Trimethoprim-Sulfamethoxazole or Pentamidine for Pneumocystis Pneumonia in the Acquired Immunodeficiency Syndrome
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The use of trimethoprim-sulfomethoxazole or pentamidine for the treatment of Pneumocystis carinii pneumonia in p...
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Letters and Corrections1 October 1986Trimethoprim-Sulfamethoxazole or Pentamidine for Pneumocystis Pneumonia in the Acquired Immunodeficiency SyndromeTERRY DENNIS, M.D.TERRY DENNIS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-4-629_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The report by Wharton and colleagues (1) in the July issue on the use of trimethoprim-sulfomethoxazole or pentamidine for the treatment of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome (AIDS) was a valuable addition to the knowledge on treatment of this disorder. Although the trial appears to have been well designed, I believe the results (20% mortality in the trimethoprim-sulfamethoxazole group compared with 5% in the pentamidine group) are too easily discounted by the authors.The ñ value of 0.09 did not attain the alpha = 0.05 level; however, when the mortality rate is...References1. WHARTONCOLEMANWOFSY JDC. Trimethoprim-sulfamethoxazole or pentamidine for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome: a prospective randomized trial. Ann Intern Med. 1986;105:37-44. LinkGoogle Scholar2. LEOUNGMILLSHOPEWELLHUGHESWOFSY GJPWC. Dapronetrimethoprim for Pneumocystis carinii pneunonia in the acquired immunodeficiency syndrome. Ann Intern Med. 1986;105:45-8. LinkGoogle Scholar1. WHARTONCOLEMANWOFSY JDC. Trimethoprim-sulfamethoxazole or pentamidine for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome: a prospective randomized trial. Ann Intern Med. 1986;105:37-44. LinkGoogle Scholar2. SACKETTGENT DM. Controversy in counting and attributing events in clinical trials. N Engl J Med. 1979;301:1410-2. CrossrefMedlineGoogle Scholar3. REMINGTONSCHORK RM. Statistics, with Applications to the Biological and Health Sciences. 2nd ed. Englewood Cliffs, New Jersey: Prentice-Hall; 1985:192-4. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTreatment of Pneumocystis jirovecii pneumonia in HIV-infected patients: a reviewPneumocystis Jiroveci (Pneumocystis Carinii) InfectionsSilence, Death, and the Invisible Enemy: AIDS Activism and Social Movement "Newness"Management of Pneumocystis carinii Pneumonia in Patients with AIDS and Other Conditions: Experience in a Philadelphia University Teaching HospitalTrimethoprim-Sulfamethoxazole or Pentamidine for Pneumocystis carinii PneumoniaPAUL BÉGIN, M.D., JAMES HANLEY, Ph.D. 1 October 1986Volume 105, Issue 4Page: 629-630KeywordsAIDSDeath ratesMortalityPneumocystisPneumocystis carinii pneumoniaPneumonia Issue Published: 1 October 1986 PDF DownloadLoading ...