Recombinant interleukin 2 (IL-2) promotes T cell line-mediated neuroautoimmune disease
Journal of NeuroimmunologyPublished 1 March 1986
Hermann J. Schluesener, Hans Lassmann
Citations12
SJR quartileQ2
SJR score0.90
SNIP0.71
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TL;DR
Using a T cell transfer model of autoimmune central nervous system (CNS) disease, it is observed that recombinant IL-2 strongly promotes autoimmune disease.
Abstract
Autoimmunity is dependent on a delicate balance of cellular interactions preventing activation of autoaggressive T cells. Possible side effects of therapeutically injected recombinant interleukins on latent or overt autoimmune disease are uncertain. Using a T cell transfer model of autoimmune central nervous system (CNS) disease, we investigated the in vivo effect of recombinant IL-2. We observed that recombinant IL-2 strongly promotes autoimmune disease.
Keywords
Immunology and MicrobiologyMedicineNeuroscience
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