FH proteins as cytoskeletal organizers
Trends in Cell BiologyPublished 1 March 1998
Steven A. Wasserman
Citations192
SJR quartileQ1
SJR score5.46
SNIP2.93
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TL;DR
The structure and function of members of the FH protein family are discussed and the evidence that they interact specifically with Rho GTPases and profilin to organize the actin-based cytoskeleton is examined.
Abstract
Regulation of cell shape is a poorly understood yet central issue in cell biology. Recent experiments indicate that FH proteins link cellular signalling pathways to changes in cell shape. Members of the FH protein family play essential roles in cytokinesis and in driving alterations in cell polarity. This review discusses the structure and function of these proteins and examines the evidence that they interact specifically with Rho GTPases and profilin to organize the actin-based cytoskeleton.
Keywords
Biochemistry, Genetics and Molecular Biology
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