Staging and survival of colorectal cancer: are we making progress? The 14-year experience of a specialized cancer registry
Digestive and Liver DiseasePublished 1 May 2000
Maurizio Ponz de Leòn
Citations22
SJR quartileQ1
SJR score1.09
SNIP0.87
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
In Northern Italy, incidence rates of colorectal carcinoma are rising and this trend is associated with a sharp increase of newly detected localized lesions and with a significant improvement of overall 5-year survival.
Abstract
In Northern Italy, incidence rates of colorectal carcinoma are rising. This trend is associated with a sharp increase of newly detected localized lesions and with a significant improvement of overall 5-year survival. The result may be attributed to several concomitant factors, such as: A] wider use of colonoscopy, B) increased education of patients, C) more attention given to symptoms.
Keywords
Medicine
Springer series in statisticsNonparametric Estimation from Incomplete Observations
45,533 Citations1992Edward L. Kaplan, Paul Meier
British Journal of CancerDesign and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples
8,392 Citations1977Richard Peto, M. C. Pike +8 more
Efficient methods of analysis of randomized clinical trials in which the authors wish to compare the duration of survival among different groups of patients are described.
The LancetRandomised study of screening for colorectal cancer with faecal-occult-blood test
2,487 Citations1996O Kronbörg, Claus Fenger +3 more
The findings indicate that biennial screening by FOB tests can reduce CRC mortality, and the effect of the removal of more precursor adenomas in the screening-group participants than in controls on CRC incidence.
NatureMutations of two P/WS homologues in hereditary nonpolyposis colon cancer
1,540 Citations1994Nicholas C. Nicolaides, Nickolas Papadopoulos +16 more
Two additional homologues of the prokaryotic mutL gene were found to be mutated in the germline of HNPCC patients, which doubles the number of genes implicated in H NPCC and may help explain the relatively high incidence of this disease.
ScienceGenetic Mapping of a Locus Predisposing to Human Colorectal Cancer
933 Citations1993Païvi Peltomäki, Lauri A. Aaltonen +12 more
Results prove the existence of a genetically determined predisposition to colorectal cancer that has important ramifications for understanding and preventing this disease.
New England Journal of MedicineProgress against Cancer?
410 Citations1986John C. Bailar, Elaine Smith
According to this measure, the United States is losing the war against cancer, notwithstanding progress against several uncommon forms of the disease, improvements in palliation, and extension of the productive years of life.
Cancer Genetics and CytogeneticsAn update of HNPCC (Lynch syndrome)
223 Citations1997Henry T. Lynch, Thomas C. Smyrk +1 more
HNPCC's differential diagnosis, heterogeneity, tumor spectrum, newly found evidence of accelerated colonic adenoma to CRC, survival advantage, and currently available surveillance and management programs are reviewed.
International Journal of CancerOverview of natural history, pathology, molecular genetics and management of HNPCC (Lynch syndrome)
202 Citations1996Henry T. Lynch, Thomas C. Smyrk +1 more
New findings in the pathology of HNPCC, particularly an increased frequency of interval cancers and the likely accelerated rate of the adenoma to cancer sequence, indicate the need for more frequent colonoscopic surveillance with an option for prophylactic subtotal colectomy in germ‐line‐positive individuals.
PubMedFamilial aggregation of tumors in the three-year experience of a population-based colorectal cancer registry.
127 Citations1989Maurizio Ponz de Leòn, Romano Sassatelli +4 more
It is suggested that in approximately 15-20% of patients registered for colorectal cancer one or more first-degree relatives are affected by neoplasms of the large bowel, which strongly suggests a genetic susceptibility to coloreCTal cancer in a fraction of these patients.
CancerIdentification of hereditary nonpolyposis colorectal cancer in the general population. The 6-year experience of a population-based registry
119 Citations1993Maurizio Ponz de Leòn, Romano Sassatelli +2 more
HNPCC is an autosomal dominant disease characterized by early‐onset intestinal neoplasms, localization of tumors in the proximal colon, and frequent association with cancers at other sites, especially the endometrium, skin, and stomach.
GastroenterologyColorectal cancer screening: Recommendations of the U.S. Preventive Services Task Force
79 Citations1996Bernard Levin, John H. Bond
CancerGIVIO-SITAC 01
64 Citations1998Alberto Zaniboni, Roberto Labianca +8 more
This report is to update the survival data for patients enrolled in the trial and describe their reported perceptions of their own health and quality of life.
Tumori JournalVariations in the Survival of Adult Cancer Patients in Italy
38 Citations1997Gemma Gatta, Eva Buiatti +8 more
The present study analyzed and compared population-based data on the survival of adult cancer patients in Italy, according to sex, age, period of diagnosis and geographical area, to find that there was a general improvement in 5-year relative survival and that women have a better prognosis for most cancer sites.
European Journal of CancerDescriptive epidemiology of colorectal cancer in Italy: The 6-year experience of a specialised registry
36 Citations1993Maurizio Ponz de Leòn, Romano Sassatelli +7 more
This study confirms previously reported data about incidence and mortality rates for colorectal cancer in northern Italy and confirms that the clinical outcome of this neoplasm remains unfavourable in more than 50% of the affected patients.
British Journal of CancerThe effect of family size on estimates of the frequency of hereditary non-polyposis colorectal cancer
28 Citations1995Antonio Percesepe, M. Anti +7 more
Logistic regression showed a significant association for family size with the Amsterdam-criteria-based HNPCC diagnosis, and linear discriminant analysis showed that H NPCC diagnosis was most likely to occur when first-degree pedigrees contained more than seven relatives.
Annals of SurgerySurvival After Colon Cancer 1973-1990 in Sweden
26 Citations1997Paul Blomqvist, Anders Ekbom +4 more
Although survival in patients with colon cancer improved and convergence between different catchment area categories was seen, a large initial gap as well as a remaining difference may warrant future monitoring to ensure equal prognosis, irrespective of domicile.
British journal of surgeryAdjuvant therapy for resectable rectal and colonic cancer
25 Citations1998Alexander G. Heriot, Dinesh Kumar
Recurrence of rectal and colonic cancer remains substantial despite apparently curative surgery and adjuvant therapy has been applied to improve prognosis.
PubMedEpidemiology of cancer of the large bowel--the 12-year experience of a specialized registry in northern Italy.
24 Citations1999Maurizio Ponz de Leòn, Piero Benatti +7 more
The research provided an updated description of the main findings (in particular, incidence, staging, morphology and survival) observed in the 12-year registration period of colorectal cancer in Italy.
International Journal of CancerRisk of cancer revealed by follow‐up of families with hereditary non‐polyposis colorectal cancer: A population‐based study
22 Citations1993Maurizio Ponz de Leòn, Piero Benatti +3 more
HNPCC family members are at increased risk of developing colorectal cancer, with an earlier onset than the general population; in contrast, high‐risk individuals in “suspected” HNPCC families seem to be prone to a broader neoplastic spectrum, and risk of tumours does not seem to been limited to any particular age‐group.
Journal of Clinical EpidemiologyA marked increase in the incidence of colorectal cancer over two decades in southwest Finland
20 Citations1997Matti Kemppainen, Ismo Räihä +1 more
There was an increase in colon cancer mortality while the mortality of rectal cancer cancer slightly decreased, and there was no change in the spread and operability of colorectal cancers during the two decades.
Tumori JournalEvaluation of Clinical Efficacy of New Medical Treatments in Advanced Colorectal Cancer. Results of a Workshop Organized by the Eortc Gitccg
19 Citations1998J. Wils, Tarek Sahmoud +28 more
A workshop with experts from different countries and national groups to discuss in depth several aspects concerning the treatment of patients with advanced colorectal cancer.
European Journal of CancerClinical features, frequency and prognosis of Dukes' A colorectal carcinoma: A population-based investigation
13 Citations1996Carmela Di Gregorio, Rossella Fante +8 more
Dukes' A carcinomas associated with a poor prognosis did not show any of the biological variables usually associated with an unfavourable outcome, but, the data suggest the possibility of incomplete removal of tumours at surgery.