Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene
NaturePublished 1 April 1984
Michael Karin, Alois Haslinger, Heidi Holtgreve, Robert I. Richards, P. Krauter, H.M. Westphal
Citations944
SJR quartileQ1
SJR score18.29
SNIP10.16
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TL;DR
Two stretches of DNA (genetic elements), lying close to the promoter for a human gene for metallothionein, that separately mediate the induction of the gene by heavy metal ions, particularly cadmium, and by glucocorticoid hormones are defined.
Abstract
Deletion experiments have defined two stretches of DNA (genetic elements), lying close to the promoter for a human gene for metallothionein, that separately mediate the induction of the gene by heavy metal ions, particularly cadmium, and by glucocorticoid hormones. The element responsible for induction by cadmium is duplicated, yet a single copy is fully functional; the element responsible for induction by glucocorticoid hormones is coincident with the DNA-binding site for the glucocorticoid hormone receptor.
Keywords
MedicineNursingEnvironmental Science
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