Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice
PsychopharmacologyPublished 25 May 2001
Irwin Lucki, Ashutosh Dalvi, Arthur J. Mayorga
Citations508
SJR quartileQ1
SJR score1.16
SNIP0.97
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
Abstract
Background strain is a critical variable in determining baseline performance and the sensitivity to different types of antidepressant drugs in the mouse FST. The use of such mouse strains may provide information on the genetic basis for strain differences in depressive behavior and differential sensitivity to diverse classes of antidepressants.
Keywords
NeuroscienceBiochemistry, Genetics and Molecular Biology
NatureDepression: a new animal model sensitive to antidepressant treatments
4,421 Citations1977Roger D. Porsolt, Manuel Pichon +1 more
Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
PubMedBehavioral despair in mice: a primary screening test for antidepressants.
3,284 Citations1977Porsolt Rd, Aurélie Bertin +1 more
The mouse procedure is more rapid and less costly than that with rats and is thus more suitable for the primary screening of antidepressant drugs, suggesting that the procedure is selectively sensitive to antidepressant treatments.
PsychopharmacologyBehavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies
1,368 Citations1997Jacqueline N. Crawley, John K. Belknap +11 more
Strain distributions are described for open field activity, learning and memory tasks, aggression, sexual and parental behaviors, acoustic startle and prepulse inhibition, and the behavioral actions of ethanol, nicotine, cocaine, opiates, antipsychotics, and anxiolytics.
PsychopharmacologyIs the forced swimming test a suitable model for revealing antidepressant activity?
1,047 Citations1988Franco Borsini, Alberto Meli
This test appears to be suitable for detecting antidepressant activity in rats but not in mice, and difference in experimental procedure may account for the different sensitivity to drugs of the two animal species.
Psychological MedicineThe role of defeat and entrapment (arrested flight) in depression: an exploration of an evolutionary view
967 Citations1998Paul Gilbert, Steven Allan
Trends in NeurosciencesGene-targeting studies of mammalian behavior: is it the mutation or the background genotype?
885 Citations1996Robert Gerlai
The present article will demonstrate that the phenotypical abnormalities attributed to the null mutation in several molecular neurobiological studies could simply result from the effects of background genes.
Behavioural PharmacologyThe forced swimming test as a model for core and component behavioral effects of antidepressant drugs
795 Citations1997Irwin Lucki
The revised scoring of the forced swimming test corresponds to a behavioral test for antidepressant drugs that meet these criteria and should be sensitive to all antidepressant drugs and should also display multiple components that are sensitive to specific drug classes.
PsychopharmacologyDifferences in fear motivated behaviors among inbred mouse strains
450 Citations1993Ramón Trullás, Phil Skolnick
Results indicate that genetic factors substantially contribute to fear motivated behaviors in these animal models of anxiety and the use of such inbred mouse strains may provide a novel approach to investigate the biochemical and genetic bases of fear.
PsychopharmacologyDifferences in anxiety-related behaviours and in sensitivity to diazepam in inbred and outbred strains of mice
419 Citations2000Guy Griebel, Catherine Belzung +2 more
The finding of differential strain distributions both with and without diazepam treatment in the light/dark and the elevated plus-maze tests, indicates that not all strains of mice are suitable for investigating the effects of GABA/BZ receptor ligands.
PsychopharmacologySerotonergic mediation of the effects of fluoxetine, but not desipramine, in the rat forced swimming test
383 Citations1999M.E. Page, Michael J. Detke +3 more
Depletion of serotonin prevented the behavioral effects of the selective serotonin reuptake inhibitor fluoxetine in the rat FST, and depletion of serotonin had no impact on the behavior effects induced by the selective norepinephrine reptake inhibitor, desipramine.
PharmacopsychiatryThe Revised Monoamine Theory of Depression: A Modulatory Role for Monoamines, Based on New Findings From Monoamine Depletion Experiments in Humans
381 Citations1996George R. Heninger, Pedro L. Delgado +1 more
The findings that relapse to serotonin depletion or to catecholamine depletion was found to bespecifictothetype of antidepressant treatment, i.e. patients responding to selective serotonin reuptake inhlbilltors relapsed more frequently following SD than CD and patientsresponding to selective cate-cholamines reptake inhibitors relapsedMore frequently following CD than SD.
ScienceGenetic Aspects of Learning and Memory in Mice
375 Citations1969D Bovet, F. Bovet‐Nitti +1 more
NeuroscienceAssessment of learning by the Morris water task and fear conditioning in inbred mouse strains and F1 hybrids: implications of genetic background for single gene mutations and quantitative trait loci analyses
353 Citations1997Elizabeth H. Owen, Sheree F. Logue +2 more
Significant genetic correlations were obtained for behavioural measures suggesting that the same genes regulate various aspects of performance on behavioural tasks, confirming the importance of genetic background in the performance of various learning tasks.
Behavioural Brain ResearchDetection of serotonergic and noradrenergic antidepressants in the rat forced swimming test: the effects of water depth
346 Citations1995Michael J. Detke, Irwin Lucki
Results obtained with the technique demonstrate that selective serotonin reuptake inhibitors are not false negatives in the rat forced swimming test, as previously thought.
Physiology & BehaviorOpen field, learned helplessness, conditioned defensive burying, and forced-swim tests in WKY rats
262 Citations1994William P. Paré
The data suggested that the use of WKY rats represented a more sensitive procedure for detecting possible relationships between putative animal models of depressive behavior.
Journal of Pharmacology and Experimental TherapeuticsSertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin.
258 Citations1983B. Kenneth Koe, Arthur D. Weissman +2 more
It is proposed that selective blockade of serotonin reuptake can induce activation of norepinephrine neurons and subsequent down-regulation of norpinephrine receptors and that sertraline, a highly selective inhibitor of serotonin uptake, may be an efficacious antidepressant without anticholinergic or cardiovascular side-effects.
PsychopharmacologyBehavioral profiles of SSRIs in animal models of depression, anxiety and aggression
255 Citations1997Connie Sánchez, Eddi Meier
Citalopram produced a mixed anxiogenic-/anxiolyticlike response in rats tested in the two-compartment black and white box and ritanserin potentiated the antiaggressive effect of 1,5-HTP as well as that of 8-OH-DPAT.
Neuroscience & Biobehavioral ReviewsRole of the serotonergic system in the forced swimming test
241 Citations1995Franco Borsini
The 5-HT system does not play a tonic role in animals performing the forced swimming test and the involvement of possible brain regions mediating the anti-immobility effects of 5- HT mimetic drugs has been discussed.
NeuroscienceAssessment of locomotor activity, acoustic and tactile startle, and prepulse inhibition of startle in inbred mouse strains and F1 hybrids: Implications of genetic background for single gene and quantitative trait loci analyses
215 Citations1997Sheree F. Logue, Elizabeth H. Owen +2 more
The range of variability among genotypes was dependent on the specific measure so careful consideration must be made in selecting a strain for testing a particular behaviour, and quantitative trait loci methods could be applied to these behaviours.
British Journal of Medical PsychologyEthological strategies for defence in animals and humans: Their role in some psychiatric disorders
199 Citations1998A. K. Dixon
It is proposed that cut-offs always denote the presence of incipient flight and that arrested flight is a 'last measure' defensive strategy in response to inescapable proximal threat in humans.
Brain Research BulletinBaseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains
181 Citations1982Jacqueline N. Crawley, L. G. Davis
Inbred mouse strains showing variability in spontaneous exploratory behaviors displayed differential responsiveness to diazepam in an anxiety-related exploration model, and no correlation was seen between those behavioral responses and the characteristics of brain benzodiazepine binding sites in the different strains.
Pharmacology Biochemistry and BehaviorGenetic influences on nicotine responses
167 Citations1989Michael J. Marks, Jerry A. Stitzel +1 more
Comparison of the results from the six tests measured in this study and the results previously reported for nicotine-induced seizures in these same strains indicated that the responses could be grouped into two major classes: a set characterized by Y-maze crosses, Y- maze rears and body temperature and a set characterize by seizure sensitivity and seizure latency.
European Journal of PharmacologyForced swimming test in rats: effect of desipramine administration and the period of exposure to the test on struggling behavior, swimming, immobility and defecation rate
154 Citations1988Antonio Armario, Amadeu Gavaldà +1 more
The present results indicate that a one-day test can be used to discriminate between saline- and desipramine-treated rats, and that struggling behavior could be a reliable measure of the positive action of antidepressants.
Physiology & BehaviorOpioid and Nonopioid Swim Stress-Induced Analgesia: A Parametric Analysis in Mice
151 Citations1996Jeffrey S. Mogil, Wendy F. Sternberg +3 more
In selectively bred mice, analgesia and hypothermia from forced swimming are positively correlated, but can be dissociated both genetically and neurochemically, and swimming in body temperature water produces analgesia without concommitant Hypothermia.
Cellular and Molecular Life SciencesUsing genetically-defined rodent strains for the identification of hippocampal traits relevant for two-way avoidance behavior: a non-invasive approach
126 Citations1989Hans‐Peter Lipp, Herbert Schwegler +5 more
Biological PsychiatryA review of the efficacy of serotonergic and noradrenergic reuptake inhibitors for treatment of major depression
125 Citations1999J. Craig Nelson
The literature was reviewed to identify double-blind, random assignment studies comparing SSRIs and NRIs, with adequate description of methods and outcome, which appeared to be equally effective.
Pharmacology Biochemistry and BehaviorStrain comparison of nicotine-induced seizure sensitivity and nicotinic receptors
124 Citations1989Lucinda L. Miner, Allan C. Collins
A significant relationship was observed between BTX binding in the three brain regions and sensitivity to IV nicotine-induced seizures such that strains with greater concentrations of BTXbinding sites were more sensitive to nicotine- induced seizures than were strains with lower concentrations ofBTX binding sites.
Behavioral NeuroscienceInheritance of spatial learning ability in inbred mice: A classical genetic analysis.
122 Citations1989Margaret Upchurch, Jeanne M. Wehner
The inheritance of spatial learning ability in inbred mice was examined by performance of a classical genetic cross between the 2 inbred strains C57BL/6Ibg and DBA/2Ibg, with males showing a type of inheritance in which dominant genes made the major contribution to the expression of the behavior.
European Journal of PharmacologyThe role of 5-HT1A and 5-HT1B receptors in antidepressant drug actions in the mouse forced swimming test
119 Citations1996John P. Redrobe, Cliona MacSweeney +1 more
The anti-immobility effects of the selective serotonin reuptake inhibitors in the forced swimming test seem to be mediated by presynaptic 5-HT1A receptors as well as postsynaptic 5 -HT1B receptors.
PsychobiologyBehavioral dissociations between C57BL/6 and DBA/2 mice on learning and memory tasks: A hippocampal-dysfunction hypothesis
118 Citations1993Richard Paylor, Linda Baskall +1 more
It is shown that DBA mice do not have a general learning impairment, since they can solve two different discrimination problems and perform as well as C57 mice on a response-tendency task and a nonconditional learning task.
Behavior GeneticsCharacterization of benzodiazepine-sensitive behaviors in the A/J and C57BL/6J inbred strains of mice
112 Citations1994Chantal Mathis, Steven M. Paul +1 more
C57BL/6J and A/J mice should be useful parental strains in recombinant inbred lines for investigating the genetic determinants of benzodiazepine-sensitive behaviors and sensitivity to drugs acting on the GABAA/benzodiazepines receptor complex.
Behavioral and Neural BiologySearching—waiting strategy: A candidate for an evolutionary model of depression?
107 Citations1984Bernard Thierry, Lucien Stéru +2 more
The model proposed here assumes that depressive disorders could reflect an extreme state of a current behavioral strategy, namely, infant response to maternal separation in monkeys and "behavioral despair" in rodents.
PsychopharmacologyPurine nucleoside ? mediated immobility in mice: Reversal by antidepressants
103 Citations1985S. K. Kulkarni, Ashok K. Mehta
Results indicate that adenosine and 2-chloroadenosine probably reduce norepinephrine outflow through their action on presynaptic purinoceptors on noradrenergic neurons and thereby cause prolongation of immobility in animals.
Journal of Pharmacology and Experimental TherapeuticsRegulation of Extracellular Concentrations of 5-Hydroxytryptamine (5-HT) in Mouse Striatum by 5-HT1A and 5-HT1B Receptors
98 Citations2000D A Knobelman, Hank F. Kung +1 more
The present findings suggest that, on systemic administration, both 8-OH-PIPAT and CP 94,253 are potent and selective agonists at the somatodendritic 5-HT(1A) autoreceptor and terminal 5- HT(1B/1D) Autoreceptor, respectively, and are each able to cause decreases in extracellular levels in the mouse striatum by activating a distinct set of receptors.
PsychopharmacologyDiscrimination and self-administration of nicotine by inbred strains of mice
97 Citations1999Ian P. Stolerman, Christopher G. Naylor +2 more
The results of the IV self-administration study suggest that nicotine can serve as a positive reinforcer in drug–naive C57BL/6J mice, and possible approaches for genetic analyses of strain differences in sensitivity to the discriminative and reinforcing stimulus properties of nicotine are provided.
Pharmacology Biochemistry and BehaviorAlterations of central norepinephrine, dopamine and serotonin in several strains of mice following acute stressor exposure
97 Citations1991Nola Shanks, Steve Zalcman +2 more
Strain-specific neurochemical alterations following footshock are discussed relative to stressor-induced behavioral disturbances and animal models of depression.
Alcoholism Clinical and Experimental ResearchTolerance to Ethanol Hypothermia in Inbred Mice: Genotypic Correlations with Behavioral Responses
97 Citations1982John C. Crabbe, Jeri S. Janowsky +4 more
Although there were significant strain differences in activity reduction, ataxia, blood-ethanol concentrations, and changes in these parameters during the course of chronic treatment, none of these variables could explain the genetic differences in hypothermic sensitivity and tolerance.
Pharmacology Biochemistry and BehaviorSex and Genotype Determine the Selective Activation of Neurochemically-Distinct Mechanisms of Swim Stress-Induced Analgesia
90 Citations1997Jeffrey S. Mogil, John K. Belknap
The hypothesis that genetic factors and sex, in addition to stressor parameters, can determine the selective recruitment of alternative central mechanisms of pain inhibition is supported.
PsychopharmacologyGenetic differences in a tail suspension test for evaluating antidepressant activity
83 Citations1989Ramón Trullás, Barrington Jackson +1 more
Findings strongly suggest that performance in this proposed animal model of depression is under specific genetic control, and may provide a useful tool to study neurochemical and neuroendocrine correlates of depression and antidepressant action.
Pharmacology Biochemistry and BehaviorAn analysis of cocaine effects on locomotor activities and heart rate in four inbred mouse strains
82 Citations1988James A. Ruth, Elizabeth A. Ullman +1 more
The results suggest a genetically-determined difference in CNS sensitivity to cocaine in inbred strains of mouse, with C3H mice being considerably more sensitive than DBA or C57BL.
Behavior GeneticsLearning in inbred mice: Strain-specific abilities across three radial maze problems
78 Citations1993Martine Ammassari‐Teule, H Hoffmann +1 more
The high performance shown by C57 mice in all problems seems to be related to their ability to build up maze-running patterns based upon an optimal proportion of 45° angle turns, according to the demand of the situation.
Pharmacology Biochemistry and BehaviorEffect of changes in swimming area on results of “behavioral despair test”
77 Citations1994R. SUNAL, Bülent Gümüşel +1 more
The extension of the test period to 15 min increased the reliability of the measurement of the time to reach complete immobility and allowed to study the selective effect of the antidepressants, namely, the rotatory locomotor activity during swimming.
European Journal of PharmacologyAntidepressant-like activity of the melatonin receptor antagonist, luzindole (N-0774), in the mouse behavioral despair test
75 Citations1990Margarita L. Dubocovich, E. Mogilnicka +1 more
It is concluded that luzindole may exert antidepressant-like activity in the C3H/HeN mouse by antagonizing the action of endogenous hormone, and the results suggest that endogenous melatonin plays a role during swimming during the behavioral despair test.
PsychopharmacologyAdditive effects of lithium and antidepressants in the forced swimming test: further evidence for involvement of the serotoninergic system
74 Citations1994Melissa Nixon, Martine Hascoët +2 more
The hypothesis that the potentiation by lithium of ADS is via direct 5HT mechanisms, indirect via a NA/5HT link, and/or by second messenger systems is supported.
Brain ResearchSerotonin levels in hippocampus: striking variations associated with mouse strain and treatment
68 Citations1973Richard E. Wimer, Norman Reid +1 more
PsychopharmacologyRole of genotype and dopamine receptors in behaviour of inbred mice in a forced swimming test
63 Citations1991Ella M. Nikulina, Julia A. Skrinskaya +1 more
A different role for D1 and D2 dopamine receptors in the regulation of swimming in the mouse is suggested, with the effects being genotype dependent.
European NeuropsychopharmacologyDifferential effects of clonidine, lithium and quinine in the forced swimming test in mice for antidepressants: possible roles of serotoninergic systems
62 Citations1996Michel Bourin, Martine Hascoët +3 more
The results of the present study are in favour of the potentiation of AD activity by clonidine via 5-HT2 receptors, lithium through 5- HT1A receptors, and quinine through5-HT3 receptors, which is the most important in the actions of individual ADs.
PsychopharmacologyDose-dependent influence of buspirone on the activities of selective serotonin reuptake inhibitors in the mouse forced swimming test
56 Citations1998John P. Redrobe, Michel Bourin
Low dose buspirone enhanced the activity of subactive doses of SSRIs in the mouse forced swimming test, probably via an action at 5-HT1A receptors and attenuated all SSRI-induced anti-immobility effects.
Journal of Pharmacology and Experimental TherapeuticsCommon genetic determinants of the ataxic and hypothermic effects of ethanol in BXD/Ty recombinant inbred mice: genetic correlations and quantitative trait loci.
56 Citations1996John C. Crabbe, Tamara J. Phillips +3 more
The analyses presented suggest modest commonality of genetic influence on tolerance to some measures of ataxia and hypothermia, and they strongly support previous data indicating that sensitivity and tolerance to specific effects of ethanol share common genetic determinants.
Journal of PsychopharmacologyInfluence of anxiolytic drugs on the effects of specific serotonin reuptake inhibitors in the forced swimming test in mice
50 Citations1997Mario A. Da-Rocha, Alain Puech +1 more
The results suggest that pharmacodynamic interactions exist between various anxiolytics and SSRIs, which probably involve both serotonergic and GABAergic processes, and indicate that the influence of anxIOlytics on the action of SSRI antidepressants is variable.
PsychobiologyReactions to spatial and nonspatial change in two inbred strains of mice: Further evidence supporting the hippocampal dysfunction hypothesis in the DBA/2 strain
45 Citations1995Martine Ammassari‐Teule, Alessandro Tozzi +3 more
The results support the hypothesis that DBA mice represent a genetic model of hippocampal dysfunction and suggest that mice from this strain reproduce more specifically the dorsal hippocampal syndrome.
Behavior GeneticsDifferences in one-way active avoidance learning in mice of three inbred strains
43 Citations1992Susan B. Weinberger, George F. Koob +1 more
DBA/2J mice showed a significantly greater task retention from one testing day to the next than did C57BL/6J or C3H/HeJ mice, and were found to differ in their abilities to learn and retain the response.
Journal of Pharmacy and PharmacologyMesulergine antagonism towards the fluoxetine anti-immobility effect in the forced swimming test in mice
42 Citations1993Raffaele Cesana, Angelo Ceci +2 more
The results suggest that fluoxetine reduces immobility time in mice forced to swim, by acting indirectly through a mesulergine‐sensitive site, probably the 5‐HT1C receptor.
Journal of Pharmacology and Experimental TherapeuticsMapping the genes for haloperidol-induced catalepsy.
40 Citations1996Stephen Kanes, Katherine M. Dains +7 more
The data illustrate that either near or part of Drd2 is a QTL which has significant effects on both haloperidol response and D2 dopamine receptor binding, however, the data also illustrate that most of the genetic variance in either haloperIDol response or D2 serotonin receptor binding is not associated with Drd 2.
PsychopharmacologyThe effects of cocaine on operant responding for food in several strains of mice
33 Citations1997Charles J. Heyser, Jeffrey S. McDonald +3 more
It is suggested that operant performance and the effect of cocaine on this behavior is differentially influenced by genetic make-up.
Life SciencesBehavioral effects of (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, (DOI) in the elevated plus-maze test
31 Citations1995Emmanuel S. Onaivi, Cassandra Bishop-Robinson +2 more
Physiology & BehaviorEffect of exposure to novelty on brain monoamines in C57BL/6 and DBA/2 mice
28 Citations1996Byron C. Jones, Xu Hou +1 more
The data suggest that genetically based neurophysiological and neurochemical differences exist in dopaminergic and serotonergic systems in mice, and that the DA systems in NA may be more sensitive to novelty than other DA systems.
European Journal of PharmacologyNaloxone potentiates the effects of subeffective doses of anxiolytic agents in mice
27 Citations1997Catherine Belzung, Anders Ågmo
The ability of the opioid receptor antagonist naloxone to potentiate the effects of subeffective doses of chlordiazepoxide, diazepam and buspirone was evaluated in Swiss mice tested in an elevated plus maze and data suggest that nAloxone is able to potentiates the effect of anti-anxiety agents.
Journal of Pharmacology and Experimental TherapeuticsOpioid Receptor Selectivity of Heroin Given Intracerebroventricularly Differs in Six Strains of Inbred Mice
27 Citations1999Jodie J. Rady, Gregory I. Elmer +1 more
The results indicate that the opioid receptor selectivity of heroin is genotype-dependent and genetically determined molecular and neurochemical substrate mediating the different opioid receptors selectivities of heroin can be studied further.
Behavior GeneticsGenotypic Differences Between C57BL/6 and A Inbred Mice in Anxiolytic and Sedative Actions of Diazepam
26 Citations1998Kennon M. Garrett, Iwona Niekrasz +3 more
Findings indicate that C57BL/6J and A/J mice provide a valuable tool for behavioral genetic studies of the mechanisms underlying the pharmacological actions of benzodiazepines.
PubMedThe difference in stress-induced analgesia in C57BL/6 and DBA/2 mice: a search for biochemical correlates.
20 Citations1989Barbara Przewłocka, J Vetulani +5 more
The above data indicate that C57 and DBA mice differ in the endogenous opioid peptide content, stress-induced alteration and opioid receptor affinity, the effects which might correlate with their different responses to environmental factors and pharmacological agents.
Psychological ResearchGenetic analysis of avoidance learning by means of different psychological testing systems with inbred mice as model organisms
19 Citations1981Werner Buselmaier, Th. Vierling +2 more
The genetic basis of active avoidance learning was investigated with mice as model organisms by means of different test systems such as the Shuttle-Box with light and sound stimulation and the Skinner- box with light stimulation to postulate a monogenic inheritance of Shuttle- box performance with codominant mode.
Behavior GeneticsGenetic analysis of an avoidance-avoidance response inMus domesticus
8 Citations1989Norman D. Henderson
Latency to leave a lighted platform and enter a novel chamber in which other mice had received shock was measured, and inbred strains showed greater litter variance than F1 hybrids, suggesting greater developmental buffering of heterozygotes.