Five-year outcomes of probable rheumatoid arthritis treated with methotrexate or placebo during the first year (the PROMPT study)
Annals of the Rheumatic DiseasesPublished 20 January 2013
Jill van Aken, L. Heimans, Henrike Gillet-van Dongen, Karen Visser, H. K. Ronday, I. Speyer
Citations53
SJR quartileQ1
SJR score5.73
SNIP4.44
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TL;DR
After 5 years there is no lasting benefit of a 1 year initial course of MTX for patients with undifferentiated arthritis, compared with initial placebo, and the progression of radiological damage was similar in both groups.
Abstract
After 5 years there is no lasting benefit of a 1 year initial course of MTX for patients with undifferentiated arthritis, compared with initial placebo. Progression to classifiable RA was not suppressed, drug-free remission not induced and the progression of radiological damage was similar in both groups. Reclassification at baseline with the 2010 criteria showed that 25% of patients with RA (2010) achieved spontaneous drug-free remission.
Keywords
Medicine
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