ML algorithm (LABROC4) and a quasi-ML algorithm (LabROC5) that requires substantially less computation with large data sets.
American Journal of Respiratory and Critical Care MedicineScreening for Lung Cancer with Low-Dose Spiral Computed Tomography
687 Citations2002Stephen J. Swensen, James R. Jett +11 more
Investigative RadiologyReceiver Operating Characteristic Rating Analysis
654 Citations1992Donald D. Dorfman, Kevin S. Berbaum +1 more
RadiologyScreening for Early Lung Cancer with Low-Dose Spiral CT: Prevalence in 817 Asymptomatic Smokers
504 Citations2002Stefan Diederich, Dag Wormanns +5 more
Lung cancer screening with low-dose CT demonstrated a prevalence of asymptomatic cancers in 1.3% of a smoking population, including a high proportion of early tumor stages and a 20% rate of invasive procedures for benign lesions.
Investigative RadiologyImprovement in Radiologists?? Detection of Clustered Microcalcifications on Mammograms
361 Citations1990Heang‐Ping Chan, Kunio Doi +7 more
The results of the receiver operating characteristic (ROC) study show that CAD, as implemented by their computer code in its present state of development, does significantly improve radiologists' accuracy in detecting clustered microcalcifications under conditions that simulate the rapid interpretation of screening mammograms.
RadiologyCT Screening for Lung Cancer: Suspiciousness of Nodules according to Size on Baseline Scans
360 Citations2004Claudia I. Henschke, David F. Yankelevitz +7 more
In modern CT screening for lung cancer at baseline, detected noncalcified nodules smaller than 5.0 mm in diameter do not justify immediate work-up but only annual repeat screening to determine whether interim growth has occurred.
RadiologyLung Cancer: Performance of Automated Lung Nodule Detection Applied to Cancers Missed in a CT Screening Program
279 Citations2002Samuel G. Armato, Feng Li +4 more
Evaluating the performance of a fully automated computerized method for the detection of lung nodules in computed tomographic (CT) scans in the identification of lung cancers that may be missed during visual interpretation found it to be effective.
Journal of Mathematical Psychology“Proper” Binormal ROC Curves: Theory and Maximum-Likelihood Estimation
274 Citations1999Charles E. Metz, Xiaochuan Pan
RadiologyPulmonary Nodules at Chest CT: Effect of Computer-aided Diagnosis on Radiologists’ Detection Performance
273 Citations2004Kazuo Awai, Kohei Murao +5 more
Use of the CAD system improved the board-certified radiologists' and residents' detection of pulmonary nodules at chest CT and indicated a significant difference in Az values.
RadiologyMissed bronchogenic carcinoma: radiographic findings in 27 patients with a potentially resectable lesion evident in retrospect.
266 Citations1992John H. M. Austin, Benjamin Romney +1 more
The predominant characteristics of radiographically missed and potentially resectable bronchogenic carcinomas were difficulty in radiographic detection, female gender, and location in an upper lobe, especially on the right side.
Medical PhysicsMassive training artificial neural network (MTANN) for reduction of false positives in computerized detection of lung nodules in low‐dose computed tomography
264 Citations2003Kenji Suzuki, Samuel G. Armato +3 more
In this study, a pattern-recognition technique based on an artificial neural network (ANN), which is called a massive training artificial Neural network (MTANN), for reduction of false positives in computerized detection of lung nodules in low-dose computed tomography (CT) images is investigated.
RadiologyMalignant versus Benign Nodules at CT Screening for Lung Cancer: Comparison of Thin-Section CT Findings
249 Citations2004Feng Li, Shusuke Sone +3 more
Recognition of certain characteristics at thin-section CT can be helpful in differentiating small malignant nodules from benign nodules.
European Journal of RadiologyComputer-aided diagnosis in radiology: potential and pitfalls
229 Citations1999Kunio Doi, Heber MacMahon +3 more
A brief overview of some of CAD schemes for detection and differential diagnosis of pulmonary nodules and interstitial opacities in chest radiographs as well as clustered micro-calcifications and masses in mammograms is provided.
RadiologyVisual Detection and Localization of Radiographic Images
207 Citations1975Stuart J. Starr, Charles E. Metz +2 more
The authors describe and have confirmed experimentally a model which can be used to predict observer performance in an experiment requiring both detection and localization on the basis of the conventional ROC curve determined in a detection experiment.
RadiologyLung Cancers Missed at Low-Dose Helical CT Screening in a General Population: Comparison of Clinical, Histopathologic, and Imaging Findings
199 Citations2002Feng Li, Shusuke Sone +4 more
The lung cancers missed at low-dose CT screening in this series generally were very subtle and appeared as small faint nodules, overlapping normal structures, or opacities in a complex background of other disease.
American Journal of RoentgenologyLesion conspicuity, structured noise, and film reader error
149 Citations1976HL Kundel, George Révész
Preliminary results are presented which show that photographic subtraction can increase the conspicuity of simulated early lung lesions and improve their detection.
Academic RadiologyComputerized scheme for automated detection of lung nodules in low-dose computed tomography images for lung cancer screening1
147 Citations2004Hidetaka Arimura, Shigehiko Katsuragawa +5 more
American Journal of RoentgenologyImproved Detection of Lung Nodules on Chest Radiographs Using a Commercial Computer-Aided Diagnosis System
140 Citations2004Shingo Kakeda, Junji Moriya +8 more
This CAD system for digital chest radiographs can assist radiologists and has the potential to improve the detection of lung nodules due to lung cancer.
European RadiologyAutomatic detection of pulmonary nodules at spiral CT: clinical application of a computer-aided diagnosis system
136 Citations2001Dag Wormanns, Martin Fiebich +3 more
Computer-aided diagnosis improves detection of pulmonary nodules at spiral CT and is a valuable second opinion in a clinical setting for lung cancer screening despite of its still limited sensitivity.
RadiologyLung Micronodules: Automated Method for Detection at Thin-Section CT—Initial Experience
132 Citations2003Matthew S. Brown, Jonathan Goldin +4 more
An automated system for detecting lung micronodules on thin-section computed tomographic images and was applied to data from 15 subjects with 77 lung nodules considerably improved the radiologist's performance in micronodule detection.
RadiologyComputer-aided Diagnosis of Pulmonary Nodules: Results of a Large-Scale Observer Test
123 Citations1999Heber MacMahon, Roger Engelmann +6 more
CAD has the potential to improve diagnostic accuracy in the detection of lung nodules on digital radiographs and was significantly higher for all categories of observers when CAD was used.
RadiologyDetection Failures in Spiral CT Screening for Lung Cancer: Analysis of CT Findings
122 Citations1999Ryutaro Kakinuma, Hironobu Ohmatsu +7 more
RadiologySpiral CT of the chest: comparison of cine and film-based viewing.
105 Citations1995Steven E. Seltzer, Philip F. Judy +8 more
Cine viewing of spiral CT images of the chest improved radiologists' ability to detect nodules, and found a higher fraction of nodules with the cine presentation than with film.
RadiologyPrimary carcinoma of the lung overlooked at CT: analysis of findings in 14 patients.
96 Citations1996Charles S. White, Benjamin Romney +4 more
Endobronchial location and lower lobe predominance were the most common characteristics of overlooked lung cancer at CT and may have contributed to failure to diagnose the tumor.
RadiologyMissed lung cancer at CT: imaging findings in nine patients.
87 Citations1996J W Gurney
Small lung cancers that are near the threshold for detectability may be missed at CT, and failure of detection is attributable primarily to the poor conspicuity of lesions.
Academic RadiologyModel-based detection of lung nodules in computed tomography exams1
71 Citations2004Colin McCulloch, Robert Kaucic +3 more
A prototype model-based computer aided detection system designed to automatically detect both solid and subsolid pulmonary nodules in computed tomography (CT) images demonstrates promising results as a tool to improve the quality of radiologic readings by increasing radiologist sensitivity.
American Journal of RoentgenologyDetection of pulmonary nodules with helical CT: comparison of cine and film-based viewing.
53 Citations1997Manfred Tillich, Fritz Kammerhuber +4 more
Cine viewing of helical CT scans significantly increases the detection rate of pulmonary nodules that are smaller than or equal to 5 mm in diameter, however, it is found that there is no significant difference between cine and film-based viewing in the detection of pulmonary nodsules that were larger than 5mm in diameter.
