CHARACTERIZATION OF CULTURED BLADDER SMOOTH MUSCLE CELLS: ASSESSMENT OF IN VITRO CONTRACTILITY
The Journal of UrologyPublished 1 November 1999
Bradley P. Kropp, Yuanyuan Zhang, James J. Tomasek, Rick Cowan, PETER D. FURNESS, Melville B. Vaughan
Citations74
SJR quartileQ1
SJR score2.21
SNIP2.70
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TL;DR
In vitro cultured bladder SMC demonstrate loss of contractile response to normal in vivo pharmacologic agonists, and can be distinguished in vitro from fibroblasts based upon their lack of contractiles response to calcium- ionophore.
Abstract
In vitro cultured bladder SMC demonstrate loss of contractile response to normal in vivo pharmacologic agonists. Both human and rat bladder SMC can be distinguished in vitro from fibroblasts based upon their lack of contractile response to calcium- ionophore. These results demonstrate the ability to further characterize cultured bladder SMC with in vitro contractility. Further characterization is essential if we are to advance our understanding of the clinical applicability of in vitro studies utilizing cultured bladder SMC.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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