Olfactory Genetics and Anosmia
Handbook of sensory physiologyPublished 1 January 1971
John E. Amoore
Citations49
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TL;DR
There is an enormous variation among the human population as regards olfactory acuity, and approximately 95% of the population should have personal thresholds between 1/10 th.
Abstract
There is an enormous variation among the human population as regards olfactory acuity. Even persons with no obvious abnormality may range in sensitivity as much as 1,000-fold between the least and the most sensitive observers (Amoore, 1968b). More precisely, the standard deviation (SD) from the mean olfactory sensitivity in a sample of 443 subjects toward isobutyl isobutyrate was ± 1.71 binary dilution steps in a geometric concentration scale. Hence, taking the normal mean detection threshold as unity, approximately 95% of the population should have personal thresholds between 1/10 th. and 10 times the mean threshold concentration for a given odorant.
Keywords
ChemistryNeuroscience
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The fact that some people cannot detect the odour of isobutyric acid even though their sense of smell may be otherwise complete suggests that this substance, or a substance with molecules which are similar in size, shape and functional group, may represent a primary odour.
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