Polygenic Risk and the Developmental Progression to Heavy, Persistent Smoking and Nicotine Dependence
JAMA PsychiatryPublished 27 March 2013
Daniel W. Belsky, Terrie E. Moffitt, Timothy B. Baker, Andrea K. Biddle, James P. Evans, Hona Lee Harrington
Citations151
SJR quartileQ1
SJR score5.75
SNIP4.92
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TL;DR
To test how genetic risks discovered in genome-wide association studies of adult smoking influence the developmental progression of smoking behavior from initiation through conversion to daily smoking, progression to heavy smoking, nicotine dependence, and struggles with cessation, a 38-year, prospective, longitudinal study of a representative birth cohort is conducted.
Abstract
Initiatives that disrupt the developmental progression of smoking behavior among adolescents may mitigate genetic risks for developing adult smoking problems. Future genetic research may maximize discovery potential by focusing on smoking behavior soon after smoking initiation and by studying young smokers.
Keywords
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32,712 Citations2008Kristopher J. Preacher, Andrew F. Hayes
An overview of simple and multiple mediation is provided and three approaches that can be used to investigate indirect processes, as well as methods for contrasting two or more mediators within a single model are explored.
British Journal of AddictionThe Fagerström Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire
10,770 Citations1991Todd F. Heatherton, Lynn T. Kozlowski +2 more
A revision of the FTQ: the Fagerström Test for Nicotine Dependence (FTND), which found that a revised scoring of time to the first cigarette of the day (TTF) and number of cigarettes smoked per day (CPD) improved the scale.
BiometricsModels for Longitudinal Data: A Generalized Estimating Equation Approach
4,532 Citations1988Scott L. Zeger, Kung‐Yee Liang +1 more
This article discusses extensions of generalized linear models for the analysis of longitudinal data in which heterogeneity in regression parameters is explicitly modelled and uses a generalized estimating equation approach to fit both classes of models for discrete and continuous outcomes.
International Journal of EpidemiologySick individuals and sick populations
3,653 Citations2001Geoffrey Rose
Aetiology confronts two distinct issues: the determinant of individual cases, and the determinants of incidence rate: if exposure to a necessary agent is homogeneous within a population, then case/control and cohort methods will fail to detect it.
Psychological MethodsEffect size measures for mediation models: Quantitative strategies for communicating indirect effects.
2,993 Citations2011Kristopher J. Preacher, Ken Kelley
The first new effect size index is described is a residual-based index that quantifies the amount of variance explained in both the mediator and the outcome and the second new effectsize index quantifying the indirect effect as the proportion of the maximum possible indirect effect that could have been obtained, given the scales of the variables involved.
International Journal of EpidemiologySick Individuals and Sick Populations
2,610 Citations1985Geoffrey Rose
Empirical research into the causes and mechanisms of illness is often defined in terms of study of the determinants of the distribution of the disease; but the authors should not forget that the more widespread is a particular cause, the less it explains the Distribution of cases.
Addictive BehaviorsMeasuring degree of physical dependence to tobacco smoking with reference to individualization of treatment
2,224 Citations1978Karl‐Olov Fagerström
American Journal of EpidemiologyEstimating the Relative Risk in Cohort Studies and Clinical Trials of Common Outcomes
2,070 Citations2003Louise‐Anne McNutt
The purpose of this paper is to discuss the incorrect application of a proposed method to estimate an adjusted relative risk from an adjusted odds ratio, which has quickly gained popularity in medical and public health research, and to describe alternative statistical methods for estimating anadjusted relative risk when the outcome is common.
Evaluation ReviewEstimating Mediated Effects in Prevention Studies
1,967 Citations1993David P. MacKinnon, James H. Dwyer
Assessment of how prevention and intervention programs achieve their effects requires the measurement of intervening or mediating variables hypothesized to represent the causal mechanism by which the prevention program achieves its effects.
Psychological BulletinRegression analyses of counts and rates: Poisson, overdispersed Poisson, and negative binomial models.
1,778 Citations1995William Gardner, Edward P. Mulvey +1 more
New England Journal of MedicineNicotine Addiction
1,424 Citations2010Neal L. Benowitz
From the Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center; and the Departments of Medicine, Bioengineering and Therapeutic Sciences, University of California, San SF — both in San Francisco.
Yearbook of MedicineAnnual Smoking-Attributable Mortality, Years of Potential Life Lost, and Productivity Losses—United States, 1997–2001
1,422 Citations2007L.T. Tanoue
BiometrikaOn the regression analysis of multivariate failure time data
1,321 Citations1981Ross L. Prentice, Brandon Williams +1 more
DECP DebateSex Differences in Antisocial Behaviour Conduct Disorder, Delinquency, and Violence in the Dunedin Longitudinal Study
1,216 Citations2009Terrie E. Moffitt, Avshalom Caspi +2 more
The recommendation to relax the criteria for diagnosing conduct disorder in girls and the effects of antisocial behaviour on young adult outcomes is evaluated.
Nature GeneticsGenome-wide meta-analyses identify multiple loci associated with smoking behavior
1,159 Citations2010Yunjung Kim, Patrick F Sullivan +153 more
A meta-analyses of several smoking phenotypes within cohorts of the Tobacco and Genetics Consortium found the strongest association was a synonymous 15q25 SNP in the nicotinic receptor gene CHRNA3, and three loci associated with number of cigarettes smoked per day were identified.
The LancetAssociation between children's experience of socioeconomic disadvantage and adult health: a life-course study
1,008 Citations2002Richie Poulton, Avshalom Caspi +5 more
JAMASmoking-Attributable Mortality, Years of Potential Life Lost, and Productivity Losses—United States, 2000-2004
953 Citations2009
The updated analysis indicated that, during 2000-2004, cigarette smoking and exposure to tobacco smoke resulted in at least 443,000 premature deaths, approximately 5.1 million YPLL, and $96.8 billion in productivity losses annually in the United States.
Understanding StatisticsRepairing Tom Swift's Electric Factor Analysis Machine
857 Citations2003Kristopher J. Preacher, Robert C. MacCallum
Human Molecular GeneticsCholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs
845 Citations2006Scott F. Saccone, Anthony L. Hinrichs +20 more
This study represents one of the most powerful and extensive studies of nicotine dependence to date and has found novel risk loci that require confirmation by replication studies.
Nature GeneticsSequence variants at CHRNB3–CHRNA6 and CYP2A6 affect smoking behavior
695 Citations2010Thorgeir E. Thorgeirsson, Daníel F. Guðbjartsson +92 more
Among the genes at the two newly associated loci are genes encoding nicotine-metabolizing enzymes (CYP2A6 and CYP2B6) and nicotinic acetylcholine receptor subunits (CHRNB3 and CHRNA6), all of which have been highlighted in previous studies of smoking and nicotine dependence.
American Journal of Public HealthSmoking cessation in young adults: age at initiation of cigarette smoking and other suspected influences.
689 Citations1996Naomi Breslau, Edward L. Peterson
Public policy to discourage early smoking, if it succeeds in delaying the initiation of smoking, might contribute to the reduction of smoking-related mortality and morbidity by increasing the potential for quitting.
Nature Reviews GeneticsCommon disorders are quantitative traits
684 Citations2009Robert Plomin, Claire M. A. Haworth +1 more
A polygenic framework is highlighted, supported by recent GWA research, in which qualitative disorders can be interpreted simply as being the extremes of quantitative dimensions, which has far-reaching implications for the diagnosis, treatment and prevention of the problematic extremes of these traits.
Human Molecular GeneticsNovel genes identified in a high-density genome wide association study for nicotine dependence
625 Citations2006Laura J. Bierut, Pamela A. F. Madden +20 more
This study nominates several novel genes, such as Neurexin 1 (NRXN1), in the development of nicotine dependence while also identifying a known candidate gene, the beta3 nicotinic cholinergic receptor.
Nature GeneticsMeta-analysis and imputation refines the association of 15q25 with smoking quantity
618 Citations2010Jason Z. Liu, Federica Tozzi +104 more
TheOx-GSK study established to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits confirmed an effect on smoking quantity at a locus on 15q25 that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits.
Epidemiologic ReviewsThe Social Epidemiology of Substance Use
542 Citations2004Sandro Galea
Tobacco, alcohol, and illicit substance use continue to result in substantial morbidity and mortality and significant societal economic costs despite considerable efforts to minimize use of licit substances and prevent use of illicit substances.
Nicotine & Tobacco ResearchThe genetic epidemiology of smoking
467 Citations1999Patrick Sullivan, Kenneth S. Kendler
PLoS GeneticsMultiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD
397 Citations2010Nancy L. Saccone, Robert Culverhouse +61 more
This study provides strong evidence that multiple statistically distinct loci in this region affect smoking behavior, and is the first report of association between rs588765 (and correlates) and smoking that achieves genome-wide significance.
International Journal of EpidemiologyEpidemiology, epigenetics and the ‘Gloomy Prospect’: embracing randomness in population health research and practice
345 Citations2011George Davey Smith
Several lines of evidence suggest that epidemiological approaches will remain fruitful as the authors enter the decade of the epigenome, where the basic notion that what is near-random at one level may be almost entirely predictable at a higher level is an emergent property of many systems.
Biological PsychiatrySpurious Genetic Associations
337 Citations2007Patrick F. Sullivan
This work explored the capacity of association studies to produce false positive findings and the impact of various definitions of replication, and found findings from single association studies constitute "tentative knowledge" and must be interpreted with exceptional caution.
Nature Reviews GeneticsEducating health-care professionals about genetics and genomics
299 Citations2007Alan E. Guttmacher, Mary Porteous +1 more
For genomics to have an effect on clinical practice that is comparable to its impact on research will require advances in the genomic literacy of health-care providers.
PsychopharmacologyTobacco ?chippers? ?individual differences in tobacco dependence
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Tobacco “chippers”' smoking behavior challenges classical theories of dependence; further research is needed on the factors that may protect CHs from addiction.
PLoS GeneticsA Candidate Gene Approach Identifies the CHRNA5-A3-B4 Region as a Risk Factor for Age-Dependent Nicotine Addiction
270 Citations2008Robert B. Weiss, Timothy B. Baker +17 more
A strong mechanistic link among early nicotine exposure, common CHRNA5-A3-B4 haplotypes, and adult nicotine addiction in three independent populations of European origins is established and reinforces the importance of preventing early exposure to tobacco through public health policies.
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263 Citations2005Viba Malaiyandi, Edward M. Sellers +1 more
Some of the recent findings on the influence of CYP2A6 genetic polymorphisms on nicotine kinetics, smoking behaviors, and how the gene appears to exert differential effects during various stages of smoking are reviewed.
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With global funding for genomics approaching $3 billion/year, it seems an appropriate time to take stock of whence the real benefits from genomic research may come and how best to attain a future in which genomics improves human health.
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The predictive significance of the initial smoking experience and parental dependence highlight the potential importance of genetic factors in the etiology of nicotine dependence.
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Genetic studies to date have been most successful at identifying genetic factors that influence the transition from regular use to dependence and the conversion from experimental use to established use before development of dependence.
JNCI Journal of the National Cancer InstituteRelationship Between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 Variation and Smoking Behaviors and Lung Cancer Risk
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140 Citations2011
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138 Citations2003Hong Xian, Jeffrey F. Scherrer +5 more
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89 Citations2011Anne M. Joseph
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Nicotine & Tobacco ResearchAnalysis of Detailed Phenotype Profiles Reveals CHRNA5-CHRNA3-CHRNB4 Gene Cluster Association With Several Nicotine Dependence Traits
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