Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage
NeurologyPublished 24 April 2006
S. M. Davis, Joseph Broderick, M. Hennerici, Nikolai C. Brun, Michael N. Diringer, S. A. Mayer
Citations1,124
SJR quartileQ1
SJR score2.40
SNIP1.82
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TL;DR
Hematoma growth is an independent determinant of both mortality and functional outcome after intracerebral hemorrhage, and age, gender, location, blood glucose, and blood pressure did not predict outcomes.
Abstract
Hematoma growth is an independent determinant of both mortality and functional outcome after intracerebral hemorrhage. Attenuation of growth is an important therapeutic strategy.
Keywords
Medicine
New England Journal of MedicineTissue Plasminogen Activator for Acute Ischemic Stroke
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StrokeThe ICH Score
2,158 Citations2001J. Claude Hemphill, David C. Bonovich +3 more
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StrokeVolume of intracerebral hemorrhage. A powerful and easy-to-use predictor of 30-day mortality.
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Volume of intracerebral hemorrhage, in combination with the initial Glasgow Coma Scale score, is a powerful and easy-to-use predictor of 30-day mortality and morbidity in patients with spontaneous intrACEre cerebral hemorrhage.
New England Journal of MedicineSpontaneous Intracerebral Hemorrhage
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The LancetEarly surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial
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StrokeEarly Hemorrhage Growth in Patients With Intracerebral Hemorrhage
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Annals of NeurologyAcute hyperglycemia adversely affects stroke outcome: A magnetic resonance imaging and spectroscopy study
622 Citations2002Mark Parsons, P. Alan Barber +6 more
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StrokeEnlargement of Spontaneous Intracerebral Hemorrhage
572 Citations1996Seiji Kazui, Hiroaki Naritomi +3 more
Although expansion of intracerebral hemorrhage on CT scan was common in the hyperacute stage, 17% of hematoma expansion occurred even after 6 hours of onset, early CT scanning appears to increase the rate of detection of enlarging hematomas.
NeurologyEarly neurologic deterioration in intracerebral hemorrhage
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Clinical and biologic markers of the inflammatory reaction on admission are predictors of subsequent END, whereas early ICH growth, intraventricular bleeding, and high systolic blood pressure within 48 hours are factors associated with END in patients with spontaneous ICH.
StrokeMultivariate Analysis of Predictors of Hematoma Enlargement in Spontaneous Intracerebral Hemorrhage
388 Citations1998Yukihiko Fujii, Shigekazu Takeuchi +3 more
A particularly high likelihood of hematoma enlargement was observed in patients who were admitted shortly after onset, who were heavy drinkers; who had an irregularly shaped hematomas, whose consciousness was disturbed, and who had a low level of fibrinogen.
StrokeBlood Pressure Management in Acute Intracerebral Hemorrhage
377 Citations2004Kazuhiro Ohwaki, Eiji Yano +4 more
The findings suggest that elevated BP increases the risk of hematoma enlargement, and efforts to lower SBP below 150 mm Hg may prevent this risk.
StrokePredisposing Factors to Enlargement of Spontaneous Intracerebral Hematoma
372 Citations1997Seiji Kazui, Kazuo Minematsu +3 more
StrokeNatural History of Perihematomal Edema in Patients With Hyperacute Spontaneous Intracerebral Hemorrhage
259 Citations2002James Gebel, Edward C. Jauch +8 more
Perihematomal edema volume increases by approximately 75% during the first 24 hours after hyperacute spontaneous ICH, which is not significantly correlated with other clinical and radiological variables, including hematoma volume or change in hematomas volume.
NeurologyNeurologic deterioration in noncomatose patients with supratentorial intracerebral hemorrhage
259 Citations1994Stephan A. Mayer, Ralph L. Sacco +2 more
ND occurs in one-third of noncomatose patients with supratentorial ICH and carries a poor prognosis and large hematoma volume on CT, rather than clinical predictors, identifies patients at high risk for subsequent worsening.
Annals of NeurologyIntracerebral hemorrhage: External validation and extension of a model for prediction of 30‐day survival
256 Citations1991Stanley Tuhrim, James M. Dambrosia +5 more
Journal of neurosurgeryUltra-early evaluation of intracerebral hemorrhage
247 Citations1990Joseph P. Broderick, Thomas G. Brott +3 more
The data from this study indicate that, in ICH, bleeding may continue after the 1st hour post-hemorrhage, particularly in patients with early clinical deterioration.
StrokeMolecular Signatures of Vascular Injury Are Associated With Early Growth of Intracerebral Hemorrhage
242 Citations2004Yolanda Silva, Rogelio Leira +5 more
Molecular signatures of vascular injury and inflammatory markers in the early acute phase of ICH are associated with subsequent enlargement of the hematoma.
Annals of NeurologyPrediction of intracerebral hemorrhage survival
236 Citations1988Stanley Tuhrim, James M. Dambrosia +5 more
The Pilot Stroke Data Bank obtained information on 94 patients with intracerebral hemorrhage and a logistic regression model was derived, containing only Glasgow Coma Scale score, pulse pressure, and hemorrhage size, that could be used to categorize correctly 92% of the patients as alive or dead at 30 days after onset.
StrokeSafety and Feasibility of Recombinant Factor VIIa for Acute Intracerebral Hemorrhage
235 Citations2004Stephan A. Mayer, Nikolai C. Brun +5 more
This small phase II trial evaluated a wide range of rF VIIa doses in acute ICH and raised no major safety concerns, and larger studies are justified to determine whether rFVIIa can safely and effectively limit ICH growth.
NeurologyThe influence of diabetes and hyperglycemia on clinical course after intracerebral hemorrhage
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Both diabetes and admission hyperglycemia in nondiabetic patients are predictors of poor outcome after supratentorial ICH, and may be related to the greater incidence of cerebral and infectious complications in diabetic patients and of cerebral complications in hyperglycemic nondi diabetic patients.
Journal of Neurology Neurosurgery & PsychiatryAdmission blood glucose and short term survival in primary intracerebral haemorrhage: a population based study
218 Citations2005R Fogelholm
High admission blood glucose predicts increased 28 day case fatality rate in both nondiabetic and diabetic patients with ICH and is inclined to support the stress theory; high admissionBlood glucose is the result of a serious ICH.
StrokeUltra-Early Hemostatic Therapy for Intracerebral Hemorrhage
217 Citations2003Stephan A. Mayer
Ultra-early hemostatic therapy, given within 3 to 4 hours of onset, may potentially arrest ongoing bleeding and minimize hematoma growth after ICH.
Journal of neurosurgeryPrediction of death in patients with primary intracerebral hemorrhage: a prospective study of a defined population
212 Citations2002Ola Nilsson, Arne Lindgren +2 more
Primary ICH remains a stroke subtype associated with a high mortality rate and for which the level of consciousness on admission is the strongest predictor of fatal outcome both at 30 days and during the 1st year after bleeding.
Journal of Neurology Neurosurgery & PsychiatryPrognostic factors in patients with intracerebral haematoma.
212 Citations1992C L Franke, John C. van Swieten +2 more
NeurosurgeryMultimodality Treatment of Giant Intracranial Arteriovenous Malformations
210 Citations2003Steven D. Chang, Mary L. Marcellus +4 more
The results in this series of patients with giant AVMs, which represents the largest series reported to date, suggest that selected symptomatic patients with Giant AVMs can be treated successfully with good outcomes and acceptable risk.
StrokeExtravasation of Radiographic Contrast Is an Independent Predictor of Death in Primary Intracerebral Hemorrhage
206 Citations1999Kyra J. Becker, Alexander Baxter +4 more
If contrast extravasation represents ongoing hemorrhage, the findings in this study may have implications for therapy of ICH, particularly with regard to blood pressure management.
Journal of Neurology Neurosurgery & PsychiatryIntracerebral haemorrhage: a model for the prediction of outcome.
198 Citations1987Russell K. Portenoy, Richard B. Lipton +3 more
A model was developed which accurately estimates the probability of good outcome and the risk of poor outcome based on data available on presentation and may be useful in choosing patients for surgical evacuation of haematomas.
StrokePerihematomal Edema in Primary Intracerebral Hemorrhage Is Plasma Derived
195 Citations2004Kenneth Butcher, Tracey Baird +4 more
Increased rates of water diffusion in the perihematomal region independently predict edema volume, suggesting the latter is plasma derived.
Journal of Neurology Neurosurgery & PsychiatryPredictors of good outcome in medium to large spontaneous supratentorial intracerebral haemorrhages
126 Citations2005Mar Castellanos
Good outcome in medium to large ICH can be predicted on admission by three readily assessable factors (CSS score, ICH location, and fibrinogen levels).
NeurologyProgression of hypertensive intracerebral hemorrhage
124 Citations1989S. T. Chen, Shang‐Der Chen +2 more
Serial studies indicate that active bleeding or rebleeding can occur in HICH and suggests that the risk is particularly high with thalamic hemorrhage and concludes that meticulous control of hypertension after HICH may be justified in selected patients.
StrokeThe prognostic value of the CT scan in conservatively treated patients with intracerebral hematoma.
90 Citations1984Israel Steiner, John M. Gomori +1 more
The data indicates a favourable outcome in a relatively large percentage of patients with ICH treated conservatively and therefore questions the need for surgical evacuation of hematoma.
Neurocritical CareRecombinant Activated Factor VII for Acute Intracerebral Hemorrhage: US Phase IIA Trial
81 Citations2006Stephan A. Mayer, Nikolai C. Brun +5 more
Ultra-early rF VIIa treatment for ICH was associated with a reasonable safety profile in this preliminary study across a wide range of dosages, and further research is warranted to investigate the safety and potential efficacy of rFVIIa for minimizing ICH growth.
Journal of neurosurgeryThree-dimensional computerized tomography angiography in patients with hyperacute intracerebral hemorrhage
77 Citations1999Yasuo Murai, Ryo Takagi +3 more
3D-CT angiography was found to be valuable in the diagnosis of the cause of hemorrhage and in the detection of persistent hemorrhage in patients with acute ICH.
NeurosurgeryIntracranial Pressure Time Course in Primary Intracerebral Hemorrhage
70 Citations1979Isacco Papo, P Janny +3 more
The course of intracranial pressure (ICP) over time was studied in 66 hypertensive and/or altherosclerotic patients harboring intracerebral hematomas and no definite correlation was found between ICP, clinical condition, and outcome.
NeurologyActive bleeding in hypertensive intracerebral hemorrhage
62 Citations1982Roger E. Kelley, Joseph Berger +2 more
Four patients with spontaneous intracerebral hemorrhage were observed to have evidence of active bleeding when CT was performed within 6 hours of onset, and three hemorrhages were thalamic, and one was in the basal ganglia.
Archives of NeurologyHypertensive Intracerebral Hematoma
62 Citations1974Diego J. Herbstein
In two nonhypertensive patients, intracerebral hematomas secondary to a ruptured berry aneurysm and an arteriovenous malformation contained high levels of radioisotopic activity, suggesting a different pathophysiology of bleeding.
StrokeGavestinel Does Not Improve Outcome After Acute Intracerebral Hemorrhage
60 Citations2005E. Clarke Haley, John L.P. Thompson +8 more
The combined GAIN International and GAIN Americas trials suggest that gavestinel is not of substantial benefit or harm to patients with primary intracerebral hemorrhage, similar to results previously reported in patients with ischemic stroke.
StrokeArteriographically Visualized Extravasation in Hypertensive Intracerebral Hemorrhage
49 Citations1972Masahiro Mizukami, Goro Araki +3 more
The theory that continuous bleeding from the ruptured artery with mechanical destruction and displacement of cerebral tissue is the cause of massive hematoma formation is advanced and the possibility of surgical treatment of the acute stage of hypertensive intracerebral hemorrhage is discussed.
Journal of neurosurgeryExtravasation of angiographic contrast material in hypertensive intracerebral hemorrhage
28 Citations1972Masayoshi Kowada, Koichi Yamaguchi +2 more
Leakage of contrast material during angiography is an uncommon phenomenon in hypertensive intracerebral hemorrhage and three of the four patients in whom the hematoma was evacuated surgically showed clinical improvement.
