The Direct and Enantioselective, One‐Pot, Three‐Component, Cross‐Mannich Reaction of Aldehydes
Angewandte ChemiePublished 7 August 2003
Yujiro Hayashi, Wataru Tsuboi, Itaru Ashimine, Tatsuya Urushima, Mitsuru Shoji, Ken Sakai
Citations270
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Abstract
Zweifach über Kreuz: Der Einsatz von Prolin als organischem Katalysator ermöglicht eine direkte gekreuzte Eintopf-Mannich-Reaktion zwischen zwei unterschiedlichen Aldehyden und 4-Methoxyanilin, die hochgradig syn-diastereo- und enantioselektiv abläuft.
Keywords
ChemistryBiochemistry, Genetics and Molecular Biology
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