Does Acute Normovolemic Hemodilution Reduce Perioperative Allogeneic Transfusion? A Meta-Analysis
Anesthesia & AnalgesiaPublished 1 January 1998
Gregory L. Bryson, Katharine Ker, George A. Wells
Citations215
SJR quartileQ1
SJR score1.16
SNIP1.63
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
Abstract
after a systematic literature review, 24 randomized trials examining the role of acute normovolemic hemodilution were identified, pooled, and summarized using statistical techniques. Many studies reported an impressive reduction in blood transfused. Closer examination suggests that these reductions in blood exposure may be due to flawed study design.
Keywords
Medicine
Controlled Clinical TrialsAssessing the quality of reports of randomized clinical trials: Is blinding necessary?
17,565 Citations1996Alejandro R. Jadad, R Andrew Moore +5 more
An instrument to assess the quality of reports of randomized clinical trials (RCTs) in pain research is described and its use to determine the effect of rater blinding on the assessments of quality is described.
New England Journal of MedicineThe Risk of Transfusion-Transmitted Viral Infections
1,894 Citations1996George B. Schreiber, Michael P. Busch +2 more
The risk of transmitting HIV, HTLV, HCV, or HBV infection by the transfusion of screened blood is very small, and new screening tests will reduce the risk even further.
The LancetEffect of anaemia and cardiovascular disease on surgical mortality and morbidity
1,004 Citations1996Jeffrey L. Carson, Amy Duff +6 more
A low preoperative haemoglobin or a substantial operative blood loss increases the risk of death or serious morbidity more in patients with cardiovascular disease than in those without.
Statistics in MedicineA comparison of statistical methods for combining event rates from clinical trials
427 Citations1989Jesse A. Berlin, Nan M. Laird +2 more
Two statistical methods for combining event rates from several studies are compared and the presence of heterogeneity influences the conclusion that the DerSimonian and Laird modified Cochran method tends to be more conservative.
Journal of Thoracic and Cardiovascular SurgeryAutologous blood transfusion during cardiac surgery
94 Citations1977Joel A. Kaplan, Charles F. Cannarella +4 more
Heparinized autologous blood removed from the vena cava cannula was the only technique which significantly improved the PTT and platelet count and there was a saving of 18 percent in banked blood requirements.
Journal of Thoracic and Cardiovascular SurgeryReduction of blood utilization during myocardial revascularization
80 Citations1989Wulf Dietrich, A Barankay +3 more
It is concluded that the use of blood conservation techniques can considerably reduce the homologous blood requirement in cardiac operations and therefore decrease transfusion-related risks.
The Annals of Thoracic SurgeryIntraoperative autotransfusion reduces blood loss after cardiopulmonary bypass
75 Citations1996Gary S. Kochamba, Thomas Pfeffer +2 more
Autotransfusion during cardiopulmonary bypass provides benefit in addition to other techniques in reducing blood loss and the need for blood products in the postoperative period.
TransfusionEfficacy of autologous fresh whole blood or platelet‐rich plasma in adult cardiac surgery
58 Citations1995Darrell J. Triulzi, G.D. Gilmor +3 more
Transfusing fresh autologous blood during cardiac surgery may improve hemostasis and decrease the need for transfusion.
Annals of SurgeryFresh Autologous Blood Transfusions with Extracorporeal Circulation
57 Citations1973John L. Ochsner, Noel L. Mills +2 more
Journal of Surgical ResearchIntraoperative normovolemic hemodilution
56 Citations1981David D. Rose, Theodore Coutsoftides
Acute normovolemic hemodilution is an effective clinical means of reducing the use of bank blood and avoiding the risks of blood transfusion in patients undergoing major surgery.
Statistics in MedicineA meta‐analysis of clinical trials involving different classifications of response into ordered categories
52 Citations1994Anne Whitehead, Nicola Jones
This article presents statistical methods for combining studies which involve different classifications of response into ordered categories, and the assumptions required for the stratified proportional odds model, on which the analysis is based.
Journal of Thoracic and Cardiovascular SurgeryFailure of transfusion of autologous whole blood to reduce banked-blood requirements in open-heart surgical patients
50 Citations1975Michael B. Pliam, Dwight C. McGoon +1 more
Although transfusion of autologous blood by the method described would seem to be a safe and proctical means of reducing banked-blood requirements for open-heart operations, experience indicates that the amount of blood needed to be added to the pump oxygenator more than negates the value in reducing intraoperative blood requirements.
The Annals of Thoracic SurgeryComparison of blood reinfusion techniques used during coronary artery bypass grafting
48 Citations1993Victor A. Ferraris, William R. Berry +1 more
A comparison of intraoperative autologous blood conservation techniques was carried out in 100 patients undergoing coronary artery bypass grafting, and no intraoperative blood infusion method resulted in significant improvement in postoperative blood use.
Anesthesia & AnalgesiaThe Use of Hemodilution and Fresh Autologous Blood in Open-Heart Surgery
48 Citations1974Noel W. Lawson, John L. Ochsner +2 more
An improved technic of hemospasia is described which reduces the demand for bank blood by roughly 50 percent, attesting to the efficacy of a relatively brief period of extracorporeal circulation.
Journal of Cardiothoracic and Vascular AnesthesiaRETRACTED: Acute preoperative hemodilution in cardiac surgery: Volume replacement with a hypertonic saline-hydroxyethyl starch solution
46 Citations1991Joachim Boldt, Dieter Kling +5 more
HS solution prepared in HES is an attractive alternative for blood substitution in cardiac patients undergoing acute hemodilution for blood conservation and CI increased most in the HS-HES group, whereas systemic vascular resistance was lower in these patients.
Acta Anaesthesiologica ScandinavicaCardiovascular effects of moderate normovolaemic haemodilution during enflurane–nitrous oxide anaesthesia in man
43 Citations1994Philippe Van der Linden, M. WATHIEU +5 more
The cardiovascular effects of mild normovolaemic haemodilution during enflurane–nitrous oxide anaesthesia were studied in 20 patients with normal cardiac function before, during and after total hip replacement, finding that cardiac index was higher in the haemmodiluted group than in the control group, so that O2 delivery was similar in the two groups.
Journal of Cardiothoracic and Vascular AnesthesiaReduction in blood loss and blood use after cardiopulmonary bypass with high-dose aprotinin versus autologous fresh whole blood transfusion
42 Citations1992C. Védrinne, Claude Girard +6 more
High-dose aprotinin reduced blood loss and transfusion requirements in patients undergoing cardiac surgery and had no significant hemostatic effect and failed to reduce the homologous blood requirement.
Anesthesia & AnalgesiaEffect of Preoperative Normovolemic Hemodilution on Left Ventricular Segmental Wall Motion During Abdominal Aortic Surgery
42 Citations1992Patrick Catoire, M. Saada +4 more
The observed changes in SWM indicate that PNH may not worsen myocardial ischemia in patients scheduled to undergo aortic surgery and may improve hemodynamic tolerance to aorti clamping in patients with coronary artery disease.
AnaesthesiaComparative study of limited intentional normovolaemic haemodilution in patients with left main coronary artery stenosis
41 Citations1995Luc Herregods, L. Foubert +3 more
Limited intentional normovolaemic haemodilution can be performed safely in patients with left main coronary artery stenosis and was not associated with increased frequency, severity or duration of ST‐segment changes, or with arrhythmias or haemodynamic instability.
Journal of Vascular SurgeryThe preservation of renal function by isovolemic hemodilution during aortic operations
34 Citations1993Mark Welch, David G. Knight +3 more
Hemodilution prevented the fall in cardiac output induced by cross-clamping and significantly reduced the need for transfusion of donor blood in patients undergoing elective aortic operation.
PubMedBlood coagulation during and after normovolemic hemodilution in elective surgery.
25 Citations1981B. Rosberg
In two randomized groups of patients undergoing hip arthroplasty preoperative normovolemic hemodilution with dextran 70 was compared to conventional bank blood transfusion, there was a significant reduction in the number of silent pulmonary emboli in the he modilution group.
Anesthesia & AnalgesiaDoes Timing of Hemodilution Influence the Stress Response and Overall Outcome?
21 Citations1993Mohamed M. Atallah, Sameh M. Abdelbaky +1 more
Hemodilution performed in awake or in anesthetized patients did not result in significant hemodynamic disruption, or result in detectable end-organ or stress-hormone changes when compared to control patient outcomes after radical cystectomy.
European Surgical ResearchHemostasis after Open-Heart Surgery with Extreme or Moderate Hemodilution
18 Citations2008Jeremy Dale, Per Lilleaasen +1 more
Patients who received aortic disc valves during cardiopulmonary bypass with extreme hemodilution, obtained with preoperative blood withdrawal, infusion of acetate solution and use of blood-free priming fluid, bled less than patients operated with moderate dilution.
Annales Françaises d Anesthésie et de RéanimationIntérêt de l'hémodilution en chirurgie maxillo-faciale sur l'œdème traumatique postopératoire et sur la vitalité des lambeaux
17 Citations1986M.C. Bonnet, J.M. Julia +2 more
PubMed[Prevention of thromboembolic disease and post-transfusional complications using normovolemic hemodilution in arthroplasty surgery of the hip].
13 Citations1990Vara Thorbeck R, Rosell Pradas J +3 more
It is shown that haemodilution is the best way to prevent postoperative thrombo-embolism, significantly more effective than Heparin and Dextran, in arthroplastic hip surgery.
PubMed[Acute normovolemic hemodilution in extensive surgical interventions].
10 Citations1986von Bormann B, B. Weidler +5 more
Haemodilution led to typical haemodynamic effects such as increase in cardiac index and decrease in systemic as well as pulmonary vascular resistance; no detrimental effect of the procedure could be observed.
PubMedPreoperative normovolemic hemodilution in total hip arthroplasty. A clinical study.
8 Citations1977A Ahlberg, A Nillius +2 more
Pre-operative normovolemic hemodilution was used in 20 patients undergoing total hip replacement and there was no significant difference in clinical complications between the two groups.
