Assessment of Local Brain Activation
Advances in experimental medicine and biologyPublished 1 January 1997
Kersten Villringer, Satoshi Minoshima, Christoph Höck, Hellmuth Obrig, Sibylle Ziegler, Ulrich Dirnagl
Citations141
SJR quartileQ3
SJR score0.37
SNIP0.20
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
In five healthy human subjects, near-infrared spectroscopy (NIRS) and positron emission tomography (PET) examinations were performed simultaneously and a statistically significant correlation between changes in CBF and changes in [total-Hb] was found, confirming the validity of NIRS measurements in human adults.
Abstract
In five healthy human subjects, near-infrared spectroscopy (NIRS) and positron emission tomography (PET) examinations were performed simultaneously. Changes in [oxy-Hb], [deoxy-Hb] and [total-Hb] as measured by NIRS over the left forehead were compared to measurements of cerebral blood flow by PET during rest and during performance of a calculation task and a Stroop task. When a penetration depth of near-infrared light 0.9 cm into the brain cortex was assumed, a statistically significant correlation between changes in CBF and changes in [total-Hb] was found. These data confirm the validity of NIRS measurements in human adults.
Keywords
MedicineEngineering
ScienceNoninvasive, Infrared Monitoring of Cerebral and Myocardial Oxygen Sufficiency and Circulatory Parameters
3,888 Citations1977Frans F. Jöbsis
Observations by infrared transillumination in the exposed heart and in the brain in cephalo without surgical intervention show that oxygen sufficiency for cytochrome a,a3, function, changes in tissue blood volume, and the average hemoglobin-oxyhemoglobin equilibrium can be recorded effectively and in continuous fashion for research and clinical purposes.
Neuroscience LettersNear infrared spectroscopy (NIRS): A new tool to study hemodynamic changes during activation of brain function in human adults
1,107 Citations1993Arno Villringer, J. Planck +3 more
NIRS is a simple bedside technique for the assessment of hemodynamic alterations accompanying brain activation using near infrared spectroscopy and it is demonstrated that these findings are not due to alterations in skin blood flow.
Medical & Biological Engineering & ComputingSystem for long-term measurement of cerebral blood and tissue oxygenation on newborn infants by near infra-red transillumination
1,058 Citations1988M. Cope, David T. Delpy
The design and performance of an instrument that has been developed to apply the technique of near-infra-red spectroscopy to the monitoring of the brain in newborn infants are described.
Proceedings of the National Academy of SciencesComparison of time-resolved and -unresolved measurements of deoxyhemoglobin in brain.
465 Citations1988B. Chance, J.S. Leigh +8 more
Time-resolved spectroscopy afforded a display of the times and distances of arrival of photons emitted by the cat brain in response to a 10-ps input pulse, and deoxyhemoglobin can be quantified in brain tissues.
Neuroscience LettersDetection of dynamic changes in cerebral oxygenation coupled to neuronal function during mental work in man
461 Citations1993Yoko Hoshi, Mamoru Tamura
Monitoring of the oxygenation state of brain hemoglobin during mental work found that subjects finding difficulty in solving a problem were accompanied by significant increases in both oxygenated hemoglobin and total hemoglobin, while subjects making a correct answer without difficulty showed no significant changes in hemoglobin oxygenation.
Journal of Cerebral Blood Flow & MetabolismHuman Visual Cortical Function during Photic Stimulation Monitoring by Means of near-Infrared Spectroscopy
435 Citations1993Toshinori Kato, Atsushi Kamei +2 more
Cerebral blood volume increased on the occipital surface during PS, but NIRS parameters did not change on the frontal surface, suggesting cerebral vascular dilatation with decreased oxygen consumption.
Journal of Applied PhysiologyDynamic multichannel near-infrared optical imaging of human brain activity
350 Citations1993Yoko Hoshi, Mamoru Tamura
Functional brain mapping with an optical imaging technique by using tissue-transparent near-infrared light shows that there were regional variations of the oxygen delivery-oxygen utilization relationship during activation of brain activity.
Journal of Applied PhysiologyQuantification of adult cerebral hemodynamics by near-infrared spectroscopy
220 Citations1994Clare E. Elwell, M. Cope +4 more
The results demonstrate that near-infrared spectroscopy can be used as a noninvasive bedside technique for both qualitative and quantitative evaluation of cerebral hemodynamics and oxygenation in adults.
Journal of neurosurgeryNear-infrared spectroscopic localization of intracranial hematomas
165 Citations1993Shankar P. Gopinath, Claudia S. Robertson +2 more
Near-infrared spectroscopy of the cerebral hemispheres is useful in the initial examination of the head-injured patient, as an adjunct to CT, and in following patients postoperatively in the intensive care unit.
Neuroscience LettersNon-synchronous behavior of neuronal activity, oxidative metabolism and blood supply during mental tasks in man
145 Citations1994Yoko Hoshi, Hirotaka Onoe +6 more
Are mental tasks always associated with increases in r-CBF and/or CMRO2?
Brain ResearchGender- and handedness-related differences of forebrain oxygenation and hemodynamics
50 Citations1993Fumihiko Okada, Yukiko Tokumitsu +2 more
NIR results showed that a large majority of women used both sides of the brain when concentrating on carrying out the MDT, whilst most men, especially left-handers, reacted mainly using the hemisphere which was 'dominant' according to handedness.