Effect of Vitamin E and Beta Carotene on the Incidence of Angina Pectoris
JAMAPublished 6 March 1996
J Rapola
Citations215
SJR quartileQ1
SJR score5.35
SNIP10.71
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Abstract
Supplementation with alpha tocopherol was associated with only a minor decrease in the incidence of angina pectoris. Beta carotene had no preventive effect and was associated with a slight increase of angina.
Keywords
MedicineNursing
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All CHD-suggestive criteria had approximately the same diagnostic performance regardless of age, i.e., approximately one false positive/two true positives.
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174 Citations1993Eric Chatelain, Daniel Boscoboinik +5 more
In the case of alpha-tocopherol the antiproliferative effect was found to be parallel to the inhibition of protein kinase C activity, as measured in streptolysin-O permeabilized cells.
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171 Citations1989Derek G. Cook, A. G. Shaper +1 more
In cardiovascular studies of middle-aged men which use the WHO (Rose) questionnaire for the purposes of determining prevalence or assessing risk of a heart attack, angina should include both 'possible' and 'definite' angina.
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In vivo β-carotene supplementation may lead to a shortening of the lag phase of Cu 2+ -induced lipid peroxidation in LDL, indicating that the protection of LDL against metal ion-dependent and -independent oxidation is not enhanced.
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Dietary alpha-tocopherol may provide at least as good an explanation as does wine for the paradoxically low rates of CHD in several European countries which have a relatively high saturated fatty acid intake.
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A generally poor relationship between Rose Questionnaire angina and thallium-201 scintigraphy, an objective measure of myocardial ischemia in patients with chest pain referred for clinical exercise testing, is indicated.
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The effects of feeding lower doses of beta-carotene on the susceptibility of LDL to oxidation are reported and whether any antioxidant activity of Beta-Carotene can be detected when different modes of initiating oxidation are used are tested.
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34 Citations1974T.W. Anderson
The claim that the symptoms of angina pectoris can usually be relieved by large doses of vitamin E has been reinvestigated by means of a randomized double-blind trial, which yielded statistically convincing evidence that vitamin E is of value in the treatment ofAngina.
Journal of Epidemiology & Community HealthPredicting coronary heart disease from minor symptoms and electrocardiographic findings.
32 Citations1971G Rose
The present study estimates the frequency with which minor symptoms and electro cardiographic changes may occur in the years before these major 'unexpected' illnesses.
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14 Citations1972T Zeiner-Henriksen
Reinterviews confined to the ‘Cardiac pain questionnaire’ were conducted on 237 middle-aged men in Oslo, interviewed about 10 months previously in connection with a Finnish-Norwegian lung cancer study, and high rates of conversion to negatives at the reinterview were observed.
