The influence of probenecid on the metabolism of serotonin, dopamine and their precursors in man
PsychopharmacologyPublished 1 June 1973
H. M. van Praag, F. Flentge, Jakob Korf, L. C. W. Dols, T Schut
Citations35
SJR quartileQ1
SJR score1.16
SNIP0.97
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TL;DR
It is suggested that in man, endogenously released and exogenous tryptophan enter different metabolic pools in the brain and this effect may well be of significance in the therapeutic application of 5-HT precursors.
Abstract
Probenecid inhibits the efflux of acid monoamine (MA) metabolites from the CNS. The probenecid-induced accumulation of these metabolites in the CSF in man supplies data on the central turnover of the corresponding amines. In this study an attempt was made to establish whether probenecid also exerts an influence on the metabolism of the MA precursors: tryptophan and tyrosine. The principal conclusions were the following.
Keywords
MedicineNeuroscienceBiochemistry, Genetics and Molecular Biology
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University of Groningen research database (University of Groningen / Centre for Information Technology)Amine metabolism in the human brain: evaluation of the probenecid test
6 Citations1971J. Korf
Indirect indications, that biogenic amines in the brain are concerned with pathological states such as depression and Parkonsonism are obtained from measurements of amines and their metabolites in pe - ripheral fluids and in postmortem specimens of brain tissue of patients.