Beta-lactamase-negative, methicillin-resistant Staphylococcus aureus in a newborn nursery: report of an outbreak and laboratory investigations
Journal of Hospital InfectionPublished 1 August 1990
Judith Richardson, A.H. Quoraishi, Buadi Francis, R. R. Marples
Citations45
SJR quartileQ1
SJR score1.02
SNIP1.15
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
An outbreak of skin infection caused by a beta-lactamase-negative strain of methicillin-resistant Staphylococcus aureus (MRSA) occurred during a five-week period in a newborn nursery, thought to have been introduced from a different maternity unit by a nasal carrier.
Abstract
An outbreak of skin infection caused by a beta-lactamase-negative strain of methicillin-resistant Staphylococcus aureus (MRSA) occurred during a five-week period in a newborn nursery. Twelve babies, two mothers and two members of staff were involved. One baby had a diagnosis of staphylococcal scalded skin syndrome and two others required treatment with antibiotics. The infecting strain produced exfoliative toxin A. It was thought that it had been introduced from a different maternity unit by a nasal carrier. Laboratory investigations tended to support this hypothesis.
Keywords
Immunology and MicrobiologyMedicine
PubMedPhage typing of staphylococci.
744 Citations1961J. E. Blair, R. E. O. Williams
A detailed account of methods that have been found satisfactory for propagating the phages are given and a standard testing routine by which the stability of the phage preparations can be verified is defined.
Microbiological ReviewsAntimicrobial resistance of Staphylococcus aureus: genetic basis
587 Citations1987B. R. Lyon, Ronald A. Skurray
The evolution of S. aureus Resistance Plasmids and the Multiresistant Chromosome is studied to determine the role of PBPs in Methicillin Resistance.
American journal of diseases of childrenTransmission of Staphylococci Between Newborns
156 Citations1962Edward A. Mortimer
The present studies provided evidence which indicates that the air is not a major route of spread of organisms between infants and suggests that the hands of personnel may play a role in the transport of staphylococci between infants.
British Journal of DermatologyTOXIC EPIDERMAL NECROLYSIS PRODUCED BY AN EXTRACELLULAR PRODUCT OF STAPHYLOCOCCUS AUREUS
90 Citations1971J. P. Arbuthnott, JANET KENT +2 more
A typical phage group 2 staphylococcal isolate from a case of toxic epidermal necrolysis of Ritter's type produces a diffusible macromolecular thermolabile product which rapidly induces epider mal necroelsis in new‐born mice, and the susceptibility to this ne crolytic factor decreases markedly with age.
Journal of Medical MicrobiologyCharacterisation of methicillin-resistant Staphylococcus aureus isolates by restriction endonuclease digestion of chromosomal DNA
77 Citations1988J. Z. Jordens, Lucinda M. C. Hall
Results confirm the discriminatory value of restriction pattern analysis as a typing method and confirm that a single strain of methicillin-resistant S. aureus persists at the London Hospital, although its antibiotic-resistance profile and plasmid carriage are not constant.
Journal of Medical MicrobiologySerological Detection Of Enterotoxin From Food-Poisoning Strains Of Staphylococcus Aureus
67 Citations1971M Simkovicová, Richard J. Gilbert
Cultures of Staphylococcus aureus from 36 food-poisoning incidents in Great Britain during the period 1961–69 were examined for their ability to produce enterotoxins A, B, C and, in some tests, enterotoxin D.
Journal of Medical MicrobiologySupplementary phages for the investigation of strains of methicillin-resistant Staphylococcus aureus
51 Citations1988Judith Richardson, N. CHITTASOBHON +1 more
Nineteen experimental phages derived by mitomycin-C induction from methicillin-resistant strains of Staphylococcus aureus collected world-wide were assessed for their ability to distinguish isolates of a methamphetamine-resistant strain of S. aureUS epidemic in the London area from other British strains, both sensitive and resistant to methingillin.
Journal of Antimicrobial ChemotherapyCarriage of gentamicin-resistant coagulase-negative staphylococci in patients on continuous ambulatory peritoneal dialysis
12 Citations1987J. E. Degener, J. Naidoo +3 more
It was concluded that out-patients on CAPD may persistently harbour their own gentamicin-resistant coagulase-negative staphylococcal strain and that cross-colonization may also occur.
Archives of Pediatrics and Adolescent MedicineThe Role of a Chronic Carrier in an Epidemic of Staphylococcal Disease in a Newborn Nursery
9 Citations1958Richard T. Smith
The epidemiological studies made possible by bacteriophage typing of this group of micro-organisms have demonstrated that the agent is usually acquired by the infant in the hospital environment, from nursing personnel, from other infants, or possibly from various fomites and that the carrier state may persist long after the infant's discharge from the nursery.