A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family
NaturePublished 1 April 1986
Peter Besmer, John E. Murphy, Patricia C. George, Feihua Qiu, Peter J. Bergold, Lynn Lederman
Citations641
SJR quartileQ1
SJR score18.29
SNIP10.16
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TL;DR
A new acute transforming feline retrovirus, the Hardy-Zuckerman 4 feline sarcoma virus (HZ4-FeSV), has been isolated from a feline fibrosarcoma.
Abstract
A new acute transforming feline retrovirus, the Hardy-Zuckerman 4 feline sarcoma virus (HZ4-FeSV), has been isolated from a feline fibrosarcoma. The viral genome of HZ4-FeSV contains a new oncogene designated v-kit, has the structure 5' delta gag-kit-delta pol-delta env 3' and specifies a gag-kit polyprotein of relative molecular mass 80,000. The predicted kit amino-acid sequence displays partial homology with tyrosine-specific protein kinase oncogenes. HZ4-FeSV appears to have been generated by transduction of feline c-kit sequences with feline leukaemia virus.
Keywords
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