PUVA treatment of alopecia areata partialis, totalis and universalis: audit of 10 years' experience at St John's Institute of Dermatology
British Journal of DermatologyPublished 1 December 1995
Charles R. Taylor, J.L.M. HAWK
Citations116
SJR quartileQ1
SJR score2.46
SNIP2.35
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
It is affirm that PUVA is generally not an effective treatment for alopecia areata.
Abstract
Our 10-year experience with PUVA treatment for alopecia areata, partialis, totalis and universalis was retrospectively reviewed using charts and follow-up questionnaires for 70 patients at St John's Institute of Dermatology. In all cases, several previous therapies were judged to be unsatisfactory prior to starting PUVA, and many cases were already deemed clinically refractory prior to referral for PUVA. If cases of vellus hair growth are excluded, and those who lost their PUVA-induced regrowth rapidly on follow-up, the effective success rate was at best 6.3% for alopecia areata partialis, 12.5% for alopecia areata totalis and 13.3% for alopecia areata universalis. We affirm that PUVA is generally not an effective treatment for alopecia areata.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
Archives of DermatologyAlopecia Areata
410 Citations1963Sigfrid A. Muller
Alopecia areata has been described as associated with diseases of the endocrine glands, various tension states and emotional shock, errors of refraction, vitiligo, and neurodermatitis, and as a result of reflex irritations from focal lesions such as dental abscesses and from traumatic events.
Journal of the American Academy of DermatologyOral cyclosporine for the treatment of alopecia areata
183 Citations1990Aditya K. Gupta, Charles N. Ellis +8 more
A significant decrease in the CD4/CD8 ratio occurred early in the course of treatment and was maintained throughout the therapy, which suggests that cyclosporine not only cleared immune cells from the hair follicles but also altered the balance of regulatory lymphocytes.
Archives of DermatologySystemic Steroids With or Without 2% Topical Minoxidil in the Treatment of Alopecia Areata
140 Citations1992Elise A. Olsen
A 6-week taper of prednisone offers potential for more than 25% regrowth in 30% to 47% of patients with alopecia areata with predictable and transient side effects, and two percent topical minoxidil three times daily appears to help limit poststeroid hair loss.
Archives of DermatologyEvaluation of Anthralin in the Treatment of Alopecia Areata
131 Citations1987Virginia C. Fiedler‐Weiss
Therapy was relatively well tolerated, although all patients experienced pruritus and local erythema and scaling, and anthralin appears to be a reasonable therapeutic option for severe alopecia areata.
Journal of the American Academy of DermatologyTopical minoxidil solution (1% and 5%) in the treatment of alopecia areata
125 Citations1987Virginia C. Fiedler‐Weiss
The current 2% formulation is most likely to elicit cosmetically acceptable regrowth in those with patchy alopecia areata, and a finding of increased T cell blastogenesis before treatment may predict response.
Journal of the American Academy of DermatologyTreatment of alopecia areata with diphenylcyclopropenone
109 Citations1991P.H.M. van der Steen, H. M. J. van Baar +2 more
The most frequent side effects were eczematous reactions with blistering, spreading of the induced contact eczema, and sleep disturbances.
British Journal of DermatologyPUVA treatment for alopecia areata—does it work? A retrospective review of 102 cases
98 Citations1993Eugene Healy, S. Rogers
It is considered that PUVA is not an effective treatment for AA, and the use of PUVA in the treatment of severe alopecia areata is recommended.
Archives of DermatologyTreatment of Alopecia Areata by Anthralin-Induced Dermatitis
96 Citations1979Christian Schmoeckel
This report attempted to induce hair growth in patients with alopecia areata by producing an inflammatory nonallergic dermatitis by advising to apply anthralin as often as necessary in order to induce a visible but tolerable dermatitis.
Archives of DermatologyTreatment of Alopecia Areata With Dinitrochlorobenzene
92 Citations1978Lauren A. Daman
Augmentation of the T-lymphocyte pool via DNCB sensitization and challenge may become effective therapy for some patients with severe alopecia areata.
Archives of DermatologyPUVA Treatment of Alopecia Areata
79 Citations1983A Claudy
In the patients responding to treatment, the result did not seem to depend on the age of onset or the extent or duration of disease, however, patients with long-lasting alopecia had a higher risk of recurrence notwithstanding a good initial regrowth of hair.
Archives of DermatologyDinitrochlorobenzene Therapy for Alopecia Areata
73 Citations1978Rudolf Happle
Hair regrew either exclusively on the treated side, or considerably faster and denser on this side, suggesting that topically applied DNCB affects the peribulbar infiltrate present in alopecia areata.
Journal of the American Academy of DermatologyTopical photochemotherapy for alopecia areata
71 Citations1985Andrew J. Mitchell, Margaret Douglass
Despite the failure of topical PUVA to change the long-term course of alopecia, the combination of PUVA with other therapeutic modalities may result in the prolongation of the beneficial effect in selected patients.
DermatologicaPUVA Treatment for Alopecia areata
67 Citations2009A Lassus, Ursula Kianto +2 more
Patients over 20 years at the first attack of alopecia showed a better response than patients with an earlier onset of the disease and the number of irradiations required for regrowth varied but 20--40 treatments were sufficient in most cases with a positive response.
Archives of DermatologyEvaluation of Oral Minoxidil in the Treatment of Alopecia Areata
66 Citations1987Virginia C. Fiedler‐Weiss
It is suggested that improved preparations of topical minoxidil, when used as a single therapeutic agent, are unlikely to be cosmetically effective in the majority of patients with severe alopecia areata.
Archives of DermatologyTreatment-resistant alopecia areata. Response to combination therapy with minoxidil plus anthralin
64 Citations1990Virginia C. Fiedler
DermatologyPulse of Methylprednisolone in Alopecia areata
57 Citations2009J. Perriard-Wolfensberger, F. Pasche‐Koo +4 more
It is suggested that pulse corticotherapy can stop the course of severe AA in an active state, is well tolerated without major side effects and does not permit a stable control of AA of more than 1 year duration.
Dermatologic ClinicsAlopecia Areata
48 Citations1993Jerry Shapiro
The treatment of alopecia areata has changed markedly in the past decade and several options are now available to the patient, according to the dermatologist.
British Journal of DermatologySuccessful treatment of alopecia areata using the contact allergen diphencyprone
43 Citations1991S. MACDONALD HULL, W.J. Cunliffe
The risk of pregnancy attributable to the concomitant use of antibiotics appears to be very small, and it is suggested that these drugs can be safely prescribed.
PUVA-Therapy for Alopecia Areata
31 Citations1981Irving Weissmann, Cornelia Hofmann +1 more
Acta Dermato VenereologicaPUVA treatment of alopecia totalis
24 Citations1983O Larkö, G Swanbeck
40 patients with alopecia totalis treated with PUVA did not respond, 6 experienced a partial hair regrowth, while 8 got a complete regrowth; however, relapses were frequent, occurring at an early stage.
Acta Dermato VenereologicaTreatment of alopecia areata with DNCB--an immunostimulation?
24 Citations1977G Frentz, K. Eriksen
Ten patients with long-standing areate type alopecia totalis were sensitized with 1-chloro, 2, 4-dinitrobenzene (DNCB) and painted once weekly on a 40 X 20 mm area of the vertex with DNCB in acetone, in concentrations adjusted to the allergic response.
Archives of DermatologySystemic steroids with or without 2% topical minoxidil in the treatment of alopecia areata
24 Citations1992Elise A. Olsen
Archives of DermatologyTreatment of alopecia areata with dinitrochlorobenzene
22 Citations1978L. A. Daman
DermatologicaTopical Treatment of Extended Alopecia
16 Citations2009G Frentz
Two groups of patients with subtotal to universal areate type alopecia were serially treated with intralesional triamcinolone acetonide suspension and contact irradiation by ultraviolet light from a high-pressure mercury-arc source with a quartz envelope (Kromayer lamp).
Archives of DermatologyTreatment of alopecia areata by anthralin-induced dermatitis
15 Citations1979C. Schmoeckel
Archives of DermatologyTrial of Intralesional Interferon Alfa in the Treatment of Alopecia Areata
13 Citations1990Karen L. Magee
Immunohistochemical studies showed some changes in the inflammatory infiltrates and in HLA-DR expression that may be related to the interferon or to the dynamics of the inflammatory infiltrate in alopecia areata.
Archives of DermatologyEvaluation of anthralin in the treatment of alopecia areata
11 Citations1987Virginia C. Fiedler‐Weiss