P-glycoprotein expression of the human placenta during pregnancy
PlacentaPublished 24 August 2004
Sophie Gil, Robert Saura, F Forestier, Robert Farinotti
Citations141
SJR quartileQ1
SJR score0.94
SNIP0.89
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
As P-glycoprotein appears to be involved in drug extrusion, these data suggest that the placenta's ability to protect the fetus from xenobiotics is greater in early pregnancy than at term.
Abstract
As P-glycoprotein appears to be involved in drug extrusion, these data suggest that the placenta's ability to protect the fetus from xenobiotics is greater in early pregnancy than at term.
Keywords
Medicine
Proceedings of the National Academy of SciencesFunctional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity <i>in</i> <i>vivo</i>
2,363 Citations2000Sven Hoffmeyer, Oliver Burk +9 more
A significant correlation of a polymorphism in exon 26 (C3435T) of MDR-1 with expression levels and function is observed and this polymorphism is expected to affect the absorption and tissue concentrations of numerous other substrates of M DR-1.
Journal of Histochemistry & CytochemistryExpression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.
1,071 Citations1990Carlos Cordon‐Cardo, James P. O’Brien +4 more
Pgp expression in capillaries of the brain and testis may explain the failure of drugs such as vincristine and actinomycin-D to penetrate into tissues, allowing them to remain as pharmacological sanctuaries for malignant cells.
Journal of Pharmacology and Experimental TherapeuticsExpression of P-glycoprotein in Human Placenta: Relation to Genetic Polymorphism of the Multidrug Resistance (MDR)-1 Gene
535 Citations2001Mizuho Tanabe, Ichiro Ieiri +10 more
Although it remains to be determined whether these SNPs influence the pharmacokinetic and dynamic properties of clinically useful drugs that are substrates of PGP, the polymorphism of the MDR-1 gene presented here may provide useful information in in vivo study of these issues.
BiochemistryHIV-1 Protease Inhibitors Are Substrates for the<i>MDR</i>1 Multidrug Transporter
482 Citations1998Caroline Lee, Michael M. Gottesman +6 more
It is indicated that cells in patients that express the MDR1 transporter will be relatively resistant to the anti-viral effects of the HIV-1 protease inhibitors, and that absorption, excretion, and distribution of these inhibitors in the body may be affected by the multidrug transporter.
Journal of Clinical InvestigationAbsence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure
355 Citations1999Johan W. Smit, Maarten T. Huisman +3 more
The findings imply that the placental drug-transporting P-gp is of great importance in limiting the fetal penetration of various potentially harmful or therapeutic compounds and demonstrate that this P- gp function can be abolished by pharmacological means.
American Journal of Physiology-Regulatory, Integrative and Comparative PhysiologyExpression of members of the multidrug resistance protein family in human term placenta
327 Citations2000Marie V. St–Pierre, María A. Serrano +6 more
It is hypothesize that MRP isoforms serve to protect fetal blood from entry of organic anions and to promote the excretion of glutathione/glucuronide metabolites in the maternal circulation.
Clinical PharmacokineticsPlacental Transfer of Drugs Administered to the Mother
317 Citations1995Gian Maria Pacifici, Rita Nottoli
A careful analysis of the literature suggests that all drugs cross the placenta, although the extent transfer varies considerably, and that the impression prevails that suxamethonium chloride (succinylcholine chloride) and doxorubicin do not cross the Placenta is wrong.
Reproductive ToxicologyPlacental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice
310 Citations1998George R. Lankas, L. David Wise +3 more
The results demonstrate the importance of placental Pgp in protecting the fetus from potential teratogens and suggest that Pgp inhibitors should be carefully evaluated for their potential to increase susceptibility to chemical-induced teratogenesis.
The LancetFrequency of C3435T polymorphism of MDR1 gene in African people
283 Citations2001Elke Schaeffeler, Michel Eichelbaum +5 more
Concentration of P-glycoprotein in intestinal epithelial cells and in a subset of lymphoid cells is substantially lower in people with the T/T genotype than those with the C/C genotype.
American Journal of Physiology-Cell PhysiologyPermeability properties of monolayers of the human trophoblast cell line BeWo
200 Citations1997Fei Liu, Michael J. Soares +1 more
F Forskolin and 8-bromoadenosine 3',5'-cyclic monophosphate treatments stimulated morphological changes in BeWo cultures and enhanced the asymmetric passage of linoleic acid across the BeWo monolayers while having minimal effects on passive permeability, affirming that the differentiation state of the cells can influence membrane transporters and transmonolayer permeability.
Advanced Drug Delivery ReviewsEfflux transporters of the human placenta
175 Citations2003Amber Young, Courtni E. Allen +1 more
Investigating the link between the hormones of pregnancy and these drug efflux transporters is one possible key in developing strategies to deliver drugs to the mother with minimal fetal risk.
European Journal of PharmacologyHuman placental transport of vinblastine, vincristine, digoxin and progesterone: contribution of P-glycoprotein
143 Citations2000Fumihiko Ushigome, Hitomi Takanaga +9 more
Data suggest that P-glycoprotein is expressed on the brush-border membrane (maternal side) of human placental trophoblast cells, and is considered to regulate the transfer of several substances including vinblastine, vincristine and digoxin from mother to fetus, and to protect the fetus from toxic substances.
Biochemical and Biophysical Research CommunicationsFunction of P-Glycoprotein Expressed in Placenta and Mole
116 Citations1997Yukihiko Nakamura, Shun‐ichi Ikeda +5 more
Findings indicate that P-glycoprotein expressed in trophoblasts has a drug binding site(s) and the ability to transport vincristine, suggesting that P -glycop protein in the placenta protects the fetus from xenobiotics and confers drug resistance on moles.
The Histochemical JournalStage-specific distribution of P-glycoprotein in first-trimester and full-term human placenta
94 Citations1994Amrit K. MacFarland, D. R. Abramovich +2 more
Results point to distinct functions for P-glycoprotein during the different stages of placental development and indicate that its expression may be under developmental control.
Reproductive ToxicologyFunctional expression of P-glycoprotein in primary cultures of human cytotrophoblasts and BeWo cells☆
75 Citations2000Naoki Utoguchi, Gurudatt Chandorkar +2 more
Functional P-gp in term human trophoblasts is demonstrated and the use of primary cultures of human cytotrophoblasts and BeWo cells as in vitro models of the trophoblast to investigate mechanisms regulating drug distribution across the placenta is supported.
Journal of Pharmaceutical SciencesInfluence of P‐Glycoprotein on the Transplacental Passage of Cyclosporine
65 Citations2001Petr Pávek, Z. Fendrich +7 more
Findings indicate that P-glycoprotein pumps cyclosporine out of the trophoblast cells of the rat placenta in the ATP-dependent manner and restricts the passage of cyclospora across the placental barrier.
American Journal of Obstetrics and GynecologyMaternal-fetal transfer of saquinavir studied in the ex vivo placental perfusion model
60 Citations2001François Forestier, Patrick de Renty +4 more
The low rate of placental transfer of saquinavir suggests that use of this antiretroviral drug by pregnant women may not lead to significant exposure of the fetus.
Molecular Human ReproductionExpression of the cystic fibrosis (CF) and multidrug resistance (MDR1) genes during development and differentiation in the human placenta
47 Citations1996Photini V. Mylona, Jocelyn D. Glazier +3 more
It is demonstrated that both the CF and MDR1 genes are expressed in the human placenta at all stages of development and differentiation, although the expression of the CF, but not the MDR 1, gene appears to be much weaker in the undifferentiated JAr cells in comparison with cytotrophoblast cells.
