CHANGES IN INSULIN RESPONSIVENESS DURING DEVELOPMENT OF MAMMARY EPITHELIUM
The Journal of Cell BiologyPublished 1 August 1974Open access
Takami Oka, John W. Perry, Yale J. Topper
Citations49
SJR quartileQ1
SJR score3.36
SNIP1.52
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Responsiveness to the hormone changes in the various physiological states is shown in a manner consistent with the view that these changes may be key factors in control of mammary gland development.
Keywords
Environmental Science
Experimental Cell ResearchDNA synthesis and myogenesis
555 Citations1961Frank E. Stockdale, Howard Holtzer
Differentiating muscle cells synthesizing myosin, the meromyosins, and actin do not concurrently synthesize DNA, and the multinucleated skeletal muscle fiber is the product of cell fusion.
Biochemical JournalLevels of enzymes of the direct oxidative pathway of carbohydrate metabolism in mammalian tissues and tumours
439 Citations1954Gertrude E. Glock, Patricia McLean
The enzyme activity levels in these consecutive stages of the direct oxidative pathway have been determined in a variety of normal mammalian tissues and tumours and are reported in the present paper.
EndocrinologySerum Prolactin Levels in Rats During Different Reproductive States
400 Citations1970YOSHIHIKO AMENOMORI, C. L. Chen +1 more
Rat serum prolactin as determined by radioimmunoassay during the estrous cycle was found to be highest during estrus (68.5 ±7.4 ng/ml) and lowest in diestrus (27.6 ± 5.0 ng/ML), and there were no cyclic changes in serum prolACTin levels in mature male rats.
The Journal of Cell BiologyCELL PROLIFERATION AND SPECIALIZATION DURING ENDOCHONDRAL OSTEOGENESIS IN YOUNG RATS
309 Citations1962Richard W. Young
Endochondral osteogenesis was studied autoradiographically in ribs and tibiae of 32 Long-Evans rats injected with 1 µc/gm H3-thymidine at 6 days of age and sacrificed at intervals between 1 hour and 2 weeks later.
Proceedings of the National Academy of SciencesHormone-dependent differentiation of mammary gland in vitro.
222 Citations1965William G. Juergens, Frank E. Stockdale +2 more
Solubilization, by deoxycholate, of microsome- bound casein indicated that less than 10% of the biosynthetic material was bound to these par-ticles, and the results to be described were not altered when total rather than soluble casein was assayed.
The Journal of Cell BiologyDNA SYNTHESIS, MITOSIS, AND DIFFERENTIATION IN PANCREATIC ACINAR CELLS <i>IN VITRO </i>
176 Citations1964Norman K. Wessells
Observations of autoradiograms of H3-thymidine-labeled tissues indicate that the first cells which cease incorporating the DNA-precursor are in the central regions that differentiate first, whereas in older explants, thymidine incorporation is largely restricted to the periphery of the tissue as zymogen appears in the internal cells.
Proceedings of the National Academy of SciencesThe role of DNA synthesis and mitosis in hormone-dependent differentiation.
175 Citations1966Frank E. Stockdale, Yale J. Topper
It will be shown that DNA synthesis and/or cell division in mammary-gland epithelium is necessary for the initiation of differentiation (casein synthesis), and that daughter cells in this tissue have different functional properties when formed in different hormonal environments.
Proceedings of the National Academy of SciencesHeritability of cellular differentiation: clonal growth and expression of differentiation in retinal pigment cells in vitro.
167 Citations1966Robert D. Cahn, M B Cahn
Pitch discrimination in terms of place of action along the basilar membrane is largely lacking in this ear, and the recognition of sounds will have to be achieved by the use of frequency cues in the neural representation of pitch along with intensity and temporal patterns.
Elsevier eBooksMultiple Hormone Interactions in the Development of Mammary Gland in Vitro
160 Citations1970Yale J. Topper
Some of the hormone-mediated processes that occur during development of the mouse mammary gland in vitro are discussed, which provide opportunities for chemical dissection that facilitate analysis of sequential events occurring during development.
The Journal of Cell BiologySOME ULTRASTRUCTURAL EFFECTS OF INSULIN, HYDROCORTISONE, AND PROLACTIN ON MAMMARY GLAND EXPLANTS
138 Citations1970Elinor S. Mills, Yale J. Topper
The effects of insulin, hydrocortisone, and prolactin on the morphology of explants from midpregnant mouse mammary glands were studied and there is excellent correlation between the ultrastructural appearance of the alveoli and their capacity to synthesize casein.
Experimental Cell ResearchThe role of epithelial growth factor in mammary gland development in vitro
127 Citations1969Roger W. Turkington
It is demonstrated that EGF can act as a potent growth factor for the regulation of mammary epithelial cell proliferation, and it is suggested that it may function as a hormone.
EndocrinologySerum Levels of Prolactin, Luteinizing Hormone, and Follicle Stimulating Hormone During Pregnancy in the Rat1
112 Citations1972Daniel M. Linkie, G. D. Niswender
Serum levels of prolactin, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were determined in both groups by specific and sensitive radioimmunoassays, and Variation in the levels of FSH did not permit a meaningful conclusion regarding release of this hormone following mating.
Developmental BiologyA histological and biochemical study of hormone-dependent differentiation of mammary gland tissue in vitro
105 Citations1966Frank E. Stockdale, William G. Juergens +1 more
The combination of specific changes in cell and tissue structure and selective stimulation of one group of milk proteins constitutes an example of cellular differentiation under hormonal control.
Journal of Biological ChemistryHormone-dependent Accumulation of Rough Endoplasmic Reticulum in Mouse Mammary Epithelial Cells in Vitro
98 Citations1971Takami Oka, Yale J. Topper
EndocrinologyINFLUENCE OF INSULIN ON MAINTENANCE AND SECRETORY STIMULATION OF MOUSE MAMMARY TISSUES BY HORMONES IN ORGAN-CULTURE<sup>1</sup>
88 Citations1961E. M. Rivera, Howard A. Bern
The more differentiated the tissue in the direction of secretory activity, the greater was the need for cortisol in addition to insulin for maintenance in vitro, and the optimum concentrations of MH an...
Journal of Biological ChemistryAn Early Effect of Prolactin on the Formation of α-Lactalbumin by Mouse Mammary Epithelial Cells
68 Citations1973Barbara K. Vonderhaar, Ida S. Owens +1 more
Estradiol-17β, or prolactin, priming of mature virgin mice reduces the time required for the development of B- protein activity in the mammary explants, while the time course of casein synthesis and appearance of A-protein activity is not appreciably affected and the secretory proteins, casein and α-lactalbumin, develop synchronously.
EndocrinologyStimulation of Casein Synthesis and Histological Development of Mammary Gland by Human Placental Lactogen<i>in Vitro</i>
68 Citations1966Roger W. Turkington, Yale J. Topper
Experimental Biology and MedicineEffect of Insulin and Cortisol on Organ Cultures of Adult Mouse Mammary Gland.
65 Citations1959John J. Elias
Cortisol plus insulin, and to some extent insulin alone, maintained normal and hyperplastic mouse mammary lobules in organ culture in a defined medium.
The Journal of Cell BiologyPRIMITIVE ERYTHROPOIESIS IN EARLY CHICK EMBRYOGENESIS
65 Citations1971Graham Le M. Campbell, H Weintraub +2 more
The location of erythroblasts in the cell cycle was determined by combining Feulgen cytophotometry with thymidine radioautography and the distribution of Hb values for metaphase cells suggests that there are six Hb classes corresponding to the number of cell cycles in the proliferative phase.
EndocrinologyPlasma Luteinizing Hormone, Follicle-Stimulating Hormone and Prolactin During Pregnancy in the Mouse<sup>1</sup>
61 Citations1974SANDRA M. MURR, G. E. Bradford +1 more
Concentrations of LH, FSH and prolactin were measured by radioimmunoassay throughout pregnancy in mice exposed to light for 14 hr and assayed using the RIA for pituitary gonadotropins.
ScienceLobuloalveolar Differentiation in Mouse Mammary Tissues in vitro
58 Citations1964Ruby R. Ichinose, Satyabrata Nandi
Administration of lobuloalveolar mammogenic hormones to immature mice prior to cultivation of their mammary glands in chemically defined, hormone-supplemented media resulted in lobulo alveolar growth in vitro comparable to that of late pregnancy, but no such growth occurred in cultures of mammary tissues from mice not treated with hormones.
Proceedings of the National Academy of SciencesIs Prolactin Mitogenic for Mammary Epithelium?
46 Citations1972Takami Oka, Yale J. Topper
It appears that prolactin acts indirectly as a mitogen by rendering the cells susceptible to the aforementioned mitogens.
EndocrinologyStimulation of Mammary Epithelial Cell Proliferation<i>in Vitro</i>by Protein Factor (s) Present in Serum
30 Citations1971Gopal C. Majumder, Roger W. Turkington
Journal of EndocrinologyBIOCHEMICAL CHANGES DURING DEVELOPMENT OF MOUSE MAMMARY TISSUE IN ORGAN CULTURE
29 Citations1970Richard Mayne, J. M. Barry
Proceedings of the National Academy of SciencesA NOVEL ACTION OF INSULIN ON PHOSPHOPROTEIN FORMATION BY MAMMARY GLAND EXPLANTS
14 Citations1969Anthony E. Voytovich, Ida S. Owens +1 more
Studies on the induction of casein synthesis in competent daughter cells formed in mammary gland explants have revealed a new action of insulin.